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Found 958 with Last Name = 'long' and Initial = 'f'
TargetKallikrein-7(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50073221(CHEMBL3408420)
Affinity DataKi:  2.70E+4nMAssay Description:Competitive inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50073222(CHEMBL3125572)
Affinity DataKi:  5.06E+4nMAssay Description:Competitive inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320295((S)-1-(2-((2beta,3aR,5S,6aS)-5-methoxyoctahydropen...)
Affinity DataIC50:  8nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320285((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320301((S)-1-(2-((2beta,3aR,5S,6aS)-5-hydroxyoctahydropen...)
Affinity DataIC50:  12nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320294((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320293((3aR,5alpha,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)...)
Affinity DataIC50:  13nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320291((S)-1-(2-((3aR,5beta,6aS)-2-(2-hydroxyacetyl)octah...)
Affinity DataIC50:  14nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320300((S)-1-(2-((2alpha,3aR,5S,6aS)-5-methoxyoctahydrope...)
Affinity DataIC50:  23nMAssay Description:Inhibition of DPP8 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320290((3aR,5beta,6aS)-methyl 5-(2-((S)-2-cyanopyrrolidin...)
Affinity DataIC50:  24nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320299((S)-1-(2-((2alpha,3aR,5R,6aS)-5-methoxyoctahydrope...)
Affinity DataIC50:  27nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320306((S)-1-(2-((2beta,3aR,5R,6aS)-5-methoxyoctahydropen...)
Affinity DataIC50:  27nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320302((2S,3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-y...)
Affinity DataIC50:  32nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320299((S)-1-(2-((2alpha,3aR,5R,6aS)-5-methoxyoctahydrope...)
Affinity DataIC50:  37nMAssay Description:Inhibition of DPP9 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320300((S)-1-(2-((2alpha,3aR,5S,6aS)-5-methoxyoctahydrope...)
Affinity DataIC50:  37nMAssay Description:Inhibition of DPP9 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320287((3aR,5beta,6aS)-N-butyl-5-(2-((S)-2-cyanopyrrolidi...)
Affinity DataIC50:  39nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM212892(US9278960, 2-39 | US9663506, Example 2-39)
Affinity DataIC50:  45nMAssay Description:Negative allosteric modulation of mGlu2R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320300((S)-1-(2-((2alpha,3aR,5S,6aS)-5-methoxyoctahydrope...)
Affinity DataIC50:  47nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320289((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320296((S)-1-(2-((2beta,3aR,5S,6aS)-5-ethoxyoctahydropent...)
Affinity DataIC50:  59nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320297((2S,3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-y...)
Affinity DataIC50:  65nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320288((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  69nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM430126(4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataIC50:  78nMAssay Description:Negative allosteric modulation of mGlu2R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320298((2S,3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-y...)
Affinity DataIC50:  80nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320292((3aR,5alpha,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)...)
Affinity DataIC50:  83nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503469(CHEMBL4575990)
Affinity DataIC50:  87nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503469(CHEMBL4575990)
Affinity DataIC50:  87nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503465(CHEMBL4550009)
Affinity DataIC50:  102nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503465(CHEMBL4550009)
Affinity DataIC50:  102nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM602728(2-[1-(2-Isoindolin-2-yl-6-methyl-4-oxo-chromen-8-y...)
Affinity DataIC50:  110nMAssay Description:Recombinant, catalytically active human full length PIK3KA Wild-type and H1047R mutant were purchased as 1:1 complex of N-terminal 6×his tagged p110<...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320286((3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-yl)-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320305((2S,3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-y...)
Affinity DataIC50:  121nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM213122(US9278960, 8-29 | US9636337, 8-29)
Affinity DataIC50:  146nMAssay Description:Negative allosteric modulation of mGlu2R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503466(CHEMBL4569114)
Affinity DataIC50:  148nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503466(CHEMBL4569114)
Affinity DataIC50:  148nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetExportin-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50527779(CHEMBL4440028)
Affinity DataIC50:  151nMAssay Description:Inhibition of CRM1 in human HCT-15 cells assessed as reduction in cell viability incubated for 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50278653(CHEMBL4163186 | US10399948, Compound 20)
Affinity DataIC50:  180nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50278653(CHEMBL4163186 | US10399948, Compound 20)
Affinity DataIC50:  182nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320303((2S,3aR,5beta,6aS)-5-(2-((S)-2-cyanopyrrolidin-1-y...)
Affinity DataIC50:  204nMAssay Description:Inhibition of DPP4 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503463(CHEMBL4441595)
Affinity DataIC50:  207nMAssay Description:Negative allosteric modulation of mGlu2R (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503467(CHEMBL4533083)
Affinity DataIC50:  224nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503467(CHEMBL4533083)
Affinity DataIC50:  224nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50:  230nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50320299((S)-1-(2-((2alpha,3aR,5R,6aS)-5-methoxyoctahydrope...)
Affinity DataIC50:  235nMAssay Description:Inhibition of DPP8 by chemical luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50:  245nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50:  245nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50278634(CHEMBL4173490 | US10399948, Compound 23)
Affinity DataIC50:  269nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50278634(CHEMBL4173490 | US10399948, Compound 23)
Affinity DataIC50:  270nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50503464(CHEMBL4550517)
Affinity DataIC50:  288nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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