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Found 118 with Last Name = 'jean-claude' and Initial = 'bj'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188463(4-[(3-chlorophenyl)amino]-6-(methylamino)quinazoli...)
Affinity DataIC50:  4nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50211733(1-{4-[(3-chlorophenyl)amino-6-quinazolinyl}-3-{2-[...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of EGFR tyrosine kinase expressed in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM3535(4-N-(3-bromophenyl)-6-N-methylquinazoline-4,6-diam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50160900(CHEMBL181617 | N*4*-(3-Bromo-phenyl)-N*6*-(2-chlor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGFR (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 8 mins in presence of ATP by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50160900(CHEMBL181617 | N*4*-(3-Bromo-phenyl)-N*6*-(2-chlor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of poly(L-glutamic acid-L-tyrosine) phosphorylation by EGFR tyrosine kinase of A431 carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188464(4-[(3-methylphenyl)amino]-6-(methylamino)quinazoli...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133385(CHEMBL134312 | N-(3-bromophenyl)-6-[(1E)-3,3-dimet...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133370(CHEMBL136491 | N-(3-chlorophenyl)-6-[(1E)-3,3-dime...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50215563(4-(3,3-dimethyltriaz-1-en-1-yl)-N-(4-methyl-3-{[4-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of c-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188456(1-(2-chloroethyl)-3-{[4-(3-bromophenyl)amino]quina...)
Affinity DataIC50:  18nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188461(1-(2-chloroethyl)-3-{[4-(3-chlorophenyl)amino]quin...)
Affinity DataIC50:  22nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133379(6-[(1E)-3,3-dimethyltriaz-1-enyl]-N-(3-methylpheny...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133383(6-[(1E)-3-benzyltriaz-1-enyl]-N-(3-bromophenyl)qui...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50160901(CHEMBL179451 | N*6*-(2-Chloro-ethyl)-N*4*-(3-chlor...)
Affinity DataIC50:  26nMAssay Description:Inhibition of poly(L-glutamic acid-L-tyrosine) phosphorylation by EGFR tyrosine kinase of A431 carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50215565(CHEMBL230065 | N-(4-methyl-3-{[4-(pyridin-3-yl)pyr...)
Affinity DataIC50:  28nMAssay Description:Inhibition of c-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  31nMAssay Description:Inhibition of EGFR (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 8 mins in presence of ATP by colorimetric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50215562(4-[3-(hydroxymethyl)-3-methyltriaz-1-en-1-yl]-N-(4...)
Affinity DataIC50:  33nMAssay Description:Inhibition of c-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  33nMAssay Description:Inhibition of EGFR-mediated poly(L-glutamic acid L-tyrosine) phosphorylationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50211735(1-{4-[(3-chlorophenyl)amino-6-quinazolinyl}-3-(2-N...)
Affinity DataIC50:  37nMAssay Description:Inhibition of EGFR tyrosine kinase expressed in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133380(CHEMBL137534 | N-(3-bromophenyl)-6-{(1E)-3-[2-(dim...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133373(CHEMBL137617 | N-(3-bromophenyl)-6-[(1E)-3-methylt...)
Affinity DataIC50:  39nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Abl tyrosine kinaseMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Mus musculus)
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM3294(4-Anilinoquinazoline deriv. 45 | 4-N-(3-bromopheny...)
Affinity DataIC50:  40nMAssay Description:Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  40nMAssay Description:Inhibition of c-AblMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM3294(4-Anilinoquinazoline deriv. 45 | 4-N-(3-bromopheny...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM3294(4-Anilinoquinazoline deriv. 45 | 4-N-(3-bromopheny...)
Affinity DataIC50:  44nMAssay Description:Inhibition of poly(L-glutamic acid-L-tyrosine) phosphorylation by EGFR tyrosine kinase of A431 carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM3294(4-Anilinoquinazoline deriv. 45 | 4-N-(3-bromopheny...)
