BindingDB PrimarySearch

Found 67 with Last Name = 'piizzi' and Initial = 'g'

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469565(CHEMBL4082918)

IC50: 1nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469558(CHEMBL4061041)

IC50: 1.46nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520437(CHEMBL4562597)

IC50: 2.70nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50249583(CHEMBL4097399)

IC50: 3.13nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469562(CHEMBL4069725)

IC50: 3.56nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520427(CHEMBL4470066)

IC50: 3.70nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469559(CHEMBL4063087)

IC50: 4.15nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469555(CHEMBL4090716)

IC50: 4.19nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520433(CHEMBL4451234)

IC50: 5.30nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 5.60nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520435(CHEMBL4442382)

IC50: 6.30nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520430(CHEMBL4515125)

IC50: 6.90nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520431(CHEMBL4566380)

IC50: 7.80nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Rattus norvegicus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 11nMAssay Description:Inhibition of mTOR L1460P mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469560(CHEMBL4083624)

IC50: 12.5nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Rattus norvegicus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 14nMAssay Description:Inhibition of mTOR S2215Y mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469563(CHEMBL4079368)

IC50: 16.4nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Rattus norvegicus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 17nMAssay Description:Inhibition of mTOR S2215F mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Rattus norvegicus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 17nMAssay Description:Inhibition of mTOR in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot analysis (Rvb = 19...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469550(CHEMBL4070478)

IC50: 19.7nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine-protein kinase ATM(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 20nMAssay Description:Inhibition of ATM (unknown origin) assessed as reduction in CHK2 phosphorylation by cell based assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Rattus norvegicus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 22nMAssay Description:Inhibition of mTOR E2419K mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Rattus norvegicus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 24nMAssay Description:Inhibition of mTOR L2427P mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Rattus norvegicus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 37nMAssay Description:Inhibition of mTOR C1483Y mutant in rat primary cortical neuron assessed as reduction in PS6 phosphorylation incubated for 4 hrs by Western blot anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469557(CHEMBL4091408)

IC50: 37.5nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520426(CHEMBL4514031)

IC50: 38nMAssay Description:Inhibition of mTOR in mouse TSC1-/- MEF cells assessed as inhibition of S6 Ser240/244 phosphorylation incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469554(CHEMBL4061854)

IC50: 39nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520438(CHEMBL4460774)

IC50: 56nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469553(CHEMBL4102769)

IC50: 81.4nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520439(CHEMBL4468727)

IC50: 92nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469552(CHEMBL4072428)

IC50: 98nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469548(CHEMBL4073216)

IC50: 116nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520434(CHEMBL4522946)

IC50: 134nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 210nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469549(CHEMBL4092311)

IC50: 268nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520436(CHEMBL4435029)

IC50: 278nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520429(CHEMBL4574882)

IC50: 305nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469551(CHEMBL4064630)

IC50: 342nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469561(CHEMBL4065657)

IC50: 362nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 394nMAssay Description:Inhibition of ATR (unknown origin) assessed as reduction in CHK1 phosphorylation by cell based assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520432(CHEMBL4538499)

IC50: 603nMAssay Description:Inhibition of mTOR in mouse MEF cells harboring TSC1 deletion mutant assessed as reduction in PS6 phosphorylation incuabted for 2 hrs alexa fluor 594...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520426(CHEMBL4514031)

IC50: 800nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469556(CHEMBL4087085)

IC50: 899nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 1.29E+3nMAssay Description:Inhibition of DNAPK (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

UDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50469564(CHEMBL4100062)

IC50: 1.64E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa LpxC using UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate preincubated for 30 mins followed by sub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 1.70E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Cytochrome P450 2C9(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520426(CHEMBL4514031)

IC50: 1.98E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520428(CHEMBL4518369)

IC50: 2.20E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520426(CHEMBL4514031)

IC50: 6.60E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50520426(CHEMBL4514031)

IC50: 6.60E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Displayed 1 to 50 (of 67 total ) | Next | Last >>

Filter my 67 hits

Targets 23▿
- Serine/threonine-protein kinase mTOR 21
- UDP-3-O-acyl-N-acetylglucosamine deacetylase 19
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2
- Cytochrome P450 2C9 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Cytochrome P450 2D6 2
- Serine-protein kinase ATM 1
- Polyamine deacetylase HDAC10 1
- Histone deacetylase 8 1
- Histone deacetylase 9 1
- Histone deacetylase 6 1
- Histone deacetylase 7 1
- Histone deacetylase 4 1
- Histone deacetylase 5 1
- DNA-dependent protein kinase catalytic subunit 1
- Histone deacetylase 2 1
- Histone deacetylase 3 1
- Histone deacetylase 11 1
- Histone deacetylase 1 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1
- Serine/threonine-protein kinase ATR 1
Publications 2▿
- J Med Chem 63: 1068-1083 (2020) 37
- J Med Chem 60: 5002-5014 (2017) 30
Institutions 1▿
- Novartis Institutes For Biomedical Research 67
Affinity: 1 to 5.0E+4 nM▿
- IC50 67
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0