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Found 408 with Last Name = 'pelcman' and Initial = 'b'
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  0.230nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092669(CHEMBL129420 | N,N-Diethyl-4-(piperazin-1-yl-quino...)
Affinity DataIC50:  0.510nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501863(US11028067, Example 4)
Affinity DataIC50:  0.854nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124348(US8759537, 179)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124282(US8759537, 19)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124281(US8759537, 18)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124280(US8759537, 17)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109578(CHEMBL3604156)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124334(US8759537, 72)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124342(US8759537, 80)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124344(US8759537, 82)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124345(US8759537, 85)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124346(US8759537, 177)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124347(US8759537, 178)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124286(US8759537, 23)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522169(US11161815, Example 25)
Affinity DataIC50:  1.03nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092664(CHEMBL126819 | N,N-Diethyl-4-(piperazin-1-yl-quino...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092676(4-[(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yl)-pipe...)
Affinity DataIC50:  1.20nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522162(US11161815, Example 18)
Affinity DataIC50:  1.52nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124330(US8759537, 67)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124327(US8759537, 64)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124332(US8759537, 69)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124335(US8759537, 73)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124337(US8759537, 75)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124339(US8759537, 77)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124340(US8759537, 78)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124341(US8759537, 79)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124349(US8759537, 180)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124331(US8759537, 68)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124325(US8759537, 62)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50109729(CHEMBL3604185)
Affinity DataIC50:  2nMAssay Description:Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124265(US8759537, 1)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124266(US8759537, 2)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124269(US8759537, 5)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124270(US8759537, 6)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124271(US8759537, 7)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124285(US8759537, 22)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124288(US8759537, 25)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124289(US8759537, 26)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092680(CHEMBL125734 | N,N-Diethyl-4-(naphthalen-1-yl-pipe...)
Affinity DataIC50:  2.40nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124294(US8759537, 31)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124323(US8759537, 60)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124338(US8759537, 76)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124343(US8759537, 81)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124272(US8759537, 8)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124277(US8759537, 13)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124278(US8759537, 15)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM124283(US8759537, 20)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 ul of recombinant human mPGES-1 (0.5 ug protein/wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
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