Found 125 with Last Name = 'sapkota' and Initial = 'k' 
Affinity DataIC50: 7.90nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
3D Structure (crystal)TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular ...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in glycine/glutamate-induced intracellular calci...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Negative allosteric modulation of human GluN2B receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
Affinity DataIC50: 143nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
Affinity DataIC50: 198nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Negative allosteric modulation of human GluN2A receptor expressed in HEK cells assessed as reduction in 3 uM glycine/glutamate-induced intracellular ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 446nMAssay Description:Negative allosteric modulation of human GluN1/GluN2A receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced chann...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2D(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2D(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2D(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 2.70E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2D(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 2.70E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2D(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 5.40E+3nMAssay Description:Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 7.10E+3nMAssay Description:Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 7.50E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2B expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 9.20E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2B expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 9.40E+3nMAssay Description:Negative allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 9.70E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.70E+3nMAssay Description:Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of human GluN2B receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of human GluN2C receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2D(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of human GluN2D receptor expressed in xenopus laevis oocytes assessed as reduction in 3 uM glycine-induced channel cur...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 1.11E+4nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2B expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+4nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2D(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Negative allosteric modulation of GluN2D receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Negative allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 1.78E+4nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.86E+4nMAssay Description:Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:Negative allosteric modulation of GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glycine-induced chann...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataIC50: 1.90E+4nMAssay Description:Negative allosteric modulation of GluN1a/GluN2A receptor (unknown origin) expressed in xenopus laevis oocytes assessed as reduction in glutamate/glyc...More data for this Ligand-Target Pair
