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Found 284 with Last Name = 'jain' and Initial = 'p'
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKi:  0.900nMAssay Description:Inhibition of PARP2 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
Texas A&M University

Curated by ChEMBL
LigandPNGBDBM50336507(4-pyridinecarbohydrazide(Isoniazid) | CHEMBL64 | D...)
Affinity DataKi:  1nMAssay Description:Inhibition of Mycobacterium tuberculosis dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKi:  1.20nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant full-length PARP1 after 4 mins by [32P]NAD+ incorporation assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataKi:  4nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
R. C. Patel Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataKi:  7nMAssay Description:Inhibition of Escherichia coli H560 DNA gyrase B ATPase activity after 30 mins by ammonium molybdate/malachite green-based phosphate detection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  33nMAssay Description:Inhibition of human recombinant MMP1More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataKi:  43nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50068774(8-HYDROXY-2-METHYL-3-HYDRO-QUINAZOLIN-4-ONE | 8-Hy...)
Affinity DataKi:  48nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM27506(3-AB | 3-aminobenzamide | CHEMBL81977)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  0.00400nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  0.00700nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  0.00800nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM24025((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Affinity DataIC50:  0.0380nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM24025((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50137279(6-Hydroxy-2-(4-nitro-benzenesulfonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  0.0410nMAssay Description:Inhibition of MMP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM24025((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Affinity DataIC50:  0.0620nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50137279(6-Hydroxy-2-(4-nitro-benzenesulfonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  0.0760nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of recombinant human PARP2 using histone as substrate after 1 hr in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50137279(6-Hydroxy-2-(4-nitro-benzenesulfonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of MMP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50148201(1-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-cycl...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50148231(2-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-N-hy...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant MMP2 using (7-amino-4-methyl-coumarin)-Pro-Leu-Gly-Leu-(dinitrophenylamine)-Ala-Arg- NH2 as substrate by fluorimetric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536937(CHEMBL4554200)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of mouse recombinant PARP2 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of PARP1 (unknown origin) by NAD+ based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50106136(2-{[4-(4-Chloro-phenoxy)-benzenesulfonyl]-methyl-a...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50428828(CHEMBL2337131)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM24043((2R)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536939(CHEMBL4569417)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PARP1 (unknown origin) using histone as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50095222(CHEMBL83209 | N-Hydroxy-2-[4-(4-trifluoromethyl-ph...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant human PARP1 using histone as substrate after 1 hr in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536936(CHEMBL4584534)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PARP2 (unknown origin) by biotinylated NAD+-based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Durgamata Institute Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of Aurora A (unknown origin) using kemptide acetate as substrate measured after 30 mins by kinase-glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50095218(CHEMBL310008 | N-Hydroxy-2-[4-(4-trifluoromethoxy-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603975(CHEMBL5201780)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536936(CHEMBL4584534)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human PARP1 using histone as substrate after 1 hr in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50428829(CHEMBL2337130)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human recombinant full-length PARP1 after 4 mins by [32P]NAD+ incorporation assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603974(CHEMBL5201904)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536937(CHEMBL4554200)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human recombinant PARP1 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM12075((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50:  8nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536942(CHEMBL4569989)
Affinity DataIC50:  10nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50603992(CHEMBL5179988)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Haspin kinase domain using histone H3 biotin peptide as substrate preincubated with enzyme for 30 mins followed by substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50536939(CHEMBL4569417)
Affinity DataIC50:  11nMAssay Description:Inhibition of PARP2 (unknown origin) using histone as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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