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Found 122 with Last Name = 'orr' and Initial = 'gf'
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1803(2-Amino-6-arylthiobenzonitrile deriv. 3w | 2-amino...)
Affinity DataIC50:  3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1804(2-Amino-6-arylthiobenzonitrile deriv. 3x | 2-amino...)
Affinity DataIC50:  5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1802(2-Amino-6-arylthiobenzonitrile deriv. 3v, 739W94 |...)
Affinity DataIC50:  7nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1805(2-Amino-6-arylthiobenzonitrile deriv. 3y | 2-amino...)
Affinity DataIC50:  10nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030972(5-(3-sec-Butoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)...)
Affinity DataIC50:  27nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1778(2-Amino-6-arylthiobenzonitrile deriv. 3ff | 2-amin...)
Affinity DataIC50:  30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1801(2-Amino-6-arylthiobenzonitrile deriv. 3u | 2-amino...)
Affinity DataIC50:  30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1806(2-Amino-6-arylthiobenzonitrile deriv. 3z | 2-amino...)
Affinity DataIC50:  40nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031005(1-(2-Hydroxy-ethoxymethyl)-5-(3-propoxy-benzyl)-1H...)
Affinity DataIC50:  47nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030974(1-(2-Hydroxy-1-hydroxymethyl-ethoxymethyl)-5-(3-pr...)
Affinity DataIC50:  60nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031009(1-(2-Hydroxy-ethoxymethyl)-5-(3-isobutoxy-benzyl)-...)
Affinity DataIC50:  66nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030990(5-[3-(3-Fluoro-propoxy)-benzyl]-1-(2-hydroxy-ethox...)
Affinity DataIC50:  68nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030980(1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL...)
Affinity DataIC50:  84nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031006(5-(3-Ethoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031007(5-[3-(3-Fluoro-propoxy)-benzyl]-1-(2-hydroxy-1-hyd...)
Affinity DataIC50:  110nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030999(5-(3-Chloro-benzyl)-1-(2-hydroxy-1-hydroxymethyl-e...)
Affinity DataIC50:  110nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1751(2-Amino-6-arylthiobenzonitrile deriv. 1u | 2-amino...)
Affinity DataIC50:  120nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030983(5-(3-Allyloxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1...)
Affinity DataIC50:  130nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1753(2-Amino-6-arylthiobenzonitrile deriv. 1w | 2-amino...)
Affinity DataIC50:  140nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030995(5-(3-Butoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031004(1-(2-Hydroxy-ethoxymethyl)-5-(3-isopropoxy-benzyl)...)
Affinity DataIC50:  160nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1792(2-Amino-6-arylthiobenzonitrile deriv. 3l | 2-amino...)
Affinity DataIC50:  200nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50122955(2-(4,6-Difluoro-indan-1-ylidene)-acetamide | CHEMB...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration of the compound against Monoamine oxidase B (MAO-B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1786(2-Amino-6-arylthiobenzonitrile deriv. 3f | 2-amino...)
Affinity DataIC50:  200nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1800(2-Amino-6-arylthiobenzonitrile deriv. 3t | 2-amino...)
Affinity DataIC50:  300nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030984(5-(3-Chloro-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030981(5-(3,5-Difluoro-benzyl)-1-(2-hydroxy-ethoxymethyl)...)
Affinity DataIC50:  350nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1789(2-Amino-6-arylthiobenzonitrile deriv. 3i | 2-amino...)
Affinity DataIC50:  400nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1776(2-Amino-6-arylthiobenzonitrile deriv. 3dd | 2-amin...)
Affinity DataIC50:  400nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50026387(1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4...)
Affinity DataIC50:  460nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1769(2-Amino-6-arylthiobenzonitrile deriv. 2n | 2-amino...)
Affinity DataIC50:  500nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1771(2-Amino-6-arylthiobenzonitrile deriv. 2p | 2-amino...)
Affinity DataIC50:  520nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030976(5-(3-Fluoro-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)
Affinity DataIC50:  550nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1783(2-Amino-6-arylthiobenzonitrile deriv. 3c | 2-amino...)
Affinity DataIC50:  600nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031001(5-(3-Propoxy-benzyl)-1H-pyrimidine-2,4-dione | CHE...)
Affinity DataIC50:  840nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030975(5-(2-Fluoro-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)
Affinity DataIC50:  870nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1772(2-Amino-6-arylthiobenzonitrile deriv. 2q | 2-amino...)
Affinity DataIC50:  900nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1736(2-Amino-6-arylthiobenzonitrile deriv. 1f | 2-amino...)
Affinity DataIC50:  960nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1777(2-(4a,8a-dihydronaphthalene-1-sulfonyl)-6-aminoben...)
Affinity DataIC50:  1.00E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1750(2-Amino-6-arylthiobenzonitrile deriv. 1t | 2-amino...)
Affinity DataIC50:  1.10E+3nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031000(5-(3-sec-Butoxy-benzyl)-1H-pyrimidine-2,4-dione | ...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1745(2-Amino-6-arylthiobenzonitrile deriv. 1o | 2-amino...)
Affinity DataIC50:  1.10E+3nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031002(5-(3-Isobutoxy-benzyl)-1H-pyrimidine-2,4-dione | C...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1782(2-Amino-6-arylthiobenzonitrile deriv. 3b | 2-amino...)
Affinity DataIC50:  1.40E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031012(5-[3-(3-Fluoro-propoxy)-benzyl]-1H-pyrimidine-2,4-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1733(2-Amino-6-arylthiobenzonitrile deriv. 1c | 2-amino...)
Affinity DataIC50:  1.50E+3nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1752(2-Amino-6-arylthiobenzonitrile deriv. 1v | 2-amino...)
Affinity DataIC50:  1.70E+3nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1797(2-Amino-6-arylthiobenzonitrile deriv. 3q | 2-amino...)
Affinity DataIC50:  1.80E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50031010(1-(2-Hydroxy-ethoxymethyl)-5-(3-methoxy-benzyl)-1H...)
Affinity DataIC50:  1.86E+3nMAssay Description:The compound was tested for inhibition of uridine phosphorylase (UrdPase) from murine liver Value refers to activity for apparent Ki valueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50030992(5-(3-Isopropoxy-benzyl)-1H-pyrimidine-2,4-dione | ...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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