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Found 274 with Last Name = 'keith' and Initial = 'd'
TargetBifunctional glutamate/proline--tRNA ligase(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097096(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)
Affinity DataKi:  5.10nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional glutamate/proline--tRNA ligase(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097096(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)
Affinity DataKi:  15nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265453((S)-2-(3-((S)-1-Carboxy-5-(3-(4-bromophenyl)ureido...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265381((S)-2-(3-((S)-1-Carboxy-5-(4-chlorobenzylamino)pen...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140706(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against human phenylalanyl-tRNA synthetase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265471((S)-2-(3-((S)-1-Carboxy-5-(3-(4-fluorophenyl)ureid...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265454((S)-2-(3-((S)-1-Carboxy-5-(3-(4-chlorophenyl)ureid...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140706(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097096(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)
Affinity DataIC50:  5nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265474((S)-2-(3-((S)-1-Carboxy-5-(4-iodophenylsulfonamido...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265783((S)-2-(3-((S)-1-Carboxy-5-(3-(4-iodophenyl)ureido)...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265472((S)-2-(3-((S)-1-Carboxy-5-(3-phenylureido)pentyl)u...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50143330((S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265473((9S,13S)-1-(3-iodophenyl)-3,11-dioxo-2,4,10,12-tet...)
Affinity DataIC50:  18nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097082(2-(4-Bromo-phenyl)-6-iodo-quinoline-4-carboxylic a...)
Affinity DataIC50:  19nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097095(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)
Affinity DataIC50:  20nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265377((S)-2-(3-((S)-1-Carboxy-5-(4-iodobenzylamino)penty...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097105(6-Bromo-2-(4-bromo-phenyl)-quinoline-4-carboxylic ...)
Affinity DataIC50:  25nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097106(2-(4-Bromo-phenyl)-8-chloro-6-methyl-quinoline-4-c...)
Affinity DataIC50:  25nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097090(2-(4-Bromo-phenyl)-6-chloro-quinoline-4-carboxylic...)
Affinity DataIC50:  26nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097086(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)
Affinity DataIC50:  30nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265378((S)-2-(3-((S)-1-Carboxy-5-(2-iodobenzylamino)penty...)
Affinity DataIC50:  37nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50143333((S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140709(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'S,6a'R)-...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140709(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'S,6a'R)-...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265380((S)-2-(3-((S)-1-Carboxy-5-(4-bromobenzylamino)pent...)
Affinity DataIC50:  43nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097113(2-(4-Bromo-phenyl)-6-trifluoromethoxy-quinoline-4-...)
Affinity DataIC50:  53nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50143329((S)-1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-y...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human methionyl-tRNA synthetase (fMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140707(5-(3-chloro-4-methylphenyl)-3-phenyl-(3R,3aS,6aR)-...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Staphylococcus aureusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097102(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)
Affinity DataIC50:  70nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50143334((S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-yli...)
Affinity DataIC50:  87nMAssay Description:Inhibition of Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097107(2-(4-Bromo-phenyl)-7-fluoro-8-methyl-quinoline-4-c...)
Affinity DataIC50:  120nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50129541(3-[5-(2',4'-Dichloro-biphenyl-4-yl)-3-tetrazol-1-y...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50129527(5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-yl-1H...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against human methionyl-tRNA synthetase (hMetRS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097091(2-(4-Bromo-phenyl)-5,7-dichloro-quinoline-4-carbox...)
Affinity DataIC50:  140nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097093(7-Bromo-2-(4-bromo-phenyl)-8-methyl-quinoline-4-ca...)
Affinity DataIC50:  150nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50129528(2-[5-(2',4'-Dichloro-biphenyl-4-yl)-3-tetrazol-1-y...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265489((S)-2-(3-((S)-1-Carboxy-5-(naphthalen-1-ylmethylam...)
Affinity DataIC50:  154nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50143331((S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z...)
Affinity DataIC50:  170nMAssay Description:Inhibition of Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase, mitochondrial(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140728(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Affinity DataIC50:  170nMAssay Description:Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50143337((S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-yli...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human methionyl-tRNA synthetase (fMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50143332((S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase, cytoplasmic(Candida albicans)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50097104(6-Bromo-2-(4-bromo-phenyl)-8-trifluoromethyl-quino...)
Affinity DataIC50:  220nMAssay Description:Aminoacylation activity against Candida albicans prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha subunit(Streptococcus pyogenes serotype M18)
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140707(5-(3-chloro-4-methylphenyl)-3-phenyl-(3R,3aS,6aR)-...)
Affinity DataIC50:  220nMAssay Description:Inhibitory activity against phenylalanyl-tRNA synthetase from Enterococcus faecalisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265391((S)-2-(3-((S)-1-Carboxy-5-(2-chlorobenzylamino)pen...)
Affinity DataIC50:  245nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase, mitochondrial(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140728(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Affinity DataIC50:  260nMAssay Description:Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Molecular Insight Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265451((S)-2-(3-((S)-1-Carboxy-5-(3-chlorobenzylamino)pen...)
Affinity DataIC50:  277nMAssay Description:Inhibition of [131I]DCIT from PSMA in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50129551(CHEMBL74224 | {[5-(2',4'-Dichloro-biphenyl-4-yl)-1...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50129534(5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-yl-1H...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human methionyl-tRNA synthetase (hMetRS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Arqule

Curated by ChEMBL
LigandPNGBDBM50143343((S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human methionyl-tRNA synthetase (fMetRS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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