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Found 1603 with Last Name = 'hof' and Initial = 'f'
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM86211(CAS_52809-07-1 | NSC_40539 | Quisqualate)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50002371(2-aminopentanedioic acidglutamic acid | CHEMBL2763...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50171313((3-Ethyl-2-methyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataKi:  0.870nMAssay Description:In vitro affinity for cloned rat metabotropic glutamate 1 receptors stably expressed on CHO cells determined using [3H]-R214127 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50089896(4-(Amino-carboxy-methyl)-3-methyl-benzoic acid((+)...)
Affinity DataKi:  1.18nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50163606(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-ph...)
Affinity DataKi:  1.35nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50231744(CHEMBL399160 | NPS 2390 | quinoxaline-2-carboxylic...)
Affinity DataKi:  1.36nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123685(4-Bromo-5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50067499((6aR,10aR)-3(1,1-dimethylheptyl)-9-hydroxymethyl)-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030628((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)
Affinity DataKi:  1.65nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM86212(1S, 3R-ACPD | CAS_104766 | NSC_104766)
Affinity DataKi:  1.92nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50266832(1-(2,4-Dichlorophenyl)-4-cyano-5-(4-methoxyphenyl)...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123690(1-(2,4-Dichloro-phenyl)-5-(4-methoxy-phenyl)-4-met...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030629((R,S)-4-Carboxy-3-hydroxyphenylglycine | (S)-4CPG ...)
Affinity DataKi:  4.51nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50267374(1-(2-bromophenyl)-4-cyano-5-(4-methoxyphenyl)-N-(p...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123688(4-Bromo-1-(2,4-dichloro-phenyl)-5-(4-methoxy-pheny...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123693(4-Bromo-1-(2-chloro-phenyl)-5-(4-methoxy-phenyl)-1...)
Affinity DataKi:  6.20nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123689(1-(2,4-Dichloro-phenyl)-5-(4-methoxy-phenyl)-4-met...)
Affinity DataKi:  7nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123691(5-Benzo[1,3]dioxol-5-yl-1-(2,4-dichloro-phenyl)-4-...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123684(1-(2-Chloro-phenyl)-5-(4-methoxy-phenyl)-4-methyl-...)
Affinity DataKi:  8nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123692(5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-pyr...)
Affinity DataKi:  9nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Mus musculus (mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442299(CHEMBL2442750)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-prostaglandin D2 from mouse CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50266833(1-(2,4-Dichlorophenyl)-4-cyano-5-(4-(fluoromethoxy...)
Affinity DataKi:  10.3nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50267373(4-cyano-1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50212323((3aS,6aS)-5-methylene-6a-(naphthalen-2-ylmethyl)-h...)
Affinity DataKi:  11.2nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50267375(1-(2-Chloro-4-fluorophenyl)-4-cyano-5-(4-methoxyph...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50266809(1-(2,4-Dichlorophenyl)-4-cyano-5-(4-bromophenyl)-N...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123683(1-(2-Chloro-phenyl)-4-fluoro-5-(4-methoxy-phenyl)-...)
Affinity DataKi:  18.2nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50266864(5-(4-chlorophenyl)-4-cyano-1-(2,4-dichlorophenyl)-...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM17785(2-aminoquinazoline, 3 | 4-(2-amino-6-phenoxy-3,4-d...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296848(2-(1-(3,4-difluorophenylsulfonyl)-2-methyl-1H-pyrr...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50266807(1-(2-Bromo-4-fluorophenyl)-4-cyano-5-(4-methoxyphe...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50266808(1-(2,4-Dichlorophenyl)-4-cyano-5-(4-iodophenyl)-N-...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442299(CHEMBL2442750)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123687(1-(2-Fluoro-phenyl)-5-(4-methoxy-phenyl)-4-methyl-...)
Affinity DataKi:  37.8nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030630((RS)-1-aminoindan-1,5-dicarboxylic acid | 1-Amino-...)
Affinity DataKi:  98.3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50296851(2-(1-(4-chlorophenylsulfonyl)-2-methyl-1H-pyrrolo[...)
Affinity DataKi:  103nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50123694(1-(2,4-Dichloro-phenyl)-5-(4-hydroxy-phenyl)-4-met...)
Affinity DataKi:  104nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442309(CHEMBL2442743)
Affinity DataKi:  109nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50266830(1-(2,4-Dichlorophenyl)-4-cyano-5-(4-iodophenyl)-N-...)
Affinity DataKi:  131nMAssay Description:Displacement of [3H]CP55940 form human recombinant CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442310(CHEMBL2442742)
Affinity DataKi:  145nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442300(CHEMBL2442751)
Affinity DataKi:  147nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442302(CHEMBL2442736)
Affinity DataKi:  149nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM17784(2-aminoquinazoline, 2 | 3-[(2-amino-6-phenoxy-3,4-...)
Affinity DataKi:  158nM ΔG°:  -38.4kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Johnson and Johnson Pharmaceutical Research and Development, Beerse

Curated by PDSP Ki Database
LigandPNGBDBM50030627((+-)-MCPG | (R,S)-alpha-Methyl-4-carboxyphenylglyc...)
Affinity DataKi:  165nMMore data for this Ligand-Target Pair
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442303(CHEMBL2442752)
Affinity DataKi:  208nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50442301(CHEMBL2442748)
Affinity DataKi:  249nMAssay Description:Displacement of [3H]-prostaglandin D2 from human CRTh2 receptor expressed in CHO cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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