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Found 128 with Last Name = 'miles-williams' and Initial = 'a'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50354851(FLUTICASONE FUROATE | Veramyst)
Affinity DataIC50:  0.0398nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414604(CHEMBL551816)
Affinity DataIC50:  0.0790nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414609(CHEMBL550730)
Affinity DataIC50:  0.126nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414610(CHEMBL564160)
Affinity DataIC50:  0.200nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414607(CHEMBL563812)
Affinity DataIC50:  0.251nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414611(CHEMBL560797)
Affinity DataIC50:  0.251nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414605(CHEMBL556231)
Affinity DataIC50:  0.316nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414612(CHEMBL559115)
Affinity DataIC50:  0.316nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414608(CHEMBL550933)
Affinity DataIC50:  0.316nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414613(CHEMBL561475)
Affinity DataIC50:  0.398nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414615(CHEMBL559942)
Affinity DataIC50:  0.398nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414606(CHEMBL550258)
Affinity DataIC50:  0.501nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414618(CHEMBL563595)
Affinity DataIC50:  0.794nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414614(CHEMBL561276)
Affinity DataIC50:  0.794nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataIC50:  1nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414623(CHEMBL394168)
Affinity DataIC50:  1.58nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043224(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043221(3-Mercapto-6-methyl-4-(1-methylcarbamoyl-2-phenyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043231(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414619(CHEMBL559547)
Affinity DataIC50:  2.51nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043228(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414616(CHEMBL558716)
Affinity DataIC50:  3.16nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414617(CHEMBL559742)
Affinity DataIC50:  5.01nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414620(CHEMBL559546)
Affinity DataIC50:  7.94nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414604(CHEMBL551816)
Affinity DataIC50:  10nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414604(CHEMBL551816)
Affinity DataIC50:  10nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043227(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043237(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450368(CHEMBL2115216)
Affinity DataIC50:  12nMAssay Description:Inhibition of semi-purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450368(CHEMBL2115216)
Affinity DataIC50:  12nMAssay Description:Inhibition of semi-purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043222(4-(2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043222(4-(2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043235(2-(1-Mercapto-ethyl)-4-methyl-pentanoic acid [2-(4...)
Affinity DataIC50:  17nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286132((S)-2-((S)-1-Mercapto-ethyl)-4-methyl-pentanoic ac...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity was tested against human collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043242(3-Acetylsulfanyl-4-[2-(1H-indol-3-yl)-1-methylcarb...)
Affinity DataIC50:  19nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50283786(CHEMBL328917 | {(R)-3-(6-Bromo-1,3-dioxo-1H,3H-ben...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043231(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  21nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenase without beta-mercaptoethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043223(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  22nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043238(2-Isobutyl-3-mercapto-pentanedioic acid 5-amide 1-...)
Affinity DataIC50:  23nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043230(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414621(CHEMBL562337)
Affinity DataIC50:  25.1nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285719(CHEMBL315898 | N*4*-Hydroxy-2-isobutyl-N*1*-(2-oxo...)
Affinity DataIC50:  26nMAssay Description:Inhibition of semi-purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043229(CHEMBL130164 | {3-Mercapto-4-[2-(4-methoxy-phenyl)...)
Affinity DataIC50:  27nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50283785(CHEMBL98233 | {(R)-3-(1,3-Dioxo-1H,3H-benzo[de]iso...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286139((S)-2-(2-Mercapto-benzyl)-4-methyl-pentanoic acid ...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity was tested against human collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414609(CHEMBL550730)
Affinity DataIC50:  31.6nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414622(CHEMBL564332)
Affinity DataIC50:  31.6nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414609(CHEMBL550730)
Affinity DataIC50:  31.6nMAssay Description:Agonist activity at GR in human A549 cells by NF-kappaB transrepression assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043243(2-Isobutyl-3-mercapto-pentanedioic acid 5-carbamoy...)
Affinity DataIC50:  32nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043232(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  34nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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