TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at PAR1 in washed human platelets assessed as inhibition of haTRAP-induced platelet aggregation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at PAR1 in washed human platelets assessed as inhibition of haTRAP-induced platelet aggregation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity at PAR1 in washed human platelets assessed as inhibition of haTRAP-induced platelet aggregation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Antagonist activity at PAR1 in washed human platelets assessed as inhibition of haTRAP-induced platelet aggregation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.5nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Antagonist activity at PAR1 in washed human platelets assessed as inhibition of haTRAP-induced platelet aggregation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of FITC-geldanamycin binding to N-terminal domain of recombinant full-length HSP90alpha (unknown origin) after 16 hrs by fluorescence pola...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of fluorescein isothiocyanate labeled geldanamycin binding to N-terminal domain of full length human recombinant Hsp90alpha expressed in E...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Fluor de Lys as substrate incubated with compound for 30 mins by microtiter-plate reading...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Fluor de Lys as substrate incubated with compound for 30 mins by microtiter-plate reading...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute
Curated by ChEMBL
Translational Research Institute
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Yonsei University
Curated by ChEMBL
Yonsei University
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of human FLT D835Y mutant using 10 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of fluorescein isothiocyanate labeled geldanamycin binding to N-terminal domain of full length human recombinant Hsp90alpha expressed in E...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Fluor de Lys as substrate incubated with compound for 30 mins by microtiter-plate reading...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Yonsei University
Curated by ChEMBL
Yonsei University
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of human FLT3 using 10 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Korea Research Institute Of Technology
Curated by ChEMBL
Korea Research Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Yonsei University
Curated by ChEMBL
Yonsei University
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of human FLT3 using 10 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Fluor de Lys as substrate incubated with compound for 30 mins by microtiter-plate reading...More data for this Ligand-Target Pair