TargetTransporter(Rattus norvegicus)
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetTransporter(Rattus norvegicus)
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 4.5nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetTransporter(Rattus norvegicus)
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 43nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetTransporter(Rattus norvegicus)
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 79nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 785nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 795nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 964nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 1.14E+3nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 1.54E+3nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 4.87E+3nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetTransporter(Rattus norvegicus)
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetTransporter(Rattus norvegicus)
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat brainstem incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes Of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-WIN 3542875 from DAT in Sprague-Dawley rat brain striatum incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant Nav 1.8 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human Nav1.8 channel expressed in HEK293 cells at -40 mV by patch clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human Nav1.8 channel expressed in human HEK293 cells by patch clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant rat Nav1.8 sodium channel assessed as blockade of TTXR current by patch clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of human Nav1.8 channel expressed in HEK293 cells at -100 mV by patch clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant Nav 1.8 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of Nav1.8 channel in rat dorsal root ganglion neurons assessed as blockade of TTX-R current by patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol Myers Squibb
Curated by ChEMBL
Bristol Myers Squibb
Curated by ChEMBL
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of California-San Diego
Curated by ChEMBL
University Of California-San Diego
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as decrease in ACh-induced channel currents at -60 mV holding potential...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of California-San Diego
Curated by ChEMBL
University Of California-San Diego
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as decrease in ACh-induced channel currents at -60 mV holding potential...More data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 390nMAssay Description:Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of California-San Diego
Curated by ChEMBL
University Of California-San Diego
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as decrease in ACh-induced channel currents at -60 mV holding potential...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of California-San Diego
Curated by ChEMBL
University Of California-San Diego
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as decrease in ACh-induced channel currents at -60 mV holding potential...More data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol Myers Squibb
Curated by ChEMBL
Bristol Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by isotope efflux assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 850nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 960nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 970nMAssay Description:Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Nav1.8 channel in rat dorsal root ganglion neurons assessed as blockade of TTX-R current by patch clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair