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Found 374 with Last Name = 'hirokawa' and Initial = 't'
TargetMuscarinic acetylcholine receptor M1(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M1 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M5 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M4 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M3 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50194208((1S,2R)-trans-2-[2-(4-chlorobenzylamino)ethyl]-1-(...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50374004(CHEMBL271108)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M1 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50374004(CHEMBL271108)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M4 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50318106((1S,2R)-2-[(1R)-1-Ethyl-2-(4-chlorobenzylamino)eth...)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50194203((1R,2R)-cis-2-[2-(4-chlorobenzylamino)ethyl]-1-(1H...)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50374004(CHEMBL271108)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50374004(CHEMBL271108)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M3 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50374004(CHEMBL271108)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M5 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50318103((1R,2S)-2-[(1R)-1-Ethyl-2-(4-chlorobenzylamino)eth...)
Affinity DataKi:  19.8nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  51.1nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50318105((1S,2R)-2-[(1S)-1-Ethyl-2-(4-chlorobenzylamino)eth...)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50318104((1R,2S)-2-[(1S)-1-Ethyl-2-(4-chlorobenzylamino)eth...)
Affinity DataKi:  129nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50453074(CHEMBL4215958)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]NMS from muscarinic receptor in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50453077(CHEMBL4216478)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]NMS from muscarinic receptor in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [3H]NMS from muscarinic receptor in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50453073(CHEMBL4204282)
Affinity DataIC50:  7.10nMAssay Description:Displacement of [3H]NMS from muscarinic receptor in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Biomedicinal Information Research Center (Birc)

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human HDAC1 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50453076(CHEMBL4211510)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]NMS from muscarinic receptor in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50453068(CHEMBL4206276)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]NMS from muscarinic receptor in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50453070(CHEMBL4208614)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]NMS from muscarinic receptor in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome assembly chaperone 3(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50520988(CHEMBL4435319)
Affinity DataIC50:  20nMAssay Description:Inhibition of PAC3 homodimer (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50:  39nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50453072(CHEMBL4207504)
Affinity DataIC50:  123nMAssay Description:Displacement of [3H]NMS from muscarinic receptor in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome assembly chaperone 3(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50316413((S)-2-hydroxy-2-(((S,E)-4-(hydroxy((1R,2R,4aS,8aR)...)
Affinity DataIC50:  200nMAssay Description:Inhibition of PAC3 homodimerization by protein fragment complementation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50226373(1-(4-Amino-phenyl)-3-(3-benzo[1,3]dioxol-5-yl-4-ox...)
Affinity DataIC50:  380nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50226374(1-(4-Amino-phenyl)-3-[3-(4-hydroxy-phenyl)-4-oxo-2...)
Affinity DataIC50:  650nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50226372(1-(3-Benzo[1,3]dioxol-5-yl-4-oxo-2,4-dihydro-inden...)
Affinity DataIC50:  700nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Biomedicinal Information Research Center (Birc)

Curated by ChEMBL
LigandPNGBDBM50379295(CHEMBL2011672)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of human HDAC1 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Biomedicinal Information Research Center (Birc)

Curated by ChEMBL
LigandPNGBDBM50379297(CHEMBL2011674)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibition of human HDAC1 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Biomedicinal Information Research Center (Birc)

Curated by ChEMBL
LigandPNGBDBM50379298(CHEMBL2011675)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of human HDAC1 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Biomedicinal Information Research Center (Birc)

Curated by ChEMBL
LigandPNGBDBM50379296(CHEMBL2011673)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of human HDAC1 after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome assembly chaperone 3(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50520986(CHEMBL4466606)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of PAC3 homodimer (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome assembly chaperone 3(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50520987(CHEMBL4447106)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of PAC3 homodimer (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome assembly chaperone 1/2(Homo sapiens)
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50520988(CHEMBL4435319)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of PAC1/PAC2 heterodimer (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50177117(CHEMBL3814092)
Affinity DataEC50:  180nMAssay Description:Mu2 opioid receptor affinity against the receptor site model site 2 (mu2) by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50177117(CHEMBL3814092)
Affinity DataEC50:  180nMAssay Description:Mu2 opioid receptor affinity against the receptor site model site 2 (mu2) by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50177117(CHEMBL3814092)
Affinity DataEC50:  180nMAssay Description:Mu2 opioid receptor affinity against the receptor site model site 2 (mu2) by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50238929(CHEMBL4067351)
Affinity DataEC50:  260nMAssay Description:Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50238929(CHEMBL4067351)
Affinity DataEC50:  260nMAssay Description:Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50238929(CHEMBL4067351)
Affinity DataEC50:  260nMAssay Description:Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50238929(CHEMBL4067351)
Affinity DataEC50:  257nMAssay Description:Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50238929(CHEMBL4067351)
Affinity DataEC50:  257nMAssay Description:Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50238929(CHEMBL4067351)
Affinity DataEC50:  257nMAssay Description:Agonist activity at mouse GPR34 expressed in HEK293 cells co-transfected with AP-TGFalpha/chimeric Galphaq/i1 assessed as induction of ectodomain she...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50238930(CHEMBL4094801)
Affinity DataEC50:  2.00E+3nMAssay Description:Opioid receptor affinity against Opioid receptor kappa 1 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 34(Mus musculus)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50238930(CHEMBL4094801)
Affinity DataEC50:  2.00E+3nMAssay Description:Opioid receptor affinity against Opioid receptor kappa 1 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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