Affinity DataIC50:  44nMT: 2°CAssay Description:EGFR kinase assay was perform using Nunc MaxiSorp purchased from Nalge Nunc Interantional.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM3294(4-Anilinoquinazoline deriv. 45 | 4-N-(3-bromopheny...)
Affinity DataIC50:  44nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188468(1-(2-chloroethyl)-1-nitroso-3-{[4-(3-bromophenyl)a...)
Affinity DataIC50:  47nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133376(6-[(1E)-3-[(2-morpholin-4-yl)-ethyl]triaz-1-enyl]-...)
Affinity DataIC50:  64nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188466(1-(2-Chloroethyl)-1-nitroso-3-{[4-(3-chlorophenyl)...)
Affinity DataIC50:  67nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133373(CHEMBL137617 | N-(3-bromophenyl)-6-[(1E)-3-methylt...)
Affinity DataIC50:  70nMAssay Description:Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50211736(1-{4-[(3-chlorophenyl)amino-6-quinazolinyl}-3-{2-[...)
Affinity DataIC50:  71nMAssay Description:Inhibition of EGFR tyrosine kinase expressed in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133374(CHEMBL136674 | N-(3-bromophenyl)-6-[(1E)-3-(2-meth...)
Affinity DataIC50:  71nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188459(3-(2-chloroethyl)-1-methyl-1-{[4-(3-chlorophenyl)a...)
Affinity DataIC50:  81nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133372(CHEMBL133024 | N-(3-chlorophenyl)-6-[(1E)-3-methyl...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50136231(((2E)-3-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM81727(Bis-quinazolinotriazene, 5b)
Affinity DataIC50:  120nMT: 2°CAssay Description:EGFR kinase assay was perform using Nunc MaxiSorp purchased from Nalge Nunc Interantional.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Mus musculus)
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50136228(((2E)-3-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50538724(CHEMBL4646415)
Affinity DataIC50:  145nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (668 to end residues) expressed in baculovirus infected Sf9 insect cells assessed as reduc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM81728(Bis-quinazolinotriazene, 5c)
Affinity DataIC50:  150nMT: 2°CAssay Description:EGFR kinase assay was perform using Nunc MaxiSorp purchased from Nalge Nunc Interantional.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50188462(3-(2-chloroethyl)-1-methyl-1-{[4-(3-bromophenyl)am...)
Affinity DataIC50:  156nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50215557(4-amino-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2...)
Affinity DataIC50:  156nMAssay Description:Inhibition of c-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM3535(4-N-(3-bromophenyl)-6-N-methylquinazoline-4,6-diam...)
Affinity DataIC50:  170nMAssay Description:Inhibition of serum-stimulated proliferation of mouse ERBB2 transfected NIH3T3 cell line after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50301422(CHEMBL572030 | vinyl 3-(4-(3-chlorophenylamino)qui...)
Affinity DataIC50:  180nMAssay Description:Inhibition of EGFR-mediated poly(L-glutamic acid L-tyrosine) phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50215561(3-chloro-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin...)
Affinity DataIC50:  180nMAssay Description:Inhibition of c-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50132707(4-3,3-dimethyltriaz-1-ene-N-[4-methyl-3-(4-pyridin...)
Affinity DataIC50:  195nMAssay Description:Inhibition of Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133382(Anilinoquinazoline, 4c | CHEMBL343352 | N*4*-(3-Ch...)
Affinity DataIC50:  200nMT: 2°CAssay Description:EGFR kinase assay was perform using Nunc MaxiSorp purchased from Nalge Nunc Interantional.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133382(Anilinoquinazoline, 4c | CHEMBL343352 | N*4*-(3-Ch...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGFR tyrosine kinase expressed in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mcgill University Health Center/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50133382(Anilinoquinazoline, 4c | CHEMBL343352 | N*4*-(3-Ch...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGFR tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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