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Found 91 with Last Name = 'huang' and Initial = 'hj'
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11234((2S)-N-(2-chloro-4-nitrophenyl)-2-{[4-(dimethylami...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/mole IC50:  60nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11261(dipeptidomimetic unsaturated ester 18c | ethyl (2E...)
Affinity DataKi:  520nM ΔG°:  -35.9kJ/mole IC50:  1.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11240(Anilide Inhibitor 4k | N-[(benzyloxy)carbonyl]-L-v...)
Affinity DataKi:  1.51E+3nM ΔG°:  -33.2kJ/mole IC50:  6.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11239((2S)-N-[(1S)-1-{[(1S,2S)-1-{[(1S)-1-[(2-chloro-4-n...)
Affinity DataKi:  1.61E+3nM ΔG°:  -33.1kJ/mole IC50:  5.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11236((2S)-N-[(1S)-1-[(2-chloro-4-nitrophenyl)carbamoyl]...)
Affinity DataKi:  2.29E+3nM ΔG°:  -32.2kJ/mole IC50:  5.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11260(dipeptidomimetic unsaturated ester 18b | ethyl (2E...)
Affinity DataKi:  2.48E+3nM ΔG°:  -32.0kJ/mole IC50:  5.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11237((2S)-N-[(1S)-1-{[(1S)-1-[(2-chloro-4-nitrophenyl)c...)
Affinity DataKi:  2.90E+3nM ΔG°:  -31.6kJ/mole IC50:  7.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11263(dipeptidomimetic unsaturated ester 18e | ethyl (2E...)
Affinity DataKi:  3.05E+3nM ΔG°:  -31.5kJ/mole IC50:  7.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11241((2S)-N,N'-bis[(1S)-1-[(2-chloro-4-nitrophenyl)carb...)
Affinity DataKi:  3.10E+3nM ΔG°:  -31.4kJ/mole IC50:  4.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11238((2S)-N-[(1S)-1-{[(1S)-1-[(2-chloro-4-nitrophenyl)c...)
Affinity DataKi:  4.30E+3nM ΔG°:  -30.6kJ/mole IC50:  5.00E+3nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11259(dipeptidomimetic unsaturated ester 18a | ethyl (2E...)
Affinity DataKi:  6.44E+3nM ΔG°:  -29.6kJ/mole IC50:  1.00E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
National Taiwan University

LigandPNGBDBM11262(dipeptidomimetic unsaturated ester 18d | ethyl (2E...)
Affinity DataKi:  9.05E+3nM ΔG°:  -28.8kJ/mole IC50:  1.00E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324264((Z)-3-(4-Oxo-2-{[2-oxo-5-(pyrrolidin-1-ylsulfonyl)...)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324267((Z)-3-(2-{[5-(Indolin-1-ylsulfonyl)-2-oxoindolin-3...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324269((Z)-3-(4-Oxo-2-{[2-oxo-5-(phenylsulfonamido)indoli...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324265((Z)-3-(4-Oxo-2-{[2-oxo-5-(piperidin-1-ylsulfonyl)i...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324263((Z)-3-(2-{[5-(N,N-Dimethylsulfamoyl)-2-oxoindolin-...)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324266((Z)-3-(2-{[5-(Morpholinosulfonyl)-2-oxoindolin-3-y...)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324262((Z)-3-(2-{[5-(N-Methylsulfamoyl)-2-oxoindolin-3-yl...)
Affinity DataIC50:  31nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324268((Z)-3-(2-{[5-(Ethylsulfonamido)-2-oxoindolin-3-yli...)
Affinity DataIC50:  34nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324258((Z)-3-(2-{[5-(Allylsulfonyl)-2-oxoindolin-3-yliden...)
Affinity DataIC50:  39nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324257((Z)-3-(2-{[5-(Ethylsulfonyl)-2-oxoindolin-3-yliden...)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324261((Z)-3-{4-Oxo-2-[(2-oxo-5-sulfamoylindolin-3-yliden...)
