Affinity DataKi: 0.00480nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
Affinity DataKi: 0.00990nM ΔG°: -62.2kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
Affinity DataKi: 0.0316nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0400nM ΔG°: -58.8kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
Affinity DataKi: 0.0410nM ΔG°: -58.7kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataKi: 0.0500nMAssay Description:Affinity at alpha4-beta2 nACh receptors in rat brain (minus cerebellum) homogenates.More data for this Ligand-Target Pair
Affinity DataKi: 0.0501nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0501nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0525nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.0575nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.0630nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
Affinity DataKi: 0.0631nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0631nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0661nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.0676nMAssay Description:Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0676nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0680nM ΔG°: -57.4kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
Affinity DataKi: 0.0780nMAssay Description:Compound was tested for inhibition of squalene synthase in rat liver.More data for this Ligand-Target Pair
Affinity DataKi: 0.0891nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.0977nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.110nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.126nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.135nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M3 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nM ΔG°: -55.7kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
Affinity DataKi: 0.141nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M4 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
Affinity DataKi: 0.160nM ΔG°: -55.3kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Apparent inhibitory constant against human cathepsin KMore data for this Ligand-Target Pair
Affinity DataKi: 0.178nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.178nMAssay Description:Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nM ΔG°: -54.9kJ/mole IC50: 0.5nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.209nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.209nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1A expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1A expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1B expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Apparent inhibitory constant against human cathepsin SMore data for this Ligand-Target Pair
Affinity DataKi: 0.280nM ΔG°: -54.0kJ/mole IC50: 0.300nMpH: 7.5 T: 2°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [125I][MePhe]NKB from human NK3 receptor expressed in CHO cells membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.302nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic receptor M1 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation countin...More data for this Ligand-Target Pair
Affinity DataKi: 0.309nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor expressed in human HeLa cell membranes after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cell membranes after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.316nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.316nMAssay Description:Displacement of [3H]prazosin from cloned human ADRA1A expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.324nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair