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Found 108 with Last Name = 'lukkarila' and Initial = 'jl'
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427034(CHEMBL2322194)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427035(CHEMBL2017005)
Affinity DataIC50:  10nMAssay Description:Inhibition of NAE (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427031(CHEMBL2322197)
Affinity DataIC50:  800nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed NEDD8-Ubcl2 intermediate formation by densitometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427035(CHEMBL2017005)
Affinity DataIC50:  920nMAssay Description:Inhibition of UBA6 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427034(CHEMBL2322194)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of UBA6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50240436(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of recombinant SAE1(unknown origin)-mediated SUMOylation of RanGAP1-C2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50242188(6-(8'Z-pentadecenyl)-salicylicacid | 6-[8'(Z)-pent...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of recombinant SAE1(unknown origin)-mediated SUMOylation of RanGAP1-C2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin-like modifier-activating enzyme 7(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427035(CHEMBL2017005)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of UBA7 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427032(6,6''-Biapigenin | CHEMBL2322196)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of NAE (unknown origin) assessed as decrease in NEDD8-Ubcl2 formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427035(CHEMBL2017005)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of SAE (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427034(CHEMBL2322194)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of SAE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin-like modifier-activating enzyme ATG7(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427034(CHEMBL2322194)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ATG7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427033(CHEMBL2322195 | Kerriamycin B)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibition of recombinant His-tagged SAE1(unknown origin)-mediated SUMOylation of RanGAP1-C2 by immunoblotting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50427032(6,6''-Biapigenin | CHEMBL2322196)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed transthiolation of NEDD8 from NAE to Ubc12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335439(2-(2-((tert-butoxycarbonyl)(4-cyclohexylbenzyl)ami...)
Affinity DataIC50:  2.72E+4nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335438(2-(2-((4-cyclohexylbenzyl)amino)-6-(isobutylamino)...)
Affinity DataIC50:  5.35E+4nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335434(2-(2-((4-cyclohexylbenzyl)amino)-6-(cyclopentylami...)
Affinity DataIC50:  5.74E+4nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335405(2-(2-(cyclohexanecarboxamido)-6-morpholino-9H-puri...)
Affinity DataIC50:  6.44E+4nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335432(2-(2-((4-cyclohexylbenzyl)amino)-6-((furan-2-ylmet...)
Affinity DataIC50:  7.44E+4nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335443(2-(2-((4-cyclohexylbenzyl)amino)-6-(4-nitrophenoxy...)
Affinity DataIC50:  7.97E+4nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335431(2-(2-((4-cyclohexylbenzyl)amino)-6-((4-fluoropheny...)
Affinity DataIC50:  8.36E+4nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335414(2-(6-(benzylamino)-2-(pentylamino)-9H-purin-9-yl)a...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335415(2-(6-(benzyl(methyl)amino)-2-(pentylamino)-9H-puri...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335416(2-(2-(pentylamino)-6-(phenylamino)-9H-purin-9-yl)a...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335417(2-(6-((furan-2-ylmethyl)(methyl)amino)-2-(pentylam...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335418(2-(6-(cyclopentylamino)-2-(pentylamino)-9H-purin-9...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335419(2-(6-(cyclohexylamino)-2-(pentylamino)-9H-purin-9-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335420(2-(6-(ethyl(methyl)amino)-2-(pentylamino)-9H-purin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335421(2-(6-(isopropylamino)-2-(pentylamino)-9H-purin-9-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335422(2-(6-(allylamino)-2-(pentylamino)-9H-purin-9-yl)ac...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335423(2-(6-(isobutylamino)-2-(pentylamino)-9H-purin-9-yl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335424(2-(6-(butyl(methyl)amino)-2-(pentylamino)-9H-purin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335425(2-(6-(isopentylamino)-2-(pentylamino)-9H-purin-9-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335426(2-(6-morpholino-2-(pentylamino)-9H-purin-9-yl)acet...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335427(2-(6-(3-nitrophenoxy)-2-(pentylamino)-9H-purin-9-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335428(2-(6-(4-nitrophenoxy)-2-(pentylamino)-9H-purin-9-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335429(2-(6-(benzylamino)-2-((4-cyclohexylbenzyl)amino)-9...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335430(2-(6-(benzyl(methyl)amino)-2-((4-cyclohexylbenzyl)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335433(2-(2-((4-cyclohexylbenzyl)amino)-6-((furan-2-ylmet...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335435(2-(6-(cyclohexylamino)-2-((4-cyclohexylbenzyl)amin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335436(2-(2-((tert-butoxycarbonyl)(4-cyclohexylbenzyl)ami...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335437(2-(6-(allylamino)-2-((4-cyclohexylbenzyl)amino)-9H...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335440(2-(2-((4-cyclohexylbenzyl)amino)-6-(hexylamino)-9H...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335441(2-(2-((4-cyclohexylbenzyl)amino)-6-morpholino-9H-p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335442(2-(2-((4-cyclohexylbenzyl)amino)-6-(3-nitrophenoxy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335444(2-(6-(3-bromophenoxy)-2-((4-cyclohexylbenzyl)amino...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335445(2-(2-((4-cyclohexylbenzyl)amino)-6-(4-fluorophenox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335400(2-(2-((4-cyclohexylbenzyl)amino)-6-(perfluoropheno...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335401(2-(2-(4-cyclohexylbenzylamino)-6-phenoxy-9H-purin-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50335402(2-(6-(benzylamino)-2-(4-cyclohexylbenzamido)-9H-pu...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse Stat3 DNA binding activity by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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