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Found 665 with Last Name = 'lindgren' and Initial = 'a'
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataKi:  370nMAssay Description:Displacement of [3H]BNZA from Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50568135(CHEMBL4849813)
Affinity DataKi:  2.02E+3nMAssay Description:Displacement of [3H]BNZA from Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145281(US8952169, 60 | US9771376, Example 60)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of full length human Nav1.7 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of full length human Nav1.7 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM71064(US9546164, 209 | US9694002, 209)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM145369(US8952169, 148 | US9771376, Example 148)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM145281(US8952169, 60 | US9771376, Example 60)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM70936(US9546164, 99 | US9694002, 99)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of mouse Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM145375(US8952169, 154)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM145376(US8952169, 155)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM70987(US9546164, 139 | US9694002, 139)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of mouse Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145374(US8952169, 153)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50587016(CHEMBL5091342)
Affinity DataIC50:  3.60nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of rat Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50587015(CHEMBL5082739)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50615672(CHEMBL5272143)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM145635(US8952169, 440)
Affinity DataIC50:  5.5nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.1 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -40 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145281(US8952169, 60 | US9771376, Example 60)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145623(US8952169, 426)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145266(US8952169, 45)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145382(US8952169, 161)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM70981(US9546164, 135 | US9694002, 135)
Affinity DataIC50:  7.70nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145438(US8952169, 217)
Affinity DataIC50:  8nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145374(US8952169, 153)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  9nMAssay Description:Inhibition of rat Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM71126(US9546164, 253 | US9694002, 253)
Affinity DataIC50:  9.80nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50615671(CHEMBL5279943)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145623(US8952169, 426)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145373(US8952169, 152 | US9771376, Example 152)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length human Nav1.1 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50:  12nMAssay Description:Inhibition of human Nav1.2 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530536(CHEMBL4580996 | US11174268, Example 336)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-1(Homo sapiens)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530536(CHEMBL4580996 | US11174268, Example 336)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human full length Nav1.2 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM145369(US8952169, 148 | US9771376, Example 148)
Affinity DataIC50:  14nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 1 hr in presence of veratridine by sodium influx assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145266(US8952169, 45)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145387(US8952169, 166 | US9771376, Example 166)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
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