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Found 61 with Last Name = 'sadeghpour' and Initial = 'bm'
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50061907((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  900nMAssay Description:Ability to inhibit kynurenine-3-hydroxylase was determined in a competitive inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynureninase(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50040567(CHEMBL158499 | ortho-nitrobenzoyl)alanine)
Affinity DataIC50:  1.00E+5nMAssay Description:Ability to inhibit kynureninase was determined in a competitive inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynureninase(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50061907((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  1.00E+5nMAssay Description:Ability to inhibit kynureninase was determined in a competitive inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50040568(CHEMBL157866 | para-nitrobenzoyl)alanine)
Affinity DataIC50:  3.00E+5nMAssay Description:Ability to inhibit kynurenine-3-hydroxylase was determined in a competitive inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynureninase(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50040570(CHEMBL160527 | NICOTINOYLALANINENAL | nicotinoylal...)
Affinity DataIC50:  8.00E+5nMAssay Description:Ability to inhibit kynureninase was determined in a competitive inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50040570(CHEMBL160527 | NICOTINOYLALANINENAL | nicotinoylal...)
Affinity DataIC50:  9.00E+5nMAssay Description:Ability to inhibit kynurenine-3-hydroxylase was determined in a competitive inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynureninase(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50040568(CHEMBL157866 | para-nitrobenzoyl)alanine)
Affinity DataIC50:  9.00E+5nMAssay Description:Ability to inhibit kynureninase was determined in a competitive inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50040567(CHEMBL158499 | ortho-nitrobenzoyl)alanine)
Affinity DataIC50:  2.00E+6nMAssay Description:Ability to inhibit kynurenine-3-hydroxylase was determined in a competitive inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21682((2R,4R)-2-methyl-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15...)
Affinity DataEC50: >5.19E+4nMpH: 7.2 T: 2°CAssay Description:For transient transfection assays to analyze TGR5 activity, Chinese hamster ovary (CHO) cells were transfected with hTGR5 expression plasmid, cAMP-re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  1.30E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21675((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Affinity DataEC50:  361nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21676((2S,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50: >1.00E+5nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21677((2R,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50:  1.05E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21678((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-5,9...)
Affinity DataEC50:  1.16E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21679((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-e...)
Affinity DataEC50:  1.18E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50002612(CHEMBL3138403)
Affinity DataEC50:  2.72E+3nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21675((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Affinity DataEC50:  98nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50002614(CHEMBL3138092)
Affinity DataEC50:  590nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50002611(CHEMBL3138044)
Affinity DataEC50:  9.68E+3nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151410(CHEMBL189237 | Sulfuric acid mono-[(R)-4-((3R,7R,1...)
Affinity DataEC50:  5.99E+3nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151411((R)-2-[(R)-1-((3R,7R,10S,13R)-7-Hydroxy-3-(S)-hydr...)
Affinity DataEC50:  4.27E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151409((R)-2-[(R)-1-((3R,7R,10S,13R)-7-Hydroxy-3-(R)-hydr...)
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151412((R)-2-[(S)-1-((3R,7R,10S,13R)-7-Hydroxy-3-(R)-hydr...)
Affinity DataEC50:  2.43E+3nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151413((R)-4-((3R,6R,7R,10S,13R)-3,7-Dihydroxy-6,10,13-tr...)
Affinity DataEC50:  1.56E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151414((R)-4-((3R,6R,7S,10R,13R)-6-Fluoro-3,7-dihydroxy-1...)
Affinity DataEC50:  1.51E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151417(4-((4R,5S,9R,14R)-7-Hydroxy-3-(R)-hydroxy-10,13-di...)
Affinity DataEC50:  4.55E+3nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151415((3S,5R)-4-((3R,7R,10S,13R)-3,7-Dihydroxy-10,13-dim...)
Affinity DataEC50:  3.32E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151418((R)-4-((3R,6R,7S,10R,13R)-3,6,7-Trihydroxy-10,13-d...)
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151419((3R,7R,10S,13R)-17-((R)-3-Amino-1-methyl-propyl)-1...)
Affinity DataEC50:  9.68E+3nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151416(CHEMBL424989 | [(R)-3-((3R,7R,10S,13R)-3,7-Dihydro...)
Affinity DataEC50:  2.72E+3nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151420((R)-4-((3R,6R,7R,10S,13R)-3,7-Dihydroxy-10,13-dime...)
Affinity DataEC50:  540nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151421(3-((E)-2-{4-[3-(2,6-Dichloro-phenyl)-5-isopropyl-i...)
Affinity DataEC50:  30nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  8.66E+3nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151423(2-((4R,5S,9R,14S)-7-Hydroxy-3-(S)-hydroxy-10,13-di...)
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151422((R)-4-((3R,6S,7S,10R,13R)-6-Fluoro-3,7-dihydroxy-1...)
Affinity DataEC50:  1.21E+3nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151425((R)-4-[(3R,6R,7R,10S,13R)-3,7-Dihydroxy-6-(2-hydro...)
Affinity DataEC50:  6.12E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151424((1R,3R)-4-((3R,7R,10S,13R)-3,7-Dihydroxy-10,13-dim...)
Affinity DataEC50:  1.02E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151427((R)-4-((3R,6R,7R,10S,13R)-6-Allyl-3,7-dihydroxy-10...)
Affinity DataEC50:  480nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151428(2-[(R)-3-((3R,7R,10S,13R)-3,7-Dihydroxy-10,13-dime...)
Affinity DataEC50:  1.22E+3nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151429((1S,3R)-4-((3R,7R,10S,13R)-3,7-Dihydroxy-10,13-dim...)
Affinity DataEC50:  1.32E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151431((R)-2-[(S)-1-((3R,7R,10S,13R)-7-Hydroxy-3-(S)-hydr...)
Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50151430((R)-4-((3R,6R,7S,10R,13R)-3,7-Dihydroxy-6-methoxy-...)
Affinity DataEC50:  1.47E+4nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50117091((R)-4-((3R,6R,7R,10S,13R)-3,7-Dihydroxy-6,10,13-tr...)
Affinity DataEC50:  750nMAssay Description:Binding affinity for human Farnesoid X receptor in FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50190590(23-N-(carbocyclohexyloxy)-3alpha,7alpha-dihydroxy-...)
Affinity DataEC50:  1.14E+3nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50190591(23-N-(carboisopropyloxy)-3alpha,7alpha-dihydroxy-2...)
Affinity DataEC50:  2.50E+3nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  8.66E+3nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50190592(23-N-(carbo-p-methoxybenzyloxy)-3alpha,7alpha-dihy...)
Affinity DataEC50:  1.48E+3nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50190593(23-N-(carbobenzyloxy)-3alpha,7alpha-dihydroxy-24-n...)
Affinity DataEC50:  790nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50190594(23-N-(carbo-2'-adamantyloxy)-3alpha,7alpha-dihydro...)
Affinity DataEC50:  600nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
University Di Perugia

LigandPNGBDBM50190595(23-N-(carbo-p-carboxybenzyloxy)-3alpha,7alpha-dihy...)
Affinity DataEC50:  7.11E+3nMAssay Description:Binding affinity to FXR assessed as ligand-dependent SRC1 recruitment by FRET based co-activator assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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