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Found 105 with Last Name = 'rapeport' and Initial = 'g'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156158(CHEMBL3781244)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein M2-1(Human respiratory syncytial virus A (strain A2))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50256886(CHEMBL4091425)
Affinity DataIC50:  2nMAssay Description:Inhibition of Respiratory syncytial virus A2 M2-1 by luciferase reporter-based RSV minigenome assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156160(CHEMBL3780667)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156162(CHEMBL3781245)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM206344(US9260410, 2)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNucleoprotein(Human respiratory syncytial virus A (strain A2))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50256886(CHEMBL4091425)
Affinity DataIC50:  2nMAssay Description:Inhibition of Respiratory syncytial virus A2 protein N by luciferase reporter-based RSV minigenome assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoprotein(Human respiratory syncytial virus A (strain A2))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50256886(CHEMBL4091425)
Affinity DataIC50:  2nMAssay Description:Inhibition of Respiratory syncytial virus A2 protein P by luciferase reporter-based RSV minigenome assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM206344(US9260410, 2)
Affinity DataIC50:  2.5nMAssay Description:The enzyme inhibitory activities of compounds disclosed herein were determined by fluorescence resonance energy transfer (FRET) using synthetic pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156129(CHEMBL3782036)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156135(CHEMBL3781413)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156133(CHEMBL3782009)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156144(CHEMBL3781687)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM206345(US9260410, 3)
Affinity DataIC50:  6.70nMAssay Description:The enzyme inhibitory activities of compounds disclosed herein were determined by fluorescence resonance energy transfer (FRET) using synthetic pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156128(CHEMBL3780488)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156163(CHEMBL3780832)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156157(CHEMBL3781473)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156127(CHEMBL3781430)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156126(CHEMBL3780111)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM142598(US10238658, Example Reference | US10813932, Refere...)
Affinity DataIC50:  12nMT: 2°CAssay Description:The enzyme inhibitory activity of compound was determined by FRET using synthetic peptides labelled with both donor and acceptor fluorophores (Z-LY...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  12nMT: 2°CAssay Description:The enzyme inhibitory activity of compound was determined by FRET using synthetic peptides labelled with both donor and acceptor fluorophores (Z-LY...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  12nMAssay Description:The enzyme inhibitory activities of compounds disclosed herein were determined by fluorescence resonance energy transfer (FRET) using synthetic pepti...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM14860(1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156136(CHEMBL3781532)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM14840(1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156137(CHEMBL3780714)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM206345(US9260410, 3)
Affinity DataIC50: <18nMAssay Description:The enzyme inhibitory activities of compounds disclosed herein were determined by fluorescence resonance energy transfer (FRET) using synthetic pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM14862(1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156151(CHEMBL3780519)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156132(CHEMBL3780629)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156136(CHEMBL3781532)
Affinity DataIC50:  26nMAssay Description:Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156144(CHEMBL3781687)
Affinity DataIC50:  26nMAssay Description:Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156164(CHEMBL3780386)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156130(CHEMBL3780154)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156131(CHEMBL3780089)
Affinity DataIC50:  33nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156169(CHEMBL3781999)
Affinity DataIC50:  38nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration required for in vitro binding affinity to Nicotinic acetylcholine receptor alpha3-beta2 expressed on cell line sf 9 by using...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM206344(US9260410, 2)
Affinity DataIC50:  51nMAssay Description:Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM142597(US8933228, Ref 1)
Affinity DataIC50:  52nMAssay Description:Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156165(CHEMBL3781982)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156163(CHEMBL3780832)
Affinity DataIC50:  55nMAssay Description:Inhibitory concentration required for in vitro binding affinity to Nicotinic acetylcholine receptor alpha3-beta2 expressed on cell line Sf 9 by using...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156125(CHEMBL3781587)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156127(CHEMBL3781430)
Affinity DataIC50:  82nMAssay Description:Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  102nMAssay Description:Inhibition of human recombinant p38 gamma assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156163(CHEMBL3780832)
Affinity DataIC50:  110nMAssay Description:Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156134(CHEMBL3780410)
Affinity DataIC50:  123nMAssay Description:Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM206345(US9260410, 3)
Affinity DataIC50:  146nMAssay Description:The enzyme inhibitory activities of compounds disclosed herein were determined by fluorescence resonance energy transfer (FRET) using synthetic pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156162(CHEMBL3781245)
Affinity DataIC50:  148nMAssay Description:Inhibition of human recombinant p38 gamma assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sygnature Discovery

Curated by ChEMBL
LigandPNGBDBM50156130(CHEMBL3780154)
Affinity DataIC50:  164nMAssay Description:Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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