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Found 40 with Last Name = 'nixon' and Initial = 'gl'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50113463(CHEMBL537586)
Affinity DataIC50:  9nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
LigandPNGBDBM466327(US10799494, Compound CK-2-88)
Affinity DataIC50:  20nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  22nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  25nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as dextromethorphan O-demethylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
LigandPNGBDBM466330(US10799494, Compound PG-203)
Affinity DataIC50:  70nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466340(US10799494, Example WDH-2G-6)
Affinity DataIC50:  82nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466333(US10799494, Compound LT-9)
Affinity DataIC50:  100nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466310(US10799494, Compound CK-3-22)
Affinity DataIC50:  140nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466334(US10799494, Compound GN-1710)
Affinity DataIC50:  250nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466326(US10799494, Compound MTD-403)
Affinity DataIC50:  270nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466336(US10799494, Compound SL-2-25)
Affinity DataIC50:  290nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466332(US10799494, Compound RKA-73)
Affinity DataIC50:  310nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466341(US10799494, Example WDH-2R-4)
Affinity DataIC50:  380nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466316(US10799494, Compound RKA-307)
Affinity DataIC50:  440nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50273689(CHEMBL4128999)
Affinity DataIC50:  480nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50090677(4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfon...)
Affinity DataIC50:  720nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as tolbutamide methylhydroxylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM466331(US10799494, Compound RKA-70)
Affinity DataIC50:  750nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466320(US10799494, Compound RKA-310)
Affinity DataIC50:  1.40E+3nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466342(US10799494, Example RKA 142)
Affinity DataIC50:  2.02E+3nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466314(US10799494, Compound RKA-259)
Affinity DataIC50:  3.60E+3nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50236897(3-(furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM466328(US10799494, Compound CK-3-23)
Affinity DataIC50:  3.60E+3nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466335(US10799494, Compound PG-128)
Affinity DataIC50:  4.47E+3nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466339(US10799494, Compound WDH-2A-9)
Affinity DataIC50:  6.50E+3nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466337(US10799494, Compound WDH-1U-10)
Affinity DataIC50:  6.50E+3nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466329(US10799494, Compound CK-2-63)
Affinity DataIC50:  6.50E+3nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466311(US10799494, Compound CK-3-14)
Affinity DataIC50:  1.06E+4nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM466338(US10799494, Compound WDH-1W-5)
Affinity DataIC50:  1.58E+4nMAssay Description:The Mtb cytochrome bd inhibition assay described in accompanying Example section, or elsewhere in the literature, may be used to measure the pharmaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50273688(CHEMBL4127539)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as tolbutamide methylhydroxylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50273688(CHEMBL4127539)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50273688(CHEMBL4127539)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50273688(CHEMBL4127539)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50273688(CHEMBL4127539)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50273688(CHEMBL4127539)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as dextromethorphan O-demethylation after 4 to 40 mins in presence of NADPH by LCMS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Liverpool

Curated by ChEMBL
LigandPNGBDBM50265389(CHEMBL4080076)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138759(5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of HSL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138759(5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHormone-sensitive lipase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138751(5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of HSL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138751(5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...)
Affinity DataIC50: >5.00E+7nMAssay Description:Inhibition of human AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed