Found 164 with Last Name = 'natale' and Initial = 'j' TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataKi: 4.40nMAssay Description:Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataKi: 92nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat hippocampal alpha7 nAChR measured after 2 hrs by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 620nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 860nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 3.22E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+3nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.10E+3nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: >1.20E+4nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 1.45E+4nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as decrease in calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
