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Found 299 with Last Name = 'kwak' and Initial = 'y'
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataKi:  1nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataKi:  1nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET-based competitive binding assayMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86298(WKFMVm-NH2)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86301(WKWMVm-NH2)
Affinity DataKi:  19nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86299(WHYMVm-NH2)
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86297(WKYMVm-NH2)
Affinity DataKi:  47nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86308(WRYMVm-NH2)
Affinity DataKi:  55nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86300(WKYM(F/W)m-NH2)
Affinity DataKi:  57nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86302(WDYMVm-NH2)
Affinity DataKi:  99nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50085045(5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-...)
Affinity DataKi:  200nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86303(WKHMVm-NH2)
Affinity DataKi:  282nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)
Affinity DataKi:  300nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET-based competitive binding assayMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86306(WEYMVm-NH2)
Affinity DataKi:  323nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50614189(CHEMBL5280736)
Affinity DataKi:  370nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET-based competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50614188(CHEMBL5281325)
Affinity DataKi:  550nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET-based competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86305(YMVm-NH2)
Affinity DataKi:  567nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86307(WKYMYm-NH2)
Affinity DataKi:  671nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataKi:  1.08E+3nMAssay Description:Partial agonist activity at PPARgamma (unknown origin) by TR-FRET-based competitive binding assayMore data for this Ligand-Target Pair
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86304(WKDMVm-NH2)
Affinity DataKi:  1.30E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
Pohang University of Science and Technology

Curated by PDSP Ki Database
LigandPNGBDBM86296(WKEMVm-NH2)
Affinity DataKi:  1.30E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50593478(CHEMBL5188426)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50558309(CHEMBL4756611)
Affinity DataKi:  4.74E+3nMAssay Description:Competitive inhibition of cathepsin B (unknown origin) using varying level of RR-AMC as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50049391(3,5,7-Trihydroxyflavone | 3,5,7-triOH-flavone | 3,...)
Affinity DataKi:  5.60E+3nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50558309(CHEMBL4756611)
Affinity DataKi:  5.73E+3nMAssay Description:Competitive inhibition of human erythrocytes mu-calpain using varying level of Pep2 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Affinity DataKi:  7.86E+3nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET-based competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50558313(CHEMBL4740912)
Affinity DataKi:  1.06E+4nMAssay Description:Competitive inhibition of cathepsin B (unknown origin) using varying level of RR-AMC as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50300459(CHEMBL573709 | Kojic acid-phenylalanine amide)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50558313(CHEMBL4740912)
Affinity DataKi:  1.93E+4nMAssay Description:Competitive inhibition of human erythrocytes mu-calpain using varying level of Pep2 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataKi:  5.83E+5nMAssay Description:Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Dong-A Pharm.

Curated by ChEMBL
LigandPNGBDBM50344779((R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant human DPP-4 assessed as H-Gly-Pro-AMC cleavage after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Dong-A Pharm.

Curated by ChEMBL
LigandPNGBDBM50344783((S)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant human DPP-4 assessed as H-Gly-Pro-AMC cleavage after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50136226(CHEMBL3753341)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human wild type RET by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Dong-A Pharm.

Curated by ChEMBL
LigandPNGBDBM50344777((R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of recombinant human DPP-4 assessed as H-Gly-Pro-AMC cleavage after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50134785(CHEMBL3753512)
Affinity DataIC50:  2nMAssay Description:Inhibition of human wild type RET by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50136226(CHEMBL3753341)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Ret S891A mutant by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Dong-A Pharm.

Curated by ChEMBL
LigandPNGBDBM50344778((R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of recombinant human DPP-4 assessed as H-Gly-Pro-AMC cleavage after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM16509((2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarb...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of cathepsin B in human SH-SY5Y cells using RR-AMC as substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50136226(CHEMBL3753341)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Ret Y791F mutant by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of cathepsin L (unknown origin) using Z-FR-AMC as substrate preincubated for 30 mins followed by substrate addition and further incubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1 [89-488](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM120757(US8703761, 1-29)
Affinity DataIC50:  3.5nMpH: 7.5 T: 2°CAssay Description:The enzyme preparation used in this assay is a membrane preparation from Sf9 cells overexpressing human (His)6DGAT1. During all steps samples were ch...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin B(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM16509((2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarb...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of cathepsin B (unknown origin) using RR-AMC as substrate preincubated for 30 mins followed by substrate addition and further incubated fo...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50136226(CHEMBL3753341)
Affinity DataIC50:  4nMAssay Description:Inhibition of human Ret V804M mutant by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Dong-A Pharm.

Curated by ChEMBL
LigandPNGBDBM50344776((R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of recombinant human DPP-4 assessed as H-Gly-Pro-AMC cleavage after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50021574(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Ret S891A mutant by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50134786(CHEMBL3751904)
Affinity DataIC50:  5nMAssay Description:Inhibition of human wild type RET by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Dong-A Pharm.

Curated by ChEMBL
LigandPNGBDBM50344782((R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of recombinant human DPP-4 assessed as H-Gly-Pro-AMC cleavage after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50136226(CHEMBL3753341)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Ret M918T mutant by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute Of Science And Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50021574(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human Ret Y791F mutant by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143817(CHEMBL3758618)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant 6His-tagged DAGT1 expressed in fall armyworm Sf9 cells using diolein and oleoyl-CoA incubated for 30 mins by LC/MS/MS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Dong-A Pharm.

Curated by ChEMBL
LigandPNGBDBM50344775((R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butano...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of recombinant human DPP-4 assessed as H-Gly-Pro-AMC cleavage after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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