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Found 1429 with Last Name = 'katz' and Initial = 'jl'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256671(CHEMBL4085431)
Affinity DataKi:  0.0730nMAssay Description:Non-competitive inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using varying levels of tyramine as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50217952((1R,5R,9S)-(-)-9-hydroxy-5-(3-hydroxyphenyl-2-phen...)
Affinity DataKi:  0.265nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454823(CHEMBL3084910)
Affinity DataKi:  0.410nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50156916((1R)-3beta-(4-bromophenyl)tropane-2beta-carboxylic...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]WIN 35428 from DAT in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454830(CHEMBL3084869)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454825(CHEMBL3084878)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454828(CHEMBL3084907)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256672(CHEMBL4078283)
Affinity DataKi:  0.741nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454824(CHEMBL3084909)
Affinity DataKi:  0.850nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Affinity DataKi:  0.890nMAssay Description:Displacement of [3H]citalopram from SERT in rat brain stem by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22199(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50324246((S)-(+)-3-(5-Bromo-1-(4-fluorophenyl)-1,3-dihydroi...)
Affinity DataKi:  0.920nMAssay Description:Displacement of [3H]citalopram from SERT in rat brain stem by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  0.950nMAssay Description:Affinity for rat M1 acetylcholine receptor using [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454829(CHEMBL3084870)
Affinity DataKi:  0.980nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50080448(3-[(3-Chloro-phenyl)-phenyl-methoxy]-8-methyl-8-az...)
Affinity DataKi:  0.980nMAssay Description:Binding affinity for muscarinic m1 receptor was determined in vitro in rat brain using [3H]pirenzepine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50324228(CHEMBL1215695 | rac-3-(5-Bromo-1-(4-fluorophenyl)-...)
Affinity DataKi:  1.04nMAssay Description:Displacement of [3H]citalopram from SERT in rat brain stem by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50453903(CHEMBL3084883)
Affinity DataKi:  1.10nMAssay Description:Affinity for rat M1 acetylcholine receptor using [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454827(AMINOBENZTROPINE)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50324244(3-(1-(4-Fluorophenyl)-5-iodo-1,3-dihydroisobenzofu...)
Affinity DataKi:  1.42nMAssay Description:Displacement of [3H]citalopram from SERT in rat brain stem by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  1.46nMAssay Description:Binding affinity towards serotonin transporter using [3H]citalopram as radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM86702(3-[(4-Chloro-phenyl)-phenyl-methoxy]-8-methyl-8-az...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50265358((S)-1-(4-(3-(bis(4-fluorophenyl)amino)propyl)piper...)
Affinity DataKi:  1.72nMAssay Description:Displacement of [3H]WIN-35428 from DAT in rat striatum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50085072(1-{2-[(3-Fluoro-phenyl)-(4-fluoro-phenyl)-methoxy]...)
Affinity DataKi:  1.77nMAssay Description:Displacement of [3H]WIN-35428 from DAT in rat striatum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196226(CHEMBL214234 | S-(+)-2beta-ethenyl-3alpha-[bis(4-f...)
Affinity DataKi:  1.81nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Affinity DataKi:  1.94nMAssay Description:Displacement of [3H]citalopram from SERT in rat brain stem by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50472995(CHEMBL610897)
Affinity DataKi:  2nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256673(CHEMBL4102551)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50006774((2S,3S)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50453899(CHEMBL3084872)
Affinity DataKi:  2.10nMAssay Description:Affinity for rat M1 acetylcholine receptor using [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-me...)
Affinity DataKi:  2.38nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50454826(CHEMBL3084901)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]pirenzepine binding at muscarinic Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  2.60nMAssay Description:Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50453908(CHEMBL3084881)
Affinity DataKi:  2.70nMAssay Description:Affinity for rat M1 acetylcholine receptor using [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50059486((2R,3S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl...)
Affinity DataKi:  2.94nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50494797(CHEMBL3094188)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]citalopram from Sprague-Dawley rat brain stem SERT site S1 by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50264745((S)-1-(4-(3-(bis(4-fluorophenyl)amino)propyl)piper...)
Affinity DataKi:  3.26nMAssay Description:Displacement of [3H]WIN-35428 from DAT in rat striatum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196225(CHEMBL217295 | S-(+)-2beta-Hydroxymethyl-3alpha-[b...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129590(3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin...)
Affinity DataKi:  3.45nMAssay Description:Displacement of [3H]WIN-35428 from DAT in rat striatum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM86702(3-[(4-Chloro-phenyl)-phenyl-methoxy]-8-methyl-8-az...)
Affinity DataKi:  3.60nMAssay Description:Affinity for rat M1 acetylcholine receptor using [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50453905(CHEMBL3084882)
Affinity DataKi:  3.70nMAssay Description:Affinity for rat M1 acetylcholine receptor using [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196232(CHEMBL384482 | S-(+)-2beta-(2'-(methoxycarbonyl)et...)
Affinity DataKi:  3.74nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50324229(3-(4-Bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzof...)
Affinity DataKi:  3.87nMAssay Description:Displacement of [3H]citalopram from SERT in rat brain stem by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  3.96nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM21130(N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]U-69,593 from kappa opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50006784(3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Affinity DataKi:  4nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50156916((1R)-3beta-(4-bromophenyl)tropane-2beta-carboxylic...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]citaloporam from SERT in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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