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Found 679 with Last Name = 'matsui' and Initial = 's'
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179532(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179555((S)-2-(biphenyl-3-ylamino)-4-methyl-pentanoic acid...)
Affinity DataIC50:  3.80nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179548(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)
Affinity DataIC50:  3.90nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179543((4-{(S)-2-[(S)-2-(biphenyl-3-ylamino)-4-methyl-pen...)
Affinity DataIC50:  4.5nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179539(CHEMBL383551 | [4-((S)-2-{[1-(biphenyl-3-ylamino)-...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179547(CHEMBL557986 | [4-((S)-2-{[1-(biphenyl-3-ylamino)-...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179542(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)
Affinity DataIC50:  5.60nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509364(CHEMBL4463968)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179558((4-{(S)-2-[(S)-2-(biphenyl-3-ylamino)-4-methyl-pen...)
Affinity DataIC50:  6.40nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509346(CHEMBL4470947)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179559((S)-2-(biphenyl-3-ylamino)-4-methyl-pentanoic acid...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179551(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179538((S)-2-(biphenyl-3-ylamino)-4-methyl-pentanoic acid...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509358(CHEMBL4534641)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509362(CHEMBL4483030)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509354(CHEMBL4542665)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509356(CHEMBL4584730)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509360(CHEMBL4538356)
Affinity DataIC50:  38nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179549((S)-2-(biphenyl-3-ylamino)-4-methyl-pentanoic acid...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509353(CHEMBL4546647)
Affinity DataIC50:  48nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50509350(CHEMBL4441993)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509351(CHEMBL4460077)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179556((S)-2-(3-cyclohexylphenylamino)-N-(2-(4-methoxyphe...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179560(CHEMBL383473 | N-(2-(4-methoxyphenylamino)ethyl)-4...)
Affinity DataIC50:  69nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179550(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179534(1-(biphenyl-3-ylamino)-cyclohexanecarboxylic acid ...)
Affinity DataIC50:  83nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509355(CHEMBL4551634)
Affinity DataIC50:  89nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50113676((S)-benzyl 1-(2-(4-methoxyphenylamino)ethylamino)-...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179537(2-(biphenyl-3-yloxy)-4-methyl-pentanoic acid [2-(4...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50535669(CHEMBL1233930)
Affinity DataIC50:  96nMAssay Description:Inhibition of His-tagged human MTHFD1 ( 1 to 306 residues) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before folitixorin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179553(1-(4-cyclohexylphenoxy)-N-(2-(4-methoxyphenylamino...)
Affinity DataIC50:  99nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179540(1-(biphenyl-4-ylamino)-cyclohexanecarboxylic acid ...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179561(2-(biphenyl-4-yloxy)-4-methyl-pentanoic acid [2-(4...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179557(1-(4-ethylphenoxy)-N-(2-(4-methoxyphenylamino)ethy...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509359(CHEMBL4474051)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179546(1-(biphenyl-4-yloxy)-cyclohexanecarboxylic acid [2...)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509352(CHEMBL4451401)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179536(1-(4-isopropylphenoxy)-N-(2-(4-methoxyphenylamino)...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179541(1-(biphenyl-3-yloxy)-cyclohexanecarboxylic acid [2...)
Affinity DataIC50:  320nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509363(CHEMBL4467997)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509344(CHEMBL4460238)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509347(CHEMBL4526400)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509348(CHEMBL4458187)
Affinity DataIC50:  360nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509343(CHEMBL4472668)
Affinity DataIC50:  390nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509342(CHEMBL4438430)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509345(CHEMBL4592118)
Affinity DataIC50:  530nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50509364(CHEMBL4463968)
Affinity DataIC50:  570nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50179545(CHEMBL203176 | N-(2-(4-methoxyphenylamino)ethyl)-4...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50535669(CHEMBL1233930)
Affinity DataIC50:  663nMAssay Description:Inhibition of His-tagged human MTHFD2 ( 36 to 350 residues) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before folitixorin and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50535650(CHEMBL4540255)
Affinity DataIC50:  940nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NAD and formaldehyde incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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