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Found 115 with Last Name = 'samuel' and Initial = 'r'
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541356(CHEMBL4632678)
Affinity DataIC50:  55nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 2 mins followed by substr...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541360(CHEMBL4640859)
Affinity DataIC50:  75nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 2 mins followed by substr...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541355(CHEMBL4644850)
Affinity DataIC50:  85nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 2 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541358(CHEMBL4642007)
Affinity DataIC50:  102nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 2 mins followed by substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50088504(A-84538 | ABBOTT-84538 | CHEBI:45409 | Norvir | Ri...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 20 mins in presence of NA...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541357(CHEMBL4648061)
Affinity DataIC50:  173nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 2 mins followed by substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541362(CHEMBL4642617)
Affinity DataIC50:  218nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 2 mins followed by substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541361(CHEMBL4639605)
Affinity DataIC50:  244nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 2 mins followed by substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342692(4-(1'-(5-chloropyrimidin-2-yl)-4,4'-bipiperidin-1-...)
Affinity DataIC50:  277nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541365(CHEMBL4644634)
Affinity DataIC50:  310nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 20 mins in presence of NA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541366(CHEMBL4645102)
Affinity DataIC50:  310nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 20 mins in presence of NA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541364(CHEMBL4635548)
Affinity DataIC50:  310nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 20 mins in presence of NA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541363(CHEMBL4639033)
Affinity DataIC50:  310nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 20 mins in presence of NA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541354(CHEMBL4638454)
Affinity DataIC50:  320nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 2 mins followed by substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541359(CHEMBL4644724)
Affinity DataIC50:  356nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 2 mins followed by substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50541354(CHEMBL4638454)
Affinity DataIC50:  430nMAssay Description:Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)coumarin as substrate preincubated for 20 mins in presence of NA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342698((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342696((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342696((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342693(2-methyl-6-(1'-(5-methylpyrimidin-2-yl)-4,4'-bipip...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342702(6-methyl-2-(2-((1S,2R)-2-(1-(5-methylpyrimidin-2-y...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human ERG by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342694(2-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342695(4-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342700(2-(4-((1R,2S)-2-(2-(4-(1H-1,2,3-triazol-1-yl)pheno...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human ERG by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342699(5-chloro-2-(4-((1R,2S)-2-(2-(5-(methylsulfonyl)pyr...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human ERG by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342703(CHEMBL1771104 | rac-4-(3-(2-(3-(1-(5-chloropyrimid...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342698((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342697((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342701(2-(4-((1R,2S)-2-(2-(5-(1H-1,2,3-triazol-1-yl)pyrid...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of human ERG by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342664(CHEMBL1770918 | tert-butyl 1'-(pyridin-3-yl)-4,4'-...)
Affinity DataEC50:  3.60E+3nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342665(CHEMBL1771064 | tert-butyl 1'-phenyl-4,4'-bipiperi...)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342666(CHEMBL1771066 | tert-butyl 1'-m-tolyl-4,4'-bipiper...)
Affinity DataEC50:  514nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342667(CHEMBL1771067 | tert-butyl 1'-p-tolyl-4,4'-bipiper...)
Affinity DataEC50:  338nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342668(CHEMBL1771068 | tert-butyl 1'-(4-(methylsulfonyl)p...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342669(CHEMBL1771069 | tert-butyl 1'-(3-(methylsulfonyl)p...)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342670(CHEMBL1771070 | tert-butyl 1'-(4-(methylsulfinyl)p...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342671(CHEMBL1771071 | tert-butyl 1'-(4-acetylphenyl)-4,4...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342672(CHEMBL1771072 | tert-butyl 1'-(4-(methylthio)pheny...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342673(CHEMBL1771073 | tert-butyl 1'-(4-carbamoylphenyl)-...)
Affinity DataEC50:  76nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342674(CHEMBL1771075 | tert-butyl 1'-(pyridin-2-yl)-4,4'-...)
Affinity DataEC50:  831nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342675(CHEMBL1771076 | tert-butyl 1'-(pyrimidin-4-yl)-4,4...)
Affinity DataEC50:  116nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342676(CHEMBL1771077 | tert-butyl 1'-(pyrimidin-2-yl)-4,4...)
Affinity DataEC50:  526nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342677(CHEMBL1771078 | tert-butyl 1'-(pyrazin-2-yl)-4,4'-...)
Affinity DataEC50:  103nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342678(CHEMBL1771079 | tert-butyl 1'-(2-cyanopyrimidin-4-...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342679(CHEMBL1771080 | tert-butyl 1'-(6-cyanopyrimidin-4-...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342680(CHEMBL1771081 | tert-butyl 1'-(2-cyano-6-methylpyr...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342681(CHEMBL1771082 | tert-butyl 1'-(6-cyano-2-methylpyr...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50342682(1-(4-(methylsulfonyl)phenyl)-1'-(pyridin-2-yl)-4,4...)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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