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Found 194 with Last Name = 'ponzi' and Initial = 's'
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human HDAC3 expressed in baculovirus infected insect cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50175036(CHEMBL3809599)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant human His-tagged HDAC1 expressed in insect cells preincubated for 10 mins followed by addition of FLUOR DE LYS as fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612447(CHEMBL5285293)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612445(CHEMBL5282110)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612450(CHEMBL5279520)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612452(CHEMBL5285418)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50406432(CHEMBL5288562)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50258549((S)-2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-(1-(5-(...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612453(CHEMBL5285433)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50608555(CHEMBL5269165)
Affinity DataIC50: <3.5nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50612445(CHEMBL5282110)
Affinity DataIC50: <3.5nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50612445(CHEMBL5282110)
Affinity DataIC50: <3.5nMAssay Description:Inhibition of human HDAC3 expressed in baculovirus infected insect cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50608555(CHEMBL5269165)
Affinity DataIC50: <3.5nMAssay Description:Inhibition of human HDAC3 expressed in baculovirus infected insect cells using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50608555(CHEMBL5269165)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50406430(CHEMBL5274747)
Affinity DataIC50:  4nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406429(CHEMBL5276842)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50406431(CHEMBL5278011)
Affinity DataIC50:  6nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612451(CHEMBL5273223)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612448(CHEMBL5268361)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612444(CHEMBL5285266)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50175039(CHEMBL3808639)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant his tagged HDAC3 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50612443(CHEMBL5283156)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant his tagged HDAC3 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50162108(3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHE...)
Affinity DataIC50:  26nMAssay Description:Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50612441(CHEMBL5268555)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant his tagged HDAC3 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50612446(CHEMBL5270878)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi)
Irbm

Curated by ChEMBL
LigandPNGBDBM50545214(CHEMBL4633298)
Affinity DataIC50:  41nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50612440(CHEMBL5276254)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant his tagged HDAC3 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50406376(CHEMBL5289332)
Affinity DataIC50:  47nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50162094(3-Cyclohexyl-2-phenyl-1H-indole-6-carboxylic acid ...)
Affinity DataIC50:  48nMAssay Description:Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi)
Irbm

Curated by ChEMBL
LigandPNGBDBM50545214(CHEMBL4633298)
Affinity DataIC50:  52nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi)
Irbm

Curated by ChEMBL
LigandPNGBDBM50545214(CHEMBL4633298)
Affinity DataIC50:  52nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi)
Irbm

Curated by ChEMBL
LigandPNGBDBM50545219(CHEMBL4646274)
Affinity DataIC50:  53nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50187149(6-cyclohexyl-4-(2-(dimethylamino)-2-oxoethyl)-5-ph...)
Affinity DataIC50:  58nMAssay Description:Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50162102(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-phenyl-1H...)
Affinity DataIC50:  59nMAssay Description:Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50406428(CHEMBL5289545)
Affinity DataIC50:  64nMAssay Description:In vitro inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50187141(6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-ca...)
Affinity DataIC50:  66nMAssay Description:Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50:  71nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
LigandPNGBDBM50406374(CHEMBL5266583)
Affinity DataIC50:  74nMAssay Description:Inhibition of dihydrofolate reductase in Candida albicans (in vitro).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi)
Irbm

Curated by ChEMBL
LigandPNGBDBM50545216(CHEMBL4638031)
Affinity DataIC50:  77nMAssay Description:Inhibition of Trypanosoma cruzi CYP51More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50187135(1-cyclohexyl-2-phenylindolizine-6-carboxylic acid ...)
Affinity DataIC50:  94nMAssay Description:Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50187140(4-cyclohexyl-5-phenyl-6H-thieno[2,3-b]pyrrole-2-ca...)
Affinity DataIC50:  120nMAssay Description:Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM392347(US10301278, Example 30)
Affinity DataIC50:  142nMAssay Description:In vitro inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50187139(3-cyclohexyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine-6-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50612442(CHEMBL5271865)
Affinity DataIC50:  162nMAssay Description:Inhibition of human recombinant his tagged HDAC3 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM50612449(CHEMBL5271471)
Affinity DataIC50:  177nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50612445(CHEMBL5282110)
Affinity DataIC50:  190nMAssay Description:Inhibition of hERG potassium channel incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50175039(CHEMBL3808639)
Affinity DataIC50:  198nMAssay Description:Inhibition of human recombinant his tagged HDAC1 expressed in baculovirus expression system using FLUOR DE LYS-SIRT1 as fluorogenic substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50175039(CHEMBL3808639)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human His-tagged HDAC1 expressed in insect cells preincubated for 10 mins followed by addition of FLUOR DE LYS as fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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