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Found 133 with Last Name = 'jurewicz' and Initial = 'aj'
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169013(CHEMBL3805703)
Affinity DataKi:  2.90E+3nMAssay Description:Competitive inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) assessed as formation of G6P by continuou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100036((S)-2-(2,4-Dimethyl-benzoylamino)-3-(4-nitro-pheny...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  5nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using [Ca2+] mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140791(1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...)
Affinity DataIC50:  6nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  7nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand,using [Ca2+] mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169042(CHEMBL3806103)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169033(CHEMBL3806069)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169038(CHEMBL3804841)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100044((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169037(CHEMBL3805205)
Affinity DataIC50:  10nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169026(CHEMBL3805148)
Affinity DataIC50:  16nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100027((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169037(CHEMBL3805205)
Affinity DataIC50:  20nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169032(CHEMBL3805398)
Affinity DataIC50:  20nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(CHEMBL245568 | SB-649701)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100037((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140795(1-(2-Bromo-phenyl)-3-(3-chloro-4-cyano-2-hydroxy-p...)
Affinity DataIC50:  22nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(CHEMBL245568 | SB-649701)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169038(CHEMBL3804841)
Affinity DataIC50:  25nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169031(CHEMBL3805905)
Affinity DataIC50:  25nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169041(CHEMBL3805653)
Affinity DataIC50:  25nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169034(CHEMBL3805734)
Affinity DataIC50:  25nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  25nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using Esonophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140796(1-(2-Bromo-phenyl)-3-(4-cyano-2-hydroxy-phenyl)-ur...)
Affinity DataIC50:  25nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169031(CHEMBL3805905)
Affinity DataIC50:  32nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  32nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using Esonophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  32nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using Esonophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423251(CHEMBL240461)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  35nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using Esonophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  38nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand,using CCR3 binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169039(CHEMBL3806132)
Affinity DataIC50:  40nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423244(CHEMBL397395)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169017(CHEMBL3804930)
Affinity DataIC50:  40nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100041((S)-2-Benzoylamino-3-(4-nitro-phenyl)-propionic ac...)
Affinity DataIC50:  49nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423250(CHEMBL395424)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169034(CHEMBL3805734)
Affinity DataIC50:  50nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169043(CHEMBL3806095)
Affinity DataIC50:  50nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50140789(1-(2-Bromo-phenyl)-3-(4-chloro-3-cyano-2-hydroxy-p...)
Affinity DataIC50:  57nMAssay Description:Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100039((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50:  57nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100025((S)-3-(4-Hydroxy-phenyl)-2-[(naphthalene-1-carbony...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169032(CHEMBL3805398)
Affinity DataIC50:  100nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169026(CHEMBL3805148)
Affinity DataIC50:  100nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(CHEMBL245568 | SB-649701)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in Th2 cells assessed as I309 mediated migration by chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423259(CHEMBL395211)
Affinity DataIC50:  126nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169046(CHEMBL3805459)
Affinity DataIC50:  130nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169040(CHEMBL3804874)
Affinity DataIC50:  130nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169033(CHEMBL3806069)
Affinity DataIC50:  130nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169028(CHEMBL3805598)
Affinity DataIC50:  160nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169023(CHEMBL3805753)
Affinity DataIC50:  160nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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