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Found 33 with Last Name = 'houston' and Initial = 'jg'
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50400098(CHEMBL2178422)
Affinity DataKi:  0.0270nMAssay Description:Displacement of [125I]-CGRP from CGRP receptor in human SK-N-MC cells after 2 hrs by gamma scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50400099(CHEMBL2178420)
Affinity DataKi:  0.0660nMAssay Description:Displacement of [125I]-CGRP from CGRP receptor in human SK-N-MC cells after 2 hrs by gamma scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50400102(CHEMBL2178424)
Affinity DataKi:  0.0810nMAssay Description:Displacement of [125I]-CGRP from CGRP receptor in human SK-N-MC cells after 2 hrs by gamma scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50400100(CHEMBL2178421)
Affinity DataKi:  0.670nMAssay Description:Displacement of [125I]-CGRP from CGRP receptor in human SK-N-MC cells after 2 hrs by gamma scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50400101(CHEMBL2178423)
Affinity DataKi:  4.30nMAssay Description:Displacement of [125I]-CGRP from CGRP receptor in human SK-N-MC cells after 2 hrs by gamma scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037287((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  3nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037287((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  3nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037286((1S,3S,4S,5R,6R,7R)-1-((4R,5S)-4-Acetoxy-5-methyl-...)
Affinity DataIC50:  5nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037285((1S,3S,4S,5R,6R,7R)-6-((E)-(4S,6S)-4,6-Dimethyl-oc...)
Affinity DataIC50:  5nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037287((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  7nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037287((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  7nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037279((1S,3S,4S,5R,6R,7R)-6-((4R,6S)-4,6-Dimethyl-octano...)
Affinity DataIC50:  8nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037279((1S,3S,4S,5R,6R,7R)-6-((4R,6S)-4,6-Dimethyl-octano...)
Affinity DataIC50:  9nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037286((1S,3S,4S,5R,6R,7R)-1-((4R,5S)-4-Acetoxy-5-methyl-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037289((1S,3S,4S,5R,6R,7R)-1-((4R,5S)-4-Acetoxy-5-methyl-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037291((1S,3S,4S,5R,6R,7R)-6-((4R,6S)-4,6-Dimethyl-octano...)
Affinity DataIC50:  13nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037291((1S,3S,4S,5R,6R,7R)-6-((4R,6S)-4,6-Dimethyl-octano...)
Affinity DataIC50:  14nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037290((1S,3S,4S,5R,6R,7R)-1-((E)-(4R,5S)-4-Acetoxy-3,5-d...)
Affinity DataIC50:  22nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037280((1S,3S,4S,5R,6R,7R)-1-((4R,5S)-4-Acetoxy-5-methyl-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037288((1S,3S,4S,5R,6R,7R)-6-((E)-(4S,6S)-4,6-Dimethyl-oc...)
Affinity DataIC50:  32nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037282((1S,3S,4S,5R,6R,7R)-6-((E)-(4S,6S)-4,6-Dimethyl-oc...)
Affinity DataIC50:  65nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037284((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  143nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037281((1S,3S,4S,5R,6R,7R)-1-((R)-3,5-Dimethyl-6-phenyl-h...)
Affinity DataIC50:  200nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037283((1S,3S,4S,5R,6R,7R)-1-((E)-(S)-3,5-Dimethyl-6-phen...)
Affinity DataIC50:  200nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037284((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  200nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037283((1S,3S,4S,5R,6R,7R)-1-((E)-(S)-3,5-Dimethyl-6-phen...)
Affinity DataIC50:  208nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037292((1S,3S,4S,5R,6R,7R)-4,6,7-Trihydroxy-1-((4R,5S)-4-...)
Affinity DataIC50:  252nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037281((1S,3S,4S,5R,6R,7R)-1-((R)-3,5-Dimethyl-6-phenyl-h...)
Affinity DataIC50:  415nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50400098(CHEMBL2178422)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human recombinant CYP3A4 using 7-benzyloxy-4-trifluoromethylcoumarin as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50400098(CHEMBL2178422)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human recombinant CYP3A4 using benzoylresorufin as substrate after 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283774(4-Cyano-N-(2-piperidin-1-yl-phenyl)-benzamide | CH...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of human recombinant MMP-IMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeuromedin-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283773((E)-1-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperaz...)
Affinity DataIC50:  6.00E+4nMAssay Description:Compound was tested for its ability to displace [3H]-senktide binding to human Tachykinin receptor 3 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50400098(CHEMBL2178422)
Affinity DataEC50:  0.140nMAssay Description:Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 15 mins prior ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed