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Found 3718 with Last Name = 'mori' and Initial = 'k'
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002099(CHEMBL366965 | Dimethyl-[3-(2-methyl-6H-dibenzo[b,...)
Affinity DataKi:  0.130nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(8-Benzyloxy-4-[(methyl-phenethyl-carbamoyl)-methyl...)
Affinity DataKi:  0.140nMAssay Description:Antagonistic activity of the compound against LTB4 receptor using guinea pig (GP) spleen cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]-JNJ962 from BACE1 (unknown origin) expressed in HEK293 cell membrane assessed as inhibition constant by scintillation counting a...More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002087(4-(1-Methyl-piperidin-4-ylidene)-4,9-dihydro-1-thi...)
Affinity DataKi:  0.310nMAssay Description:The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002083(2-[11-(3-Dimethylamino-propylidene)-6,11-dihydro-d...)
Affinity DataKi:  0.480nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002102(2-[11-(3-Dimethylamino-propylidene)-6,11-dihydro-d...)
Affinity DataKi:  0.630nMAssay Description:The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(8-Benzyloxy-4-[(methyl-phenethyl-carbamoyl)-methyl...)
Affinity DataKi:  2nMAssay Description:Antagonistic activity of the compound against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10870(2-N-(4-aminobenzene)-1,3,4-thiadiazole-2,5-disulfo...)
Affinity DataKi:  2nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10870(2-N-(4-aminobenzene)-1,3,4-thiadiazole-2,5-disulfo...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant CA2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11123((2S)-1-[(2S)-2-amino-3-[4-(2,4-difluorophenyl)phen...)
Affinity DataKi:  2.20nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptorMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataKi:  3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant CA2More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11121((2S)-1-[(2S)-2-amino-3-[4-(4-fluorophenyl)phenyl]p...)
Affinity DataKi:  3.10nM ΔG°:  -48.6kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002103(3-[11-(3-Dimethylamino-propylidene)-6,11-dihydro-d...)
Affinity DataKi:  4.20nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002095(11-(3-Dimethylamino-propylidene)-6,11-dihydro-dibe...)
Affinity DataKi:  4.20nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216147(CHEMBL134237)
Affinity DataKi:  4.30nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002085(CHEMBL304185 | [11-(4-Dimethylamino-butylidene)-6,...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002086(11-(3-Pyrrolidin-1-yl-propylidene)-6,11-dihydro-di...)
Affinity DataKi:  5nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002093(CHEMBL65699 | [11-(3-Dimethylamino-propylidene)-6,...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM11122((2S)-1-[(2S)-2-amino-3-[4-(2-fluorophenyl)phenyl]p...)
Affinity DataKi:  5.30nM ΔG°:  -47.2kJ/molepH: 7.4 T: 2°CAssay Description:The progress of DPPIV inhibition by compounds was measured by recording the liberation of free pNA at 405 nm. IC50 was determined from the slope of r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002097(11-(4-Dimethylamino-butylidene)-6,11-dihydro-diben...)
Affinity DataKi:  5.80nMAssay Description:The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10870(2-N-(4-aminobenzene)-1,3,4-thiadiazole-2,5-disulfo...)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10870(2-N-(4-aminobenzene)-1,3,4-thiadiazole-2,5-disulfo...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant CA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
Shionogi

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]CP55940 from mouse CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002098(11-(4-Dimethylamino-butylidene)-6,11-dihydro-diben...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50040108(11-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethylsulfa...)
Affinity DataKi:  6.90nMAssay Description:Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215950(CHEMBL55046)
Affinity DataKi:  7nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]CP55940 from mouse CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215392(CHEMBL131565)
Affinity DataKi:  7.5nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002092(11-(3-Thiomorpholin-4-yl-propylidene)-6,11-dihydro...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant CA2More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  8nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataKi:  9nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)
Affinity DataKi:  9nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant CA2More data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50213617((Z)-methyl 2-(2-isopropylphenylimino)-5,5-dimethyl...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50213617((Z)-methyl 2-(2-isopropylphenylimino)-5,5-dimethyl...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]CP55940 from mouse CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant CA2More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002084(11-(2-Dimethylamino-ethylsulfanyl)-6,11-dihydro-di...)
Affinity DataKi:  9nMAssay Description:Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  10nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant CA2More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50040114(CHEMBL336198 | {11-[2-(4-Benzyl-piperidin-1-yl)-et...)
Affinity DataKi:  10nMAssay Description:Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002100(11-(3-Diethylamino-propylidene)-6,11-dihydro-diben...)
Affinity DataKi:  10nMAssay Description:Binding affinity for histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002088(CHEMBL302005 | [11-(2-Dimethylamino-ethylidene)-6,...)
Affinity DataKi:  11nMAssay Description:Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002088(CHEMBL302005 | [11-(2-Dimethylamino-ethylidene)-6,...)
Affinity DataKi:  11nMAssay Description:The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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