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Found 652 with Last Name = 'inoue' and Initial = 's'
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  0.200nMAssay Description:Activity against Matrix metalloproteinase-9 (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063912((R)-N*4*-Hydroxy-N*1*-((S)-methylcarbamoyl-phenyl-...)
Affinity DataIC50:  0.200nMAssay Description:Activity against Matrix metalloproteinase-9 (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063915((2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)...)
Affinity DataIC50:  0.300nMAssay Description:Activity against Matrix metalloproteinase-9 (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063915((2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)...)
Affinity DataIC50:  0.300nMAssay Description:Activity against Matrix metalloproteinase-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063915((2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)...)
Affinity DataIC50:  0.300nMAssay Description:Activity against Matrix metalloproteinase-2 (MMP-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50238110(CHEMBL4088766)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human CYP11B2 expressed in HEK293A cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  0.400nMAssay Description:Activity against Matrix metalloproteinase-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50287290(CHEMBL34866 | KRH-594 | Potassium; 2-[5-ethyl-3-[2...)
Affinity DataIC50:  0.440nMAssay Description:Compound was tested in vitro for the ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50287294(2-[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylm...)
Affinity DataIC50:  0.440nMAssay Description:Compound was tested in vitro for the ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  0.5nMAssay Description:Activity against Matrix metalloproteinase-9 (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50238110(CHEMBL4088766)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human CYP11B1 expressed in HEK293A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063915((2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)...)
Affinity DataIC50:  0.600nMAssay Description:Activity against Matrix metalloproteinase-3 (MMP-3).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  0.650nMAssay Description:Activity against Matrix metalloproteinase-3 (MMP-3).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571009(CHEMBL4865592)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50287291(CHEMBL35381 | N-[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)-...)
Affinity DataIC50:  0.660nMAssay Description:Compound was tested in vitro for the ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571017(CHEMBL4852684)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434413(CHEMBL2387447)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571010(CHEMBL4848604)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571019(CHEMBL4845957)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434425(CHEMBL2387567)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063921((2R,3S)-N*1*-((S)-Cyclohexyl-methylcarbamoyl-methy...)
Affinity DataIC50:  0.900nMAssay Description:Activity against Matrix metalloproteinase-9 (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434435(CHEMBL2387557)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434429(CHEMBL2387563)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 3(Homo sapiens (Human))
Sumitomo Chemical

Curated by ChEMBL
LigandPNGBDBM50381600(CHEMBL2018254)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant 17-beta-HSD3 expressed in human HeLa cells using androstenedione as substrate preincubated for 30 mins prior substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50:  1nMAssay Description:Activity against Matrix metalloproteinase-2 (MMP-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434412(CHEMBL2387448)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434434(CHEMBL2387558)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50439255(CHEMBL2419040)
Affinity DataIC50:  1nMAssay Description:Inhibition of trypsin-activated human recombinant renin using (Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg) as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50387262(CHEMBL2048702)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434414(CHEMBL2387446)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434424(CHEMBL2387568)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434427(CHEMBL2387565)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434428(CHEMBL2387564)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434423(CHEMBL2387569)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571012(CHEMBL4867696)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434411(CHEMBL2387449)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  1.10nMAssay Description:Activity against Matrix metalloproteinase-2 (MMP-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50439253(CHEMBL2419042)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of trypsin-activated human recombinant renin using (Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg) as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Macaca fascicularis)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434421(CHEMBL2387571)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of renin in cynomolgus monkey plasma after 1 hr by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434426(CHEMBL2387566)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50402219(CHEMBL2204732)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant human renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg as substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM50063910((R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propy...)
Affinity DataIC50:  1.30nMAssay Description:Activity against Matrix metalloproteinase-9 (MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571018(CHEMBL4849679)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50439251(CHEMBL2419045)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of trypsin-activated human recombinant renin using (Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg) as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50402219(CHEMBL2204732)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of trypsin-activated human recombinant renin using (Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg) as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434421(CHEMBL2387571)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434419(CHEMBL2387573)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Macaca fascicularis)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50402219(CHEMBL2204732)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of cynomolgus monkey plasma renin assessed as angiotensin 1 level after 60 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50439249(CHEMBL2419046)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of trypsin-activated human recombinant renin using (Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg) as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50434438(CHEMBL2387554)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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