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Found 69 with Last Name = 'kiyama' and Initial = 'r'
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031962(3-(5,7-Dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-y...)
Affinity DataKi:  0.290nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031954(3-(2-Cyclopropyl-5,7-dimethyl-imidazo[4,5-b]pyridi...)
Affinity DataKi:  0.450nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031953(3-(2-Ethyl-6-methoxy-[1,5]naphthyridin-4-yloxymeth...)
Affinity DataKi:  0.480nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031957(5,7-Dimethyl-2-propyl-3-[11-(1H-tetrazol-5-yl)-5H-...)
Affinity DataKi:  0.490nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031960(3-(2-Ethyl-quinolin-4-yloxymethyl)-11-(1H-tetrazol...)
Affinity DataKi:  0.650nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031961(3-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-yl...)
Affinity DataKi:  0.660nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031955(5,7-Dimethyl-2-propyl-3-[11-(1H-tetrazol-5-yl)-dib...)
Affinity DataKi:  0.700nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031964(3-[(5-Ethyl-pyrazolo[1,5-a]pyrimidin-7-ylamino)-me...)
Affinity DataKi:  1.10nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031956(3-(2-Ethyl-5,6,7,8-tetrahydro-quinolin-4-yloxymeth...)
Affinity DataKi:  1.30nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031959(2-Butyl-5-chloro-3-[5-oxo-11-(1H-tetrazol-5-yl)-5H...)
Affinity DataKi:  2.10nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031966(2-Ethoxy-3-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo...)
Affinity DataKi:  2.70nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031965(2-Ethyl-4-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dibenzo[...)
Affinity DataKi:  2.70nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031950(2,6-Dimethyl-4-{[5-oxo-11-(1H-tetrazol-5-yl)-5H-di...)
Affinity DataKi:  2.90nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031951(2-Ethoxy-3-[11-(1H-tetrazol-5-yl)-dibenzo[b,f]oxep...)
Affinity DataKi:  3.90nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031949(3-(2-Methyl-5,6,7,8-tetrahydro-quinolin-4-yloxymet...)
Affinity DataKi:  4.30nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031963(2,6-Dimethyl-4-[5-oxo-11-(1H-tetrazol-5-yl)-5H-dib...)
Affinity DataKi:  4.30nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031952((S)-3-Methyl-2-{[5-oxo-11-(1H-tetrazol-5-yl)-5H-di...)
Affinity DataKi:  8.70nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031958((S)-3-Methyl-2-{pentanoyl-[11-(1H-tetrazol-5-yl)-d...)
Affinity DataKi:  9.60nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50031948(2-Butyl-5-chloro-3-[5-oxo-11-(1H-tetrazol-5-yl)-5H...)
Affinity DataKi:  12nMAssay Description:Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077162((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Affinity DataIC50:  0.650nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077157((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50492496(Cabotegravir | GSK-1265744A | GSK1265744 | GSK1265...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077161((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Affinity DataIC50:  3.90nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077155((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077152((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077163((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Affinity DataIC50:  4.70nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50492497(CHEMBL2403118)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077158((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  5.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063164((R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfo...)
Affinity DataIC50:  5.90nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077157((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  7.30nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077162((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Affinity DataIC50:  8.20nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50:  9.60nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077164((R)-3-(1H-Indol-3-yl)-2-[5-(4-phenoxy-phenylethyny...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50485874(CHEMBL2171671)
Affinity DataIC50:  10nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using pre-incubation and wash with Mg2+ cofactor by ELISA based microtiter plate integration as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077152((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077149((R)-3-Methyl-2-[5-(4-phenoxy-phenylethynyl)-thioph...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50485875(CHEMBL2171670)
Affinity DataIC50:  18nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using pre-incubation and wash with Mg2+ cofactor by ELISA based microtiter plate integration as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077153((R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylami...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063164((R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfo...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077150((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063133((R)-3-Methyl-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benz...)
Affinity DataIC50:  72nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077159((R)-3-(1H-Indol-3-yl)-2-(5-o-tolylethynyl-thiophen...)
Affinity DataIC50:  81nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50485873(CHEMBL2171665)
Affinity DataIC50:  130nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using pre-incubation and wash with Mg2+ cofactor by ELISA based microtiter plate integration as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077158((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077163((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077149((R)-3-Methyl-2-[5-(4-phenoxy-phenylethynyl)-thioph...)
Affinity DataIC50:  260nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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