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Found 564 with Last Name = 'sakurai' and Initial = 'k'
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127501(3-(4-Carbamimidoyl-2-{2-[4-(pyrrolidine-1-carbonyl...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127492(4-[5-Carbamimidoyl-2-(2-carboxy-2-oxo-ethyl)-pheno...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127502(4-[5-Carbamimidoyl-2-(2-carboxy-2-oxo-ethyl)-pheno...)
Affinity DataKi:  18nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127495(3-[4-Carbamimidoyl-2-(2-{4-[1-(1-imino-ethyl)-pipe...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127504(CHEMBL55770 | N-[2-(3-Carbamimidoyl-phenoxy)-ethyl...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127494(3-(4-Carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1...)
Affinity DataKi:  21nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127498(3-{4-Carbamimidoyl-2-[2-(4-carbamimidoyl-benzoylam...)
Affinity DataKi:  26nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127503(3-(4-Carbamimidoyl-benzoylamino)-4-(3-carbamimidoy...)
Affinity DataKi:  28nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127493(3-(4-Carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1...)
Affinity DataKi:  43nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127496(CHEMBL51796 | N-[2-(3-Carbamimidoyl-phenoxy)-ethyl...)
Affinity DataKi:  170nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127506(3-(4-Carbamimidoyl-benzoylamino)-4-(3-carbamimidoy...)
Affinity DataKi:  170nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127497(4-Carbamimidoyl-N-[2-(3-carbamimidoyl-phenoxy)-eth...)
Affinity DataKi:  220nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127500(3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxyl...)
Affinity DataKi:  290nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127499(3-[4-Carbamimidoyl-2-(2-{4-[1-(1-imino-ethyl)-pipe...)
Affinity DataKi:  330nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127505(CHEMBL55364 | N-[2-(3-Carbamimidoyl-phenoxy)-ethyl...)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibitory activity against Coagulation factor X (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127501(3-(4-Carbamimidoyl-2-{2-[4-(pyrrolidine-1-carbonyl...)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127498(3-{4-Carbamimidoyl-2-[2-(4-carbamimidoyl-benzoylam...)
Affinity DataKi:  3.80E+4nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127495(3-[4-Carbamimidoyl-2-(2-{4-[1-(1-imino-ethyl)-pipe...)
Affinity DataKi:  5.30E+4nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127504(CHEMBL55770 | N-[2-(3-Carbamimidoyl-phenoxy)-ethyl...)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127494(3-(4-Carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127496(CHEMBL51796 | N-[2-(3-Carbamimidoyl-phenoxy)-ethyl...)
Affinity DataKi:  4.40E+5nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127492(4-[5-Carbamimidoyl-2-(2-carboxy-2-oxo-ethyl)-pheno...)
Affinity DataKi:  5.40E+5nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127502(4-[5-Carbamimidoyl-2-(2-carboxy-2-oxo-ethyl)-pheno...)
Affinity DataKi:  6.80E+5nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127497(4-Carbamimidoyl-N-[2-(3-carbamimidoyl-phenoxy)-eth...)
Affinity DataKi:  7.10E+5nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127505(CHEMBL55364 | N-[2-(3-Carbamimidoyl-phenoxy)-ethyl...)
Affinity DataKi:  8.00E+5nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127500(3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxyl...)
Affinity DataKi:  1.00E+6nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127493(3-(4-Carbamimidoyl-2-{2-[(3,4,5,6-tetrahydro-2H-[1...)
Affinity DataKi: >1.50E+6nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127503(3-(4-Carbamimidoyl-benzoylamino)-4-(3-carbamimidoy...)
Affinity DataKi: >1.50E+6nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127499(3-[4-Carbamimidoyl-2-(2-{4-[1-(1-imino-ethyl)-pipe...)
Affinity DataKi: >1.50E+6nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Ajinomoto

Curated by ChEMBL
LigandPNGBDBM50127506(3-(4-Carbamimidoyl-benzoylamino)-4-(3-carbamimidoy...)
Affinity DataKi: >1.50E+6nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM640486(US20230399319, Example 2-031)
Affinity DataIC50:  0nMAssay Description:The NLRP3 inflammasome inhibitory activity of test compounds were evaluated CM the basis of the inhibitory activity of the IL-1β, production in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493926(US10988462, Example 37)
Affinity DataIC50:  0.980nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493906(US10988462, Example 21)
Affinity DataIC50:  1.20nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493905(US10988462, Example 20)
Affinity DataIC50:  1.20nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493894(US10988462, Example 10)
Affinity DataIC50:  1.20nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493901(US10988462, Example 17)
Affinity DataIC50:  1.30nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493925(US10988462, Example 36)
Affinity DataIC50:  1.90nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493879(US10988462, Example 1)
Affinity DataIC50:  1.90nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493917(US10988462, Example 30)
Affinity DataIC50:  2.70nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493897(US10988462, Example 13)
Affinity DataIC50:  2.90nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273013(CHEMBL4129456)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TRPC6 expressed in HEK293 cells assessed as decrease in intracellular calcium level after 24 hrs by Fluo-4 dye-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493907(US10988462, Example 22)
Affinity DataIC50:  3.40nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493898(US10988462, Example 14)
Affinity DataIC50:  3.70nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493927(US10988462, Example 38)
Affinity DataIC50:  4nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493896(US10988462, Example 12)
Affinity DataIC50:  4.30nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493924(US10988462, Example 35)
Affinity DataIC50:  4.60nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493909(US10988462, Example 24)
Affinity DataIC50:  5.30nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493918(US10988462, Example 31)
Affinity DataIC50:  5.70nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493910(US10988462, Example 25)
Affinity DataIC50:  5.70nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Japan Tobacco

US Patent
LigandPNGBDBM493921(US10988462, Example 33)
Affinity DataIC50:  5.90nMAssay Description:Human SGLT1-stably-expressing cell lines were seeded at 5×104 cells/well on BioCoat™ Poly-D-Lysine 96 well plate with Lid (Becton, Dickinson and Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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