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Found 178 with Last Name = 'ozasa' and Initial = 'h'

Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

IC50: 0.150nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566781(CHEMBL4867273)

IC50: 0.150nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566783(CHEMBL4859806)

IC50: 0.400nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566776(CHEMBL4847740)

IC50: 0.470nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566783(CHEMBL4859806)

IC50: 0.620nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566782(CHEMBL4857394)

IC50: 0.930nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566782(CHEMBL4857394)

IC50: 0.950nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566772(CHEMBL4878738)

IC50: 1.10nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566776(CHEMBL4847740)

IC50: 1.20nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566772(CHEMBL4878738)

IC50: 1.30nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566784(CHEMBL4872872)

IC50: 1.90nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566784(CHEMBL4872872)

IC50: 2nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566775(CHEMBL4856854)

IC50: 5.80nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566786(CHEMBL4866114)

IC50: 12nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566777(CHEMBL4848464)

IC50: 13nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566777(CHEMBL4848464)

IC50: 14nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566773(CHEMBL4853328)

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566773(CHEMBL4853328)

IC50: 18nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566775(CHEMBL4856854)

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566771(CHEMBL4859039)

IC50: 23nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566759(CHEMBL4868588)

IC50: 25nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566759(CHEMBL4868588)

IC50: 28nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566771(CHEMBL4859039)

IC50: 36nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566785(CHEMBL4868364)

IC50: 40nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566765(CHEMBL4849636)

IC50: 42nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566774(CHEMBL4858283)

IC50: 45nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566785(CHEMBL4868364)

IC50: 52nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566770(CHEMBL4863816)

IC50: 58nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566770(CHEMBL4863816)

IC50: 61nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566780(CHEMBL4860372)

IC50: 73nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566765(CHEMBL4849636)

IC50: 96nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566766(CHEMBL4875414)

IC50: 108nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566760(CHEMBL4870987)

IC50: 125nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566780(CHEMBL4860372)

IC50: 141nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566764(CHEMBL4873940)

IC50: 145nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566766(CHEMBL4875414)

IC50: 188nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Lysine-specific demethylase 2A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL

BDBM50324535(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)

IC50: 200nMAssay Description:Inhibition of KDM2A (unknown origin)More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566779(CHEMBL4878905)

IC50: 213nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566774(CHEMBL4858283)

IC50: 214nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566760(CHEMBL4870987)

IC50: 217nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566762(CHEMBL4851654)

IC50: 217nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566786(CHEMBL4866114)

IC50: 243nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566764(CHEMBL4873940)

IC50: 253nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566779(CHEMBL4878905)

IC50: 263nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Mus musculus)
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566762(CHEMBL4851654)

IC50: 277nMAssay Description:Inhibition of mouse recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566767(CHEMBL4856886)

IC50: 648nMAssay Description:Inhibition of human recombinant NNMT using nicotinamide and SAM as substrate assessed as reduction in 1-methyl-nicotinamide formation incubated for 2...More data for this Ligand-Target Pair

PDB Reactome pathway
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Nicotinamide N-methyltransferase(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL

BDBM50566784(CHEMBL4872872)

IC50: 770nMAssay Description:Inhibition of human NNMT expressed in HEK293 cells assessed as reduction in 1-methyl-nicotinamide formation measured after 24 hrs by RapidFire Mass s...More data for this Ligand-Target Pair

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Lysine-specific demethylase 4A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL

BDBM50324535(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)

IC50: 800nMAssay Description:Inhibition of KDM4A (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 4C(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL

BDBM50324535(3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propa...)

IC50: 1.00E+3nMAssay Description:Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 4C(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL

BDBM50324529(3-({9-[Benzyl(methyl)]amino}nonanoyl(hydroxy)amino...)

IC50: 1.30E+3nMAssay Description:Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assayMore data for this Ligand-Target Pair

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Displayed 1 to 50 (of 178 total ) | Next | Last >>

Filter my 178 hits

Targets 15▿
- Nicotinamide N-methyltransferase 62
- Lysine-specific demethylase 4A 27
- Lysine-specific demethylase 4C 27
- Lysine-specific demethylase 5A 12
- Lysine-specific demethylase 2A 11
- Lysine-specific demethylase 6A 9
- Prolyl hydroxylase EGLN2 8
- Egl nine homolog 1 8
- Cytochrome P450 2C19 4
- Cytochrome P450 1A2 2
- Cytochrome P450 2C9 2
- Cytochrome P450 2D6 2
- Cytochrome P450 3A4 2
- 5'-AMP-activated protein kinase subunit beta-2 1
- 5'-AMP-activated protein kinase subunit beta-1 1
- ...
Publications 4▿
- ACS Med Chem Lett 12: 1093-1101 (2021) 62
- J Med Chem 56: 7222-31 (2013) 56
- J Med Chem 53: 5629-38 (2010) 46
- Bioorg Med Chem Lett 68: (2022) 14
Institutions 4▿
- Shionogi Pharmaceutical Research Center 62
- Kyoto Prefectural University Of Medicine 56
- Nagoya City University 46
- Shionogi 14
Affinity: 0.15 to 3.3E+6 nM▿
- IC50 176
- EC50 2
- Affinity ≤ nM
Xtal structures: 3
Docked structures: 0
Catalog Cmpds: 4