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Found 519 with Last Name = 'persico' and Initial = 'm'
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271367(CHEMBL489454 | N-Methyl-N-(1,2,3,4-tetrahydroacrid...)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
Universit£

Curated by ChEMBL
LigandPNGBDBM50271556(CHEMBL525622 | N,N,N-trimethyl-3-(2,2,2-trifluoroa...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8965(CHEMBL338755 | Tacrine Dimer 4a | methylbis[3-(1,2...)
Affinity DataKi:  0.0600nM ΔG°:  -58.3kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
Universit£

Curated by ChEMBL
LigandPNGBDBM50149201(3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYD...)
Affinity DataKi:  0.0770nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271469(CHEMBL507174 | N-Allyl-N-(1,2,3,4-tetrahydroacridi...)
Affinity DataKi:  0.0850nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8977(CHEMBL175949 | N-[3-(1,2,3,4-Tetrahydroacridin-9-y...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271470(CHEMBL499224 | N-(2-Hydroxyethyl)-N-(1,2,3,4-tetra...)
Affinity DataKi:  0.119nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
Universit£

Curated by ChEMBL
LigandPNGBDBM50369748(CHEMBL208599)
Affinity DataKi:  0.130nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271471(1,4-bis[3-(1,2,3,4-Tetrahydroacridin-9-yl)aminopro...)
Affinity DataKi:  0.136nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271468(CHEMBL490060 | N-Ethyl-N-(1,2,3,4-tetrahydroacridi...)
Affinity DataKi:  0.162nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271325(CHEMBL451277 | N-{4-[(1,2,3,4-Tetrahydroacridin-9-...)
Affinity DataKi:  0.223nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8975(CHEMBL179192 | N-[3-(1,2,3,4-Tetrahydroacridin-9-y...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271323(CHEMBL501587 | N-{4-[(1,2,3, 4-Tetrahydroacridin-9...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50149201(3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYD...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity to mouse AChEMore data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271468(CHEMBL490060 | N-Ethyl-N-(1,2,3,4-tetrahydroacridi...)
Affinity DataKi:  0.435nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377920(CHEMBL540657)
Affinity DataKi:  0.460nMAssay Description:Inhibition of mouse BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8965(CHEMBL338755 | Tacrine Dimer 4a | methylbis[3-(1,2...)
Affinity DataKi:  0.540nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8968(2-{bis[3-(1,2,3,4-tetrahydroacridin-9-ylamino)prop...)
Affinity DataKi:  0.650nM ΔG°:  -52.4kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50369748(CHEMBL208599)
Affinity DataKi:  0.670nMAssay Description:Binding affinity to human AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8976(CHEMBL175555 | N-Methyl-N-(1,2,3,4-tetrahydroacrid...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50081973(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxal...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]zacopride from 5HT3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
Universit£

Curated by ChEMBL
LigandPNGBDBM50377920(CHEMBL540657)
Affinity DataKi:  0.720nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50149201(3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYD...)
Affinity DataKi:  0.720nMAssay Description:Inhibition of mouse BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271325(CHEMBL451277 | N-{4-[(1,2,3,4-Tetrahydroacridin-9-...)
Affinity DataKi:  0.725nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8977(CHEMBL175949 | N-[3-(1,2,3,4-Tetrahydroacridin-9-y...)
Affinity DataKi:  0.740nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8967(N,N-Bis[3-[(1,2,3,4-tetrahydroacridin-9-yl)amino]p...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271473(2,6-bis{[(1,2,3,4-Tetrahydroacridin-9-yl)amino]eth...)
Affinity DataKi:  0.768nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271324(CHEMBL482512 | N-(1,2,3,4-Tetrahydroacridin-9-yl)-...)
Affinity DataKi:  0.779nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Universita Di Siena

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50081969(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]zacopride from 5HT3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
Universit£

Curated by ChEMBL
LigandPNGBDBM10439((5S)-5-[(10-{[(5S)-2-oxo-1,2,5,6,7,8-hexahydroquin...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50258431(CHEMBL523716 | [4-(7-Fluoropyrrolo[1,2-a]quinoxali...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50060688(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271367(CHEMBL489454 | N-Methyl-N-(1,2,3,4-tetrahydroacrid...)
Affinity DataKi:  0.819nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271472(1,3-bis{[(1,2,3,4-Tetrahydroacridin-9-yl)amino]eth...)
Affinity DataKi:  0.924nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8966(N,N-Bis[3-[(1,2,3,4-tetrahydroacridin-9-yl)amino]p...)
Affinity DataKi:  0.940nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universita Di Siena

Curated by ChEMBL
LigandPNGBDBM50322374(1,6-bis(4-phenylpiperazin-1-yl)hexane | CHEMBL1172...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Universita Di Siena

Curated by ChEMBL
LigandPNGBDBM50322373(1-(3-chlorophenyl)-4-(6-(4-(3-methoxyphenyl)pipera...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8OH-DPAT from 5HT1A receptor in rat CRL:CD(SD)BR-COBS hippocampus by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271470(CHEMBL499224 | N-(2-Hydroxyethyl)-N-(1,2,3,4-tetra...)
Affinity DataKi:  1.19nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50258495((R)-2-Amino-3-[4-(7-fluoropyrrolo[1,2-a]quinoxalin...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Universit£

Curated by ChEMBL
LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of fetal bovine serum AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Universita Di Siena

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampusMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8967(N,N-Bis[3-[(1,2,3,4-tetrahydroacridin-9-yl)amino]p...)
Affinity DataKi:  1.60nM ΔG°:  -50.2kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271517(1,4-bis{[(1,2,3,4-Tetrahydroacridin-9-yl)amino]eth...)
Affinity DataKi:  1.63nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  1.65nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271472(1,3-bis{[(1,2,3,4-Tetrahydroacridin-9-yl)amino]eth...)
Affinity DataKi:  1.72nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50271473(2,6-bis{[(1,2,3,4-Tetrahydroacridin-9-yl)amino]eth...)
Affinity DataKi:  1.87nMAssay Description:Inhibition of human recombinant BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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