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Found 1106 with Last Name = 'morriello' and Initial = 'g'
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096823((S)-6-Amino-2-[(S)-2-[(1-benzoyl-piperidine-4-carb...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound to Somatostatin receptor type 2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576278(CHEMBL4863002)
Affinity DataKi:  0.920nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576275(CHEMBL4873599)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576279(CHEMBL4871796)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442759(6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...)
Affinity DataKi:  1.5nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576271(CHEMBL4877091)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM385964(US10287293, Example 13 | US10287293, Example 14)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096830((S)-6-Amino-2-[(S)-2-({1-[2-(3,5-difluoro-phenyl)-...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096824((S)-6-Amino-2-[(S)-2-[(1-benzyl-piperidine-4-carbo...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity of the compound to Somatostatin receptor type 2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576277(CHEMBL4878348)
Affinity DataKi:  2.60nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096829((S)-6-Amino-2-[(S)-2-{[1-(2-hydroxy-2,2-diphenyl-a...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096835((S)-6-Amino-2-[(S)-2-{[1-(3,4-difluoro-benzyl)-pip...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50452209(CHEMBL4207777 | US10647727, Example 9)
Affinity DataKi:  3.40nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM442759(6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...)
Affinity DataKi:  3.80nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50452209(CHEMBL4207777 | US10647727, Example 9)
Affinity DataKi:  4.30nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096822((S)-6-Amino-2-[(S)-2-[(1-benzyl-piperidine-3-carbo...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM442769(N,1,6-Trimethyl-N-{1-[4-(trifluoromethyl)phenyl]cy...)
Affinity DataKi:  4.90nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096812((S)-6-Amino-2-[(S)-2-{[1-(3-fluoro-benzyl)-piperid...)
Affinity DataKi:  5nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096810((S)-6-Amino-2-[(S)-2-[(1-diphenylacetyl-piperidine...)
Affinity DataKi:  5nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50452200(CHEMBL4212416 | US10647727, Example 20)
Affinity DataKi:  5.5nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096816((S)-6-Amino-2-[(S)-2-{[1-(2,3-difluoro-benzyl)-pip...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442759(6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...)
Affinity DataKi:  6nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50452200(CHEMBL4212416 | US10647727, Example 20)
Affinity DataKi:  6.10nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM385962(US10287293, Example 11 | US10287293, Example 12)
Affinity DataKi:  7nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096821((S)-6-Amino-2-[(S)-2-[(1-cyclohexylcarbamoyl-piper...)
Affinity DataKi:  7.20nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50452200(CHEMBL4212416 | US10647727, Example 20)
Affinity DataKi:  8.40nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096820((S)-6-Amino-2-((S)-3-(1H-indol-3-yl)-2-{[1-((S)-1-...)
Affinity DataKi:  8.60nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096831((S)-6-Amino-2-((S)-3-(1H-indol-3-yl)-2-{[1-(3-meth...)
Affinity DataKi:  9nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096811((S)-6-Amino-2-[(S)-2-[(1-benzoyl-piperidine-3-carb...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096832((S)-6-Amino-2-[(S)-2-{[1-(2-benzo[1,3]dioxol-5-yl-...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096827((S)-6-Amino-2-((S)-3-(1H-indol-3-yl)-2-{[1-(3-meth...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096804((S)-6-Amino-2-{(S)-3-(1H-indol-3-yl)-2-[(1-phenylc...)
Affinity DataKi:  11nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096819(3-{3-[(S)-1-((S)-5-Amino-1-tert-butoxycarbonyl-pen...)
Affinity DataKi:  11nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096833((S)-6-Amino-2-[(S)-2-{[1-(4-fluoro-benzenesulfonyl...)
Affinity DataKi:  11nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096834((S)-6-Amino-2-[(S)-2-{[1-(4-chloro-benzo[1,3]dioxo...)
Affinity DataKi:  12nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096836((S)-6-Amino-2-((S)-3-(1H-indol-3-yl)-2-{[1-(thioph...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM385952(US10287293, Example 1 | US10287293, Example 2)
Affinity DataKi:  15nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096825((S)-6-Amino-2-{(S)-3-(1H-indol-3-yl)-2-[(1-isobuty...)
Affinity DataKi:  15nMAssay Description:Binding affinity of the compound to Somatostatin receptor type 2 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM442766(1,6-Dimethyl-N- (1-{4- [(trifluoromethyl)- sulfany...)
Affinity DataKi:  16nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096809((S)-6-Amino-2-{(S)-3-(1H-indol-3-yl)-2-[(1-naphtha...)
Affinity DataKi:  17nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442766(1,6-Dimethyl-N- (1-{4- [(trifluoromethyl)- sulfany...)
Affinity DataKi:  20nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50452216(CHEMBL4215537 | US10647727, Example 13)
Affinity DataKi:  20nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096815((S)-6-Amino-2-[(S)-2-[(1-biphenyl-2-ylmethyl-piper...)
Affinity DataKi:  21nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096813((S)-6-Amino-2-((S)-3-(1H-indol-3-yl)-2-{[1-(3-meth...)
Affinity DataKi:  23nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096808((S)-6-Amino-2-[(S)-2-{[1-(3,4-dimethoxy-benzenesul...)
Affinity DataKi:  23nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576272(CHEMBL4867001)
Affinity DataKi:  27nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50576268(CHEMBL4853336)
Affinity DataKi:  27nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187039(1-(3,4-dichlorobenzyl)-5-hydroxy-1H-indole-2-carbo...)
Affinity DataKi:  29nMAssay Description:Displacement of [125I]MCP1 from human CCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM442767(N-{1-[2-Fluoro-4- (trifluoromethyl)- phenyl]cyclo-...)
Affinity DataKi:  29nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096805((S)-6-Amino-2-[(S)-2-[(1-benzhydryl-piperidine-3-c...)
Affinity DataKi:  31nMAssay Description:Binding affinity to human somatostatin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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