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Found 411 with Last Name = 'hwang' and Initial = 'sm'
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098576(5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ...)
Affinity DataKi:  0.00480nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  0.160nMAssay Description:Apparent inhibitory constant against human cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50084650(CHEMBL177914 | {(S)-1-[(S)-1-Formyl-2-(4-hydroxy-p...)
Affinity DataKi:  0.260nMAssay Description:Apparent inhibitory constant against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002402(CHEMBL194643)
Affinity DataKi:  0.430nMAssay Description:Apparent inhibitory constant against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50084650(CHEMBL177914 | {(S)-1-[(S)-1-Formyl-2-(4-hydroxy-p...)
Affinity DataKi:  0.470nMAssay Description:Apparent inhibitory constant against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098576(5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ...)
Affinity DataKi:  0.490nMAssay Description:Inhibitory activity of the compound against Human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002399(CHEMBL197958)
Affinity DataKi:  0.560nMAssay Description:Apparent inhibitory constant against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002374(CHEMBL194861)
Affinity DataKi:  0.570nMAssay Description:Apparent inhibitory constant against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50084650(CHEMBL177914 | {(S)-1-[(S)-1-Formyl-2-(4-hydroxy-p...)
Affinity DataKi:  0.740nMAssay Description:Apparent inhibitory constant against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002399(CHEMBL197958)
Affinity DataKi:  0.870nMAssay Description:Apparent inhibitory constant against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002366(CHEMBL433985)
Affinity DataKi:  0.890nMAssay Description:Apparent inhibitory constant against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083761(CHEMBL87429 | [3-Oxo-8-[3-(pyridin-2-ylamino)-prop...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288109(CHEMBL82123 | {2-Benzyl-7-[methyl-(2-piperidin-4-y...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083763(CHEMBL86992 | [(S)-8-[2-(6-Methylamino-pyridin-2-y...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288120(CHEMBL313768 | {2-Cyclohexyl-7-[methyl-(2-piperidi...)
Affinity DataKi:  1.30nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083764(CHEMBL421533 | [3-Oxo-8-[3-(pyridin-2-ylamino)-pro...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078714(CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for non-peptide Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002400(CHEMBL382286)
Affinity DataKi:  1.40nMAssay Description:Apparent inhibitory constant against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288118(CHEMBL312122 | {2-Methyl-7-[methyl-(2-piperidin-4-...)
Affinity DataKi:  1.5nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288119(CHEMBL84073 | {2-Butyl-7-[methyl-(2-piperidin-4-yl...)
Affinity DataKi:  1.5nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50054826(CHEMBL144474 | [7-([4,4']Bipiperidinyl-1-carbonyl)...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078697(CHEMBL54138 | {(S)-7-[2-(1H-Imidazol-2-ylamino)-et...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards human Vitronectin receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50074035(CHEMBL82980 | {7-[(4-Carbamimidoyl-phenyl)-methyl-...)
Affinity DataKi:  1.5nMAssay Description:Fibrinogen receptor binding affinity was determined by assaying for inhibition of [3H]-1 binding to purified Fibrinogen Receptor isolated from human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288115(CHEMBL82746 | {2-(3-Methyl-butyl)-7-[methyl-(2-pip...)
Affinity DataKi:  1.5nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50074035(CHEMBL82980 | {7-[(4-Carbamimidoyl-phenyl)-methyl-...)
Affinity DataKi:  1.5nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098580(Benzofuran-2-carboxylic acid {3-methyl-1-[2-oxo-3-...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50054827(CHEMBL85094 | SB-208651 | {8-[(4-Carbamimidoyl-phe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of binding to purified integrin alphaIIb-beta3 of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50054827(CHEMBL85094 | SB-208651 | {8-[(4-Carbamimidoyl-phe...)
Affinity DataKi:  1.60nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50054827(CHEMBL85094 | SB-208651 | {8-[(4-Carbamimidoyl-phe...)
Affinity DataKi:  1.60nMAssay Description:Fibrinogen receptor binding affinity was determined by assaying for inhibition of [3H]-1 binding to purified Fibrinogen Receptor isolated from human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072493(CHEMBL108490 | [(S)-7-[(1H-Benzoimidazol-2-ylmethy...)
Affinity DataKi:  1.60nMAssay Description:Affinity for alphaIIb-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288117(CHEMBL83756 | {2-[2-(4-Fluoro-phenyl)-ethyl]-7-[me...)
Affinity DataKi:  1.70nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002367(CHEMBL407633)
Affinity DataKi:  1.70nMAssay Description:Apparent inhibitory constant against human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50074030(CHEMBL356020 | {8-[Methyl-(2-piperidin-4-yl-ethyl)...)
Affinity DataKi:  1.90nMAssay Description:Fibrinogen receptor binding affinity was determined by assaying for inhibition of [3H]-1 binding to purified Fibrinogen Receptor isolated from human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072492(CHEMBL419180 | {(S)-7-[(1H-Benzoimidazol-2-ylmethy...)
Affinity DataKi:  1.90nMAssay Description:Effect against adhesion of HEK 293 cells transfected with human alpha-v beta-3 to vitronectin coated platesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083762(CHEMBL314022 | {2-Methyl-3-oxo-8-[3-(pyridin-2-yla...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288114(CHEMBL312409 | {2-Isopropyl-7-[methyl-(2-piperidin...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)
Affinity DataKi:  2nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288110(CHEMBL84063 | {2-(3,3-Dimethyl-butyl)-7-[methyl-(2...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50074029(CHEMBL153162 | [8-(4-Carbamimidoyl-benzoylamino)-3...)
Affinity DataKi:  2nMAssay Description:Fibrinogen receptor binding affinity was determined by assaying for inhibition of [3H]-1 binding to purified Fibrinogen Receptor isolated from human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098584(CHEMBL31947 | {1-[4-(2-Benzyloxycarbonylamino-4-me...)
Affinity DataKi:  2nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288108(CHEMBL82727 | {2-(2-Cyclohexyl-ethyl)-7-[methyl-(2...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288113(CHEMBL311696 | [7-[Methyl-(2-piperidin-4-yl-ethyl)...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity against human alpha IIb beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50074044(CHEMBL152156 | [(S)-8-(4-Carbamimidoyl-phenylcarba...)
Affinity DataKi:  2nMAssay Description:Fibrinogen receptor binding affinity was determined by assaying for inhibition of [3H]-1 binding to purified Fibrinogen Receptor isolated from human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)
Affinity DataKi:  2nMAssay Description:Affinity for vitronectin receptor, integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)
Affinity DataKi:  2nMAssay Description:Inhibition of HEK 293 cell adhesion to vitronectin by alpha V beta 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078710(CHEMBL298782 | {(S)-7-[2-(6-Amino-pyridin-2-ylamin...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards human Vitronectin receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)
Affinity DataKi:  2nMAssay Description:Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)
Affinity DataKi:  2nMAssay Description:Antagonistic activity for human vitronectin receptor (alphaV-beta3) from plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072468(CHEMBL108685 | {(S)-4-Methyl-7-[methyl-(7-methyl-1...)
Affinity DataKi:  2nMAssay Description:Effect against adhesion of HEK 293 cells transfected with human alpha-v beta-3 to vitronectin coated platesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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