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Found 1036 with Last Name = 'nemoto' and Initial = 'p'
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  0.690nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.00029-0.001More data for this Ligand-Target Pair
In DepthDetails Article
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50262010(CHEMBL4080876)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50262004(CHEMBL4088763)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50261945(CHEMBL4088331)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50262000(CHEMBL4071532)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078035(CHEMBL3417429)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26831(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191235(US9181272, 5)
Affinity DataIC50:  2nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26857(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26847(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26843(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26840(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  2nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191250(US9181272, 20)
Affinity DataIC50:  2nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin G(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50349174(CHEMBL1807526)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human cathepsin G after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50261982(CHEMBL4094923)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078033(CHEMBL3417431)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191414(US9181272, 184 | US9181272, 195 | US9181272, 196)
Affinity DataIC50:  2.60nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191361(US9181272, 131)
Affinity DataIC50:  2.70nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50261985(CHEMBL4072041)
Affinity DataIC50:  2.90nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50274339(CHEMBL485607 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26854(N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoyleth...)
Affinity DataIC50:  3nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50274045(3-[2-[2-(4-Cyano-phenyl)-2-oxo-ethyl]-5-(2-cyclohe...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50261946(CHEMBL4080469)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191255(US9181272, 25)
Affinity DataIC50:  3.10nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50261928(CHEMBL4080822)
Affinity DataIC50:  3.10nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191385(US9181272, 155)
Affinity DataIC50:  3.10nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191522(US9181272, 292)
Affinity DataIC50:  3.20nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM125960(US8772304, 22)
Affinity DataIC50:  3.20nMpH: 7.5Assay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191519(US9181272, 289)
Affinity DataIC50:  3.20nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191372(US9181272, 142)
Affinity DataIC50:  3.30nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191346(US9181272, 116)
Affinity DataIC50:  3.5nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078060(CHEMBL3417511)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of FLAP in calcimycin-stimulated human whole blood assessed as reduction in LTB4 production pretreated for 15 mins followed by calcimycin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191239(US9181272, 9)
Affinity DataIC50:  3.60nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191366(US9181272, 136)
Affinity DataIC50:  3.60nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50262005(CHEMBL4092404)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of FLAP in calcimycin-stimulated human whole blood assessed as reduction in LTB4 production pretreated for 15 mins followed by calcimycin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191494(US9181272, 264)
Affinity DataIC50:  3.70nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM336943(US9745289, Compound 59A | US9745289, Compound 59B)
Affinity DataIC50:  4nMAssay Description:Assays are performed in 96-well format in a final volume of 60 μL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191268(US9181272, 38)
Affinity DataIC50:  4nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50274669(CHEMBL485031 | N-(1-(3-(1H-imidazol-1-yl)propyl)-5...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50274340(CHEMBL483403 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50274470(CHEMBL485555 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50274471(CHEMBL485556 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50262021(CHEMBL4103286)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM125961(US8772304, 23)
Affinity DataIC50:  4nMpH: 7.5Assay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191467(US9181272, 237)
Affinity DataIC50:  4.10nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM125940(US8772304, 2)
Affinity DataIC50:  4.20nMpH: 7.5Assay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191414(US9181272, 184 | US9181272, 195 | US9181272, 196)
Affinity DataIC50:  4.30nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191458(US9181272, 228)
Affinity DataIC50:  4.30nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191489(US9181272, 259)
Affinity DataIC50:  4.40nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 family 11 subfamily B member 2(Cercopithecus sabaeus)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191374(US9181272, 144)
Affinity DataIC50:  4.60nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondr...More data for this Ligand-Target Pair
In DepthDetails US Patent
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