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Found 102 with Last Name = 'howe' and Initial = 'ay'
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176475(((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydr...)
Affinity DataIC50:  50nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187218((S)-1-(3,4,5-trichloro-2-hydroxyphenylsulfonyl)pyr...)
Affinity DataIC50:  80nMAssay Description:Cytotoxicity against human Huh7 cell line containing HCV genotype 1b repliconMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150374(2-[(2-Bromo-6-methoxy-5-trifluoromethyl-naphthalen...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176486((5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H...)
Affinity DataIC50:  130nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176480((5,8-dichloro-1-propyl-3,4-dihydro-1H-benzo[4,5]th...)
Affinity DataIC50:  140nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176488(((R)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benz...)
Affinity DataIC50:  170nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176479((5-bromo-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...)
Affinity DataIC50:  190nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187221((4S)-3-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1,...)
Affinity DataIC50:  240nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187232((S)-1-(3-bromo-5-chloro-2-hydroxyphenylsulfonyl)py...)
Affinity DataIC50:  260nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176476((5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,...)
Affinity DataIC50:  320nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150385(2-[(6-Methoxy-5-trifluoromethyl-naphthalene-1-carb...)
Affinity DataIC50:  490nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187217(2,4-dichloro-6-{[(2S)-2-(2H-tetrazol-5-yl)pyrrolid...)
Affinity DataIC50:  560nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157734(2-(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyr...)
Affinity DataIC50:  570nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150365(2-[(5-Bromo-6-methoxy-naphthalene-1-carbonyl)-amin...)
Affinity DataIC50:  590nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176483((1-butyl-5,8-dichloro-3,4-dihydro-1H-benzo[4,5]thi...)
Affinity DataIC50:  750nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187228((S)-1-(3,5-dichloro-2-hydroxyphenylsulfonyl)pyrrol...)
Affinity DataIC50:  770nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150370(CHEMBL183364 | [Carboxymethyl-(6-methoxy-5-trifluo...)
Affinity DataIC50:  900nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150368(2-[(2-Bromo-6-methoxy-5-trifluoromethyl-naphthalen...)
Affinity DataIC50:  910nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182775(3-allyl-5,8-dichloro-1,2,3,4-tetrahydrocyclopenta[...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150375(2-[(5-Bromo-6-methoxy-naphthalene-1-carbonyl)-amin...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150382(2-[(6-Methoxy-5-trifluoromethyl-naphthalene-1-carb...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187233((2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pyr...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150369(CHEMBL83984 | [(2-Bromo-6-methoxy-5-trifluoromethy...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150379(2-[(2-Fluoro-6-methoxy-5-trifluoromethyl-naphthale...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176489((5,8-dichloro-1-propyl-3,4-dihydro-1H-benzo[4,5]fu...)
Affinity DataIC50:  1.49E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182777(3-butyl-8-cyano-7-fluoro-5-methyl-1,2,3,4-tetrahyd...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187224((4R)-3-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1,...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182768(8-cyano-7-fluoro-5-methyl-3-propyl-1,2,3,4-tetrahy...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182788(3-butyl-5,8-dichloro-1,2,3,4-tetrahydrocyclopenta[...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176481((5,8-dichloro-1-ethyl-3,4-dihydro-1H-benzo[4,5]thi...)
Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182786(2-(5-cyano-8-fluoro-1-propyl-2,3,4,9-tetrahydro-1H...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187230((2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pip...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150378(CHEMBL316179 | [(2-Bromo-6-methoxy-5-trifluorometh...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182765(2-(5-cyano-8-methyl-1-propyl-2,3,4,9-tetrahydro-1H...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187222((S)-1-(3-chloro-5-fluoro-2-hydroxyphenylsulfonyl)p...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150381(2-[(2-Fluoro-6-methoxy-5-trifluoromethyl-naphthale...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182769(2-(5,8-dicyano-1-propyl-2,3,4,9-tetrahydro-1H-carb...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176485(((S)-5-cyano-8-methyl-1-propyl-3,4-dihydro-1H-benz...)
Affinity DataIC50:  2.85E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150377(CHEMBL182728 | [(2-Bromo-6-methoxy-5-trifluorometh...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187225((S)-1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyr...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150366(CHEMBL82516 | [(2-Bromo-6-methoxy-5-trifluoromethy...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182785(5,8-dichloro-1-propyl-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150376(CHEMBL183498 | [Allyloxycarbonyl-(2-bromo-6-methox...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50176482((1-butyl-5,8-dichloro-3,4-dihydro-1H-benzo[4,5]fur...)
Affinity DataIC50:  4.46E+3nMAssay Description:Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182789(3-butyl-8-cyano-5-methyl-1,2,3,4-tetrahydrocyclope...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50182783(8-cyano-5-methyl-3-propyl-1,2,3,4-tetrahydrocyclop...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of HCV 1b BK NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187229(2,4-dichloro-6-(pyrrolidin-1-ylsulfonyl)phenol | C...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150373(CHEMBL183575 | [(2-Bromo-6-methoxy-5-trifluorometh...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150371(CHEMBL84384 | [(2-Chloro-6-methoxy-5-trifluorometh...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150362(CHEMBL310098 | [(2-Chloro-6-methoxy-5-trifluoromet...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibitory concentration against HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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