Affinity DataIC50:  61nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324270((Z)-3-(4-Oxo-2-{[2-oxo-5-(phenylmethylsulfonamido)...)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324271((Z)-Ethyl 3-(4-Oxo-2-{[2-oxo-5-(phenylsulfonamido)...)
Affinity DataIC50:  84nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324274((Z)-N-Methyl-3-(4-oxo-2-{[2-oxo-5-(phenylsulfonami...)
Affinity DataIC50:  117nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324269((Z)-3-(4-Oxo-2-{[2-oxo-5-(phenylsulfonamido)indoli...)
Affinity DataIC50:  156nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324284((Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]...)
Affinity DataIC50:  178nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324283((Z)-3-{4-Oxo-2-[(2-oxoindolin-3-ylidene)methyl]-4,...)
Affinity DataIC50:  208nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324251((Z)-3-{2-[(5-Bromo-2-oxoindolin-3-ylidene)methyl]-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324271((Z)-Ethyl 3-(4-Oxo-2-{[2-oxo-5-(phenylsulfonamido)...)
Affinity DataIC50:  214nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324272((Z)-N-[2-Oxo-3-({4-oxo-3-[3-oxo-3-(pyrrolidin-1-yl...)
Affinity DataIC50:  218nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324277((Z)-N-[3-({3-[3-(Dimethylamino)propyl]-4-oxo-4,5,6...)
Affinity DataIC50:  235nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324255((Z)-3-{2-[(5-Acetamido-2-oxoindolin-3-ylidene)meth...)
Affinity DataIC50:  252nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324259((Z)-3-(2-{[5-(Benzylsulfonyl)-2-oxoindolin-3-ylide...)
Affinity DataIC50:  271nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324273((Z)-N-(3-{[3-(3-Morpholino-3-oxopropyl)-4-oxo-4,5,...)
Affinity DataIC50:  281nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324267((Z)-3-(2-{[5-(Indolin-1-ylsulfonyl)-2-oxoindolin-3...)
Affinity DataIC50:  292nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324276((Z)-N-[2-Oxo-3-({4-oxo-3-[3-(pyrrolidin-1-yl)propy...)
Affinity DataIC50:  310nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324279((Z)-3-({3-[3-(Dimethylamino)propyl]-4-oxo-4,5,6,7-...)
Affinity DataIC50:  312nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324274((Z)-N-Methyl-3-(4-oxo-2-{[2-oxo-5-(phenylsulfonami...)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324278((Z)-N-[3-({3-[3-(Diethylamino)propyl]-4-oxo-4,5,6,...)
Affinity DataIC50:  356nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324253((Z)-3-(2-{[5-(4-Hydroxy-3-methoxyphenyl)-2-oxoindo...)
Affinity DataIC50:  357nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324250((Z)-3-{4-Acetyl-2-[(5-fluoro-2-oxoindolin-3-yliden...)
Affinity DataIC50:  362nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324270((Z)-3-(4-Oxo-2-{[2-oxo-5-(phenylmethylsulfonamido)...)
Affinity DataIC50:  402nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324264((Z)-3-(4-Oxo-2-{[2-oxo-5-(pyrrolidin-1-ylsulfonyl)...)
Affinity DataIC50:  441nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324260((Z)-3-(2-{[5-(4-Fluorobenzylsulfonyl)-2-oxoindolin...)
Affinity DataIC50:  443nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324285((Z)-3-{2-[(5-Fluoro-2-oxoindolin-3-ylidene)methyl]...)
Affinity DataIC50:  456nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324265((Z)-3-(4-Oxo-2-{[2-oxo-5-(piperidin-1-ylsulfonyl)i...)
Affinity DataIC50:  495nMAssay Description:Inhibition of recombinant aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324254((Z)-3-(2-{[5-(3,4-Dimethoxyphenyl)-2-oxoindolin-3-...)
Affinity DataIC50:  560nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50324275((Z)-5-(Indolin-1-ylsulfonyl)-3-{[3-(3-morpholino-3...)
Affinity DataIC50:  563nMAssay Description:Inhibition of recombinant aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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