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Found 67 with Last Name = 'laganas' and Initial = 'va'
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231666(N-(2-(1H-indol-3-yl)ethyl)-3-(3-thiazol-2-ylureido...)
Affinity DataIC50:  2.20nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231665(1-(3-(4-(Pyridin-2-yl)piperazin-1-ylsulfonyl)pheny...)
Affinity DataIC50:  2.70nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Pseudomonas aeruginosa)
Astrazeneca R&D Boston

LigandPNGBDBM231666(N-(2-(1H-indol-3-yl)ethyl)-3-(3-thiazol-2-ylureido...)
Affinity DataIC50:  13nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Pseudomonas aeruginosa)
Astrazeneca R&D Boston

LigandPNGBDBM231665(1-(3-(4-(Pyridin-2-yl)piperazin-1-ylsulfonyl)pheny...)
Affinity DataIC50:  22nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131483(CHEMBL3632788)
Affinity DataIC50:  36nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131487(CHEMBL3634881)
Affinity DataIC50: <40nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131401(CHEMBL3632791)
Affinity DataIC50:  42nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131438(CHEMBL3632777)
Affinity DataIC50:  57nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131421(CHEMBL3632770)
Affinity DataIC50:  59nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231670(5-(3-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol...)
Affinity DataIC50:  60nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131484(CHEMBL3632789)
Affinity DataIC50:  68nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231674(N-(2-(1-(methylsulfonyl)cyclopropyl)ethyl)-2-(3-(5...)
Affinity DataIC50:  70nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131486(CHEMBL3634880)
Affinity DataIC50:  77nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231671(Ethyl 2-(3-(5-(trifluoromethyl)-1H-pyrazol-3-yl)ph...)
Affinity DataIC50:  80nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131412(CHEMBL3632794)
Affinity DataIC50:  84nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131485(CHEMBL3632790)
Affinity DataIC50:  100nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231669(2-[3-[(4-Chloro-2-pyridyl)amino]phenoxy]-N-(1,1-di...)
Affinity DataIC50:  100nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231676(2-((4-Chlorophenoxy)methyl)-N-(cyanomethyl)thiazol...)
Affinity DataIC50:  100nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131407(CHEMBL3632793)
Affinity DataIC50:  110nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131424(CHEMBL3632772)
Affinity DataIC50:  110nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131430(CHEMBL3632775)
Affinity DataIC50:  120nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131439(CHEMBL3632778)
Affinity DataIC50:  160nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131413(CHEMBL3632795)
Affinity DataIC50:  170nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231677(2-((4-Chlorophenoxy)methyl)-N-(2-sulfamoylethyl)th...)
Affinity DataIC50:  190nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131422(CHEMBL3632771)
Affinity DataIC50:  220nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131419(CHEMBL3632769)
Affinity DataIC50:  220nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131425(CHEMBL3632773)
Affinity DataIC50:  260nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131405(CHEMBL3632792)
Affinity DataIC50:  270nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131426(CHEMBL3632774)
Affinity DataIC50:  350nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131455(CHEMBL3632783)
Affinity DataIC50:  400nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131491(CHEMBL3634885)
Affinity DataIC50:  410nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131454(CHEMBL3632782)
Affinity DataIC50:  430nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131494(CHEMBL3634888)
Affinity DataIC50:  470nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131447(CHEMBL3632780)
Affinity DataIC50:  470nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131488(CHEMBL3634882)
Affinity DataIC50:  500nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131477(CHEMBL3632785)
Affinity DataIC50:  530nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131482(CHEMBL3632787)
Affinity DataIC50:  550nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231668(2-(3-(4-Cyanopyridin-2-ylamino)phenoxy)-N-methylac...)
Affinity DataIC50:  560nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131492(CHEMBL3634886)
Affinity DataIC50:  670nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131493(CHEMBL3634887)
Affinity DataIC50:  690nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131443(CHEMBL3632779)
Affinity DataIC50:  740nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131495(CHEMBL3632764)
Affinity DataIC50:  810nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131417(CHEMBL3632767)
Affinity DataIC50:  970nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231672(Ethyl 2-(3-(3-(difluoromethyl)-1H-pyrazol-5-yl)phe...)
Affinity DataIC50:  1.00E+3nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131448(CHEMBL3632781)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131416(CHEMBL3632766)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231675(N-(1,1-dioxothiolan-3-yl)-2-[(4-methylphenoxy)meth...)
Affinity DataIC50:  1.40E+3nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine--tRNA ligase alpha/beta subunit(Escherichia coli (Enterobacteria))
Astrazeneca R&D Boston

LigandPNGBDBM231667(2-(3-(4-Chloropyridin-2-ylamino)phenoxy)-N-methyla...)
Affinity DataIC50:  1.40E+3nMpH: 8.0Assay Description:Compounds were solubilized in DMSO. Serial 2-fold dilutions covering two concentration ranges, 10 mM to 19.5 μM and 100 μM to 195 nM, were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131457(CHEMBL3632784)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Staphylococcus aureus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50131490(CHEMBL3634884)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of Staphylococcus aureus NAD(+)-dependent DNA ligaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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