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Found 535 with Last Name = 'salvino' and Initial = 'jm'
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50090364(3-[2-Hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl...)
Affinity DataKi:  0.800nMAssay Description:In vitro inhibition of human recombinant Matrix metalloproteinase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058526((S)-3-{[(1S,9S)-9-(4-Carboxymethoxy-benzoylamino)-...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058530((S)-3-{[(1S,9S)-9-(2-Fluoro-benzoylamino)-6,10-dio...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361051(CHEMBL1935590)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to human NK3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361055(CHEMBL1935599)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361052(CHEMBL1935589 | CHEMBL1949758)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50006990(CHEMBL299499 | N-Adamantan-1-yl-N'-(4-iodo-phenyl)...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361058(CHEMBL1935594)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361052(CHEMBL1935589 | CHEMBL1949758)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240232(CHEMBL4080735)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-IPAG from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364326(CHEMBL1949930)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50090350(4-Ethyl-3-(4-methoxy-benzenesulfonyl)-octanoic aci...)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of human recombinant Matrix metalloproteinase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361053(CHEMBL1935601)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058528((S)-3-[((1S,9S)-9-Benzoylamino-6,10-dioxo-octahydr...)
Affinity DataKi:  5nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364323(CHEMBL1949928)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364323(CHEMBL1949928)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361050(CHEMBL1935592)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058527((S)-2-[(S)-2-((S)-2-Acetylamino-3-methyl-butyrylam...)
Affinity DataKi:  6nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361051(CHEMBL1935590)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]LSD from full length rat 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  7.40nMAssay Description:Binding affinity to human NK3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361049(CHEMBL1935593)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50090347(3-Cyclohexyl-N-hydroxy-3-(4-methoxy-benzenesulfony...)
Affinity DataKi:  8nMAssay Description:In vitro inhibition of human recombinant Matrix metalloproteinase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50090372(3-(4-Methoxy-benzenesulfonyl)-4-phenyl-pentanoic a...)
Affinity DataKi:  8nMAssay Description:In vitro inhibition of human recombinant Matrix metalloproteinase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361052(CHEMBL1935589 | CHEMBL1949758)
Affinity DataKi:  9.80nMAssay Description:Displacement of [3H]LSD from full length rat 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364311(CHEMBL1949763)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364312(CHEMBL1949764)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240230(CHEMBL4092687)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361055(CHEMBL1935599)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]LSD from full length rat 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50058529((S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  15nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364310(CHEMBL1949762)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50176519((S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  15nMAssay Description:Binding affinity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Sanofi Winthrop

Curated by ChEMBL
LigandPNGBDBM50286304((R)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  15nMAssay Description:Binding affinity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361057(CHEMBL1935597)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361053(CHEMBL1935601)
Affinity DataKi:  16.9nMAssay Description:Displacement of [3H]LSD from full length rat 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361053(CHEMBL1935601)
Affinity DataKi:  16.9nMAssay Description:Displacement of [3H]LSD from full length rat 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364316(CHEMBL1949768)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361061(CHEMBL1935595)
Affinity DataKi:  17.5nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361056(CHEMBL1935598)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(RAT)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361058(CHEMBL1935594)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]LSD from full length rat 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Euroscreen

Curated by ChEMBL
LigandPNGBDBM50341098((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-(3-fluor...)
Affinity DataKi:  20nMAssay Description:Displacement [3H]SB-222200 from of human recombinant NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074027(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)
Affinity DataKi:  20nMAssay Description:In vitro inhibition of human recombinant Matrix metalloproteinase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364311(CHEMBL1949763)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364311(CHEMBL1949763)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361062(CHEMBL1935591)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50361054(CHEMBL1935600)
Affinity DataKi:  22.3nMAssay Description:Displacement of [3H]LSD from full length human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364316(CHEMBL1949768)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50364316(CHEMBL1949768)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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