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Found 152 with Last Name = 'sakami' and Initial = 's'
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  7.44nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262557((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  7.99nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  12.7nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50244419((4bS,8R,8aS,16bR)-7-(cyclopropylmethyl)-5,6,7,8,8a...)
Affinity DataKi:  15.1nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262557((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  23.2nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  27nMAssay Description:Binding affinity to guinea pig mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM21864((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Affinity DataKi:  30.4nMAssay Description:Binding affinity to guinea pig kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261726((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261791((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50244419((4bS,8R,8aS,16bR)-7-(cyclopropylmethyl)-5,6,7,8,8a...)
Affinity DataKi:  60.6nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261726((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  113nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261791((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262499((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  2.51E+3nMAssay Description:Binding affinity to guinea pig mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50245093((5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  3.29E+3nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261727((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  3.34E+3nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50245093((5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi: >3.67E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262556((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi: >3.67E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50261727((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi: >3.67E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262499((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  3.91E+3nMAssay Description:Binding affinity to guinea pig kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50262556((5R,9R,13S,14S)-17-Cyclopropylmethyl-6,7-didehydro...)
Affinity DataKi:  4.65E+3nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in Hartley guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276045((R)-3-Amino-4-(5-chloro-2-fluoro-phenyl)-N-{4-[6-(...)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276047((R)-3-Amino-N-{4-[6-(2-morpholin-4-yl-ethoxy)-benz...)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276001((R)-3-Amino-N-{4-[6-(2-methoxy-ethoxy)-benzothiazo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276046((R)-3-amino-4-(5-chloro-2-fluorophenyl)-N-(4-(6-(2...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50275954((R)-3-Amino-N-[4-(6-methoxy-benzothiazol-2-yl)-1,1...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50275955((R)-3-Amino-N-[4-(5-methoxy-benzothiazol-2-yl)-1,1...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430145(CHEMBL2338266)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276044((3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430135(CHEMBL2338251)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430139(CHEMBL2338247)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430136(CHEMBL2338250)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50401518(CHEMBL2206469)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of DPP4 in human Caco2 cell extracts using Ala-Pro-AFC as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430140(CHEMBL2338246)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430132(CHEMBL2338254)
Affinity DataIC50:  8nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430141(CHEMBL2338245)
Affinity DataIC50:  8nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430147(CHEMBL2338264)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430134(CHEMBL2338252)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430147(CHEMBL2338264)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430142(CHEMBL2338244)
Affinity DataIC50:  10nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430138(CHEMBL2338248)
Affinity DataIC50:  11nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430137(CHEMBL2338249)
Affinity DataIC50:  11nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430148(CHEMBL2338263)
Affinity DataIC50:  12nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430148(CHEMBL2338263)
Affinity DataIC50:  12nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50401519(CHEMBL2203319)
Affinity DataIC50:  12nMAssay Description:Inhibition of DPP4 in human Caco2 cell extracts using Ala-Pro-AFC as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50275905((R)-3-Amino-4-(2-fluoro-phenyl)-N-[4-(6-methoxy-be...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430140(CHEMBL2338246)
Affinity DataIC50:  13nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50275904((R)-3-Amino-N-(4-benzothiazol-2-yl-1,1-dioxo-hexah...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50401517(CHEMBL2206475)
Affinity DataIC50:  16nMAssay Description:Inhibition of DPP4 in human Caco2 cell extracts using Ala-Pro-AFC as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430134(CHEMBL2338252)
Affinity DataIC50:  17nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430138(CHEMBL2338248)
Affinity DataIC50:  18nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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