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Found 65 with Last Name = 'sasaki' and Initial = 'c'
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9989((2S,6S,15S)-6-hydroxy-2-(hydroxymethyl)-15-methylt...)
Affinity DataKi:  3.40nM ΔG°:  -50.3kJ/mole IC50:  31nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9997((2S,15S)-2-(hydroxymethyl)-15-methyltetracyclo[8.7...)
Affinity DataKi:  5.80nM ΔG°:  -48.9kJ/mole IC50:  49nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9994((2R,8R,15S)-8-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  6nM ΔG°:  -48.8kJ/mole IC50:  50nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9996((2R,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataKi:  6.80nM ΔG°:  -48.5kJ/mole IC50:  60nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9992((2R,8S,15S)-8-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  21nM ΔG°:  -45.6kJ/mole IC50:  190nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9987((2R,6S,15S)-6-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  25nM ΔG°:  -45.1kJ/mole IC50:  280nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9983((2R,6R,15S)-6-hydroxy-2,15-dimethyltetracyclo[8.7....)
Affinity DataKi:  58nM ΔG°:  -43.0kJ/mole IC50:  860nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9984((2R,6R,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0...)
Affinity DataKi:  60nM ΔG°:  -42.9kJ/mole IC50:  700nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9988((2R,6S,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0...)
Affinity DataKi:  90nM ΔG°:  -41.8kJ/mole IC50:  1.00E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9995((2S,8R,15S)-8-hydroxy-2-(hydroxymethyl)-15-methylt...)
Affinity DataKi:  110nM ΔG°:  -41.3kJ/mole IC50:  940nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9998((2R,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataKi:  120nM ΔG°:  -41.1kJ/mole IC50:  660nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9993((2S,8S,15S)-8-hydroxy-2-(hydroxymethyl)-15-methylt...)
Affinity DataKi:  250nM ΔG°:  -39.2kJ/mole IC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9985((2S,6R,15S)-6-hydroxy-2-(hydroxymethyl)-15-methylt...)
Affinity DataKi:  800nM ΔG°:  -36.2kJ/mole IC50:  6.80E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Tohoku Pharmaceutical University

LigandPNGBDBM9999((2S,15S)-2-(hydroxymethyl)-15-methyltetracyclo[8.7...)
Affinity DataKi:  1.00E+3nM ΔG°:  -35.6kJ/mole IC50:  6.90E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387831(CHEMBL2059114)
Affinity DataIC50:  19nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387832(CHEMBL2058906)
Affinity DataIC50:  22nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387833(CHEMBL2058665)
Affinity DataIC50:  22nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387835(CHEMBL2058900)
Affinity DataIC50:  23nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387834(CHEMBL2059115)
Affinity DataIC50:  23nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387836(CHEMBL2058905)
Affinity DataIC50:  24nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387837(CHEMBL2058664)
Affinity DataIC50:  24nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387838(CHEMBL2057522)
Affinity DataIC50:  26nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387828(CHEMBL2057523)
Affinity DataIC50:  26nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387839(CHEMBL2057527)
Affinity DataIC50:  27nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387840(CHEMBL2057518)
Affinity DataIC50:  28nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387841(CHEMBL2057791)
Affinity DataIC50:  30nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387842(CHEMBL2057792)
Affinity DataIC50:  30nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387843(CHEMBL2058910)
Affinity DataIC50:  31nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387844(CHEMBL2057790)
Affinity DataIC50:  31nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387845(CHEMBL2059117)
Affinity DataIC50:  33nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387847(CHEMBL2057788)
Affinity DataIC50:  37nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387846(CHEMBL2058663)
Affinity DataIC50:  37nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387848(CHEMBL2059120)
Affinity DataIC50:  38nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387849(CHEMBL2057787)
Affinity DataIC50:  38nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387850(CHEMBL2057786)
Affinity DataIC50:  39nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387851(CHEMBL2057524)
Affinity DataIC50:  40nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387852(CHEMBL2057517)
Affinity DataIC50:  41nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387853(CHEMBL2058901)
Affinity DataIC50:  42nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387854(CHEMBL2058903)
Affinity DataIC50:  44nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387855(CHEMBL2058904)
Affinity DataIC50:  52nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387856(CHEMBL2059119)
Affinity DataIC50:  53nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387829(CHEMBL2057528)
Affinity DataIC50:  55nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387857(CHEMBL2057521)
Affinity DataIC50:  60nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387858(CHEMBL2057794)
Affinity DataIC50:  69nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387859(CHEMBL2057520)
Affinity DataIC50:  79nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387860(CHEMBL2057514)
Affinity DataIC50:  84nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387861(CHEMBL2059116)
Affinity DataIC50:  90nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387862(CHEMBL2059123)
Affinity DataIC50:  92nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387863(CHEMBL2057789)
Affinity DataIC50:  97nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Infectious Diseases-Diagnostics

Curated by ChEMBL
LigandPNGBDBM50387864(CHEMBL2059126)
Affinity DataIC50:  110nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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