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Found 68 with Last Name = 'pauly' and Initial = 'ta'
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29864(N-(Pyridin-2-yl) arylsulfonamide, 26)
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29863(N-(Pyridin-2-yl) arylsulfonamide, 25)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29862(N-(Pyridin-2-yl) arylsulfonamide, 24)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29860(N-(Pyridin-2-yl) arylsulfonamide, 22)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29866(N-(Pyridin-2-yl) arylsulfonamide, 28)
Affinity DataKi:  4.80nM ΔG°:  -47.0kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29858(N-(Pyridin-2-yl) arylsulfonamide, 20)
Affinity DataKi:  5.80nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29861(N-(Pyridin-2-yl) arylsulfonamide, 23)
Affinity DataKi:  6.60nM ΔG°:  -46.2kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29865(N-(Pyridin-2-yl) arylsulfonamide, 27)
Affinity DataKi:  9.80nM ΔG°:  -45.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29857(N-(Pyridin-2-yl) arylsulfonamide, 19)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29856(N-(Pyridin-2-yl) arylsulfonamide, 18)
Affinity DataKi:  48nM ΔG°:  -41.4kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Affinity DataKi:  62nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29859(N-(Pyridin-2-yl) arylsulfonamide, 21)
Affinity DataKi:  62nM ΔG°:  -40.7kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29854(N-(Pyridin-2-yl) arylsulfonamide, 16)
Affinity DataKi:  84nM ΔG°:  -40.0kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29850(N-(Pyridin-2-yl) arylsulfonamide, 12)
Affinity DataKi:  108nM ΔG°:  -39.4kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29849(N-(Pyridin-2-yl) arylsulfonamide, 11)
Affinity DataKi:  169nM ΔG°:  -38.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29843(N-(Pyridin-2-yl) arylsulfonamide, 3)
Affinity DataKi:  169nM ΔG°:  -38.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29841(N-(Pyridin-2-yl) arylsulfonamide, 1)
Affinity DataKi:  287nM ΔG°:  -37.0kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073830((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073822((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073824((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  45nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073833((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073831((4-Benzyl-benzyl)-[3-cyclobutyl-2-((R)-2,2-dimethy...)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073831((4-Benzyl-benzyl)-[3-cyclobutyl-2-((R)-2,2-dimethy...)
Affinity DataIC50:  180nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073833((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073837((4-Benzyl-benzyl)-[3-cyclopropyl-2-((R)-2,2-dimeth...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073846((4-Benzyl-benzyl)-{2-[(R)-2-(4-hydroxy-phenyl)-1-m...)
Affinity DataIC50:  270nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073828(Benzyl-[2-((R)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM17807(benzimidazole-urea, 34 | methyl N-(6-{[4-({[2-fluo...)
Affinity DataIC50:  340nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073830((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  690nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073834((4-Benzoyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylca...)
Affinity DataIC50:  750nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073837((4-Benzyl-benzyl)-[3-cyclopropyl-2-((R)-2,2-dimeth...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073830((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073841((4-Benzyl-benzyl)-[3-cyclohexyl-2-((R)-2,2-dimethy...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073824((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073829((4-Benzenesulfonyl-benzyl)-{2-[(R)-2-(4-hydroxy-ph...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073841((4-Benzyl-benzyl)-[3-cyclohexyl-2-((R)-2,2-dimethy...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073827((4-Cyclohexylmethyl-benzyl)-{2-[(R)-2-(4-hydroxy-p...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073826((4-Benzyl-benzyl)-[4-cyclohexyl-2-((R)-2,2-dimethy...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073842((4-Benzylcarbamoyl-benzyl)-{2-[(R)-2-(4-methoxy-ph...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073835(Biphenyl-4-ylmethyl-{2-[(R)-2-(4-hydroxy-phenyl)-1...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073838((4-Benzyl-benzyl)-[4-methyl-2-((R)-1-methylcarbamo...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073828(Benzyl-[2-((R)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073832(CHEMBL25347 | {2-[(R)-2-(4-Hydroxy-phenyl)-1-methy...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073836((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073836((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073821(CHEMBL284876 | {2-[(R)-2-(4-Hydroxy-phenyl)-1-meth...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073825(Biphenyl-3-ylmethyl-{2-[(R)-2-(4-hydroxy-phenyl)-1...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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