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Found 2794 with Last Name = 'neagu' and Initial = 'c'
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of DPP4 in rat plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi:  14nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataKi:  1.10E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50463725(CHEMBL4242598)
Affinity DataKi:  2.20E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of DPP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of FAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50338518(1-((3S,4S)-4-amino-1-(4-(3,3-difluoropyrrolidin-1-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of DPP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182699(US9145392, 400)
Affinity DataIC50:  0.0600nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50466323(CHEMBL4279353)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus expression system using FITC-AHA-E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182489(US9145392, 190)
Affinity DataIC50:  0.100nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50466316(CHEMBL4276669)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus expression system using FITC-AHA-E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182489(US9145392, 190)
Affinity DataIC50:  0.100nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182480(US9145392, 181)
Affinity DataIC50:  0.110nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182480(US9145392, 181)
Affinity DataIC50:  0.150nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human full length BTK using FITC-AHA-EEPLYWSFPAKKK-NH2 as substrate after 90 mins by microfluid mobility shift assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182671(US9145392, 372)
Affinity DataIC50:  0.200nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182551(US9145392, 252)
Affinity DataIC50:  0.200nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus expression system using FITC-AHA-E...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50571038(CHEMBL4868813)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182483(US9145392, 184)
Affinity DataIC50:  0.260nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182699(US9145392, 400)
Affinity DataIC50:  0.300nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50466325(CHEMBL4279430)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus expression system using FITC-AHA-E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM514956(US11098041, Example 187)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM514891(US11098041, Example 116)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182673(US9145392, 374)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182551(US9145392, 252)
Affinity DataIC50:  0.400nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM514887(US11098041, Example 112)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50571039(CHEMBL4877846)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM514935(US11098041, Example 165)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182473(US9145392, 174)
Affinity DataIC50:  0.440nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM514915(US11098041, Example 144)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182624(US9145392, 325)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182535(US9145392, 236)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50571033(CHEMBL4876326)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM514904(US11098041, Example 132)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182425(US9145392, 126)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50466328(CHEMBL4290540)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus expression system using FITC-AHA-E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182473(US9145392, 174)
Affinity DataIC50:  0.520nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50571037(CHEMBL4862532)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182517(US9145392, 218)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182470(US9145392, 171)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182305(US9145392, 6)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182586(US9145392, 287)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50466206(CHEMBL4281335)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus expression system using FITC-AHA-E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50463725(CHEMBL4242598)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human full length BTK using FITC-AHA-EEPLYWSFPAKKK-NH2 as substrate after 90 mins by microfluid mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50571029(CHEMBL4855860)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM514897(US11098041, Example 124)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM182688(US9145392, 389)
Affinity DataIC50:  0.700nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...More data for this Ligand-Target Pair
In DepthDetails US Patent
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