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Found 545 with Last Name = 'schaefer' and Initial = 'v'
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19386(2,4-diaminopyrimidine derivative, 8b | 6-[(benzylo...)
Affinity DataIC50:  0.200nM EC50:  5.80nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19387(2,4-diaminopyrimidine derivative, 8c | 6-[(benzylo...)
Affinity DataIC50:  0.300nM EC50:  7.20nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19387(2,4-diaminopyrimidine derivative, 8c | 6-[(benzylo...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181180(CHEMBL377514 | N-(3,5-dimethylbenzyl)-3-(5-(4-(4-(...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181184(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((3-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105186(4-(4-Trifluoromethyl-phenoxy)-thieno[2,3-c]pyridin...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of selectin E in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19403(2,4-diaminopyrimidine derivative, 11a | 6-[(benzyl...)
Affinity DataIC50:  0.800nM EC50:  16nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19388(2,4-diaminopyrimidine derivative, 8d | 6-[(benzylo...)
Affinity DataIC50:  1nM EC50:  85nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105151(4-(4-Vinyl-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  1nMAssay Description:Inhibition of selectin E in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105186(4-(4-Trifluoromethyl-phenoxy)-thieno[2,3-c]pyridin...)
Affinity DataIC50:  1nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19389(1-(4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimi...)
Affinity DataIC50:  1.20nM EC50:  10nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105227(4-[4-(Tetrahydro-pyran-2-yloxymethyl)-phenoxy]-thi...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181214(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((4-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19390(2,4-diaminopyrimidine derivative, 8f | 6-[(benzylo...)
Affinity DataIC50:  1.5nM EC50:  3.60nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181184(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((3-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human GHS receptor by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50158330((+/-)isobutyl 8-chloro-2-((4-(diethylamino)phenyl)...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to GHSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105201(4-(4-Imidazol-1-yl-phenoxy)-thieno[2,3-c]pyridine-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of selectin E in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105227(4-[4-(Tetrahydro-pyran-2-yloxymethyl)-phenoxy]-thi...)
Affinity DataIC50:  2nMAssay Description:Inhibition of selectin E in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105156(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory potency compared to IL-1beta induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105151(4-(4-Vinyl-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  2nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105215(4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  2nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181191(CHEMBL205711 | N-(3-chlorobenzyl)-3-(5-(4-(4-(meth...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19377(2,4-diaminopyrimidine derivative, 7c | 5-(4-{[(3,5...)
Affinity DataIC50:  2.40nM EC50:  45nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181217(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((me...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181182(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((fu...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19391(2,4-diaminopyrimidine derivative, 8g | 4-{[(4-{2,4...)
Affinity DataIC50:  2.80nM EC50:  19nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181201(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-(iso...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105155(4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of selectin E in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19392(2,4-diaminopyrimidine derivative, 8h | 6-[(benzylo...)
Affinity DataIC50:  2.90nM EC50:  97nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181180(CHEMBL377514 | N-(3,5-dimethylbenzyl)-3-(5-(4-(4-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human GHS receptor by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105215(4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of selectin E in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50153531(3-(2,6-Dichloro-phenyl)-5-(2-[1,3]dioxan-2-yl-ethy...)
Affinity DataIC50:  3nMAssay Description:Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105162(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory potency compared to TNF-alpha induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105162(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory potency compared to IL-1beta induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181229(5-[4-(4-methanesulfonyl-benzylamino)-phenyl]-6-(5-...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19409(2,4-diaminopyrimidine derivative, 13 | 6-ethyl-5-(...)
Affinity DataIC50:  3.70nM EC50:  32nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105155(4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50181225(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((be...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105195(4-(4-Pyrazol-1-yl-phenoxy)-thieno[2,3-c]pyridine-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105162(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  4nMAssay Description:Inhibition of selectin E in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105162(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory potency compared to TNF-alpha induced Selectin E expression in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105156(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory potency compared to TNF-alpha induced Selectin E in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105178(4-(4-Iodo-phenoxy)-thieno[2,3-c]pyridine-2-carboxy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105195(4-(4-Pyrazol-1-yl-phenoxy)-thieno[2,3-c]pyridine-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of selectin E in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105196(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19407(2,4-diaminopyrimidine derivative, 12a | 5-(3-chlor...)
Affinity DataIC50:  4.20nM EC50:  11nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105162(4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Affinity DataIC50:  5nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105205(4-(4-Imidazol-1-yl-phenoxy)-thieno[2,3-c]pyridine-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE-selectin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105196(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of selectin E in human endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50105156(4-{4-[2-(2-Methoxy-ethoxy)-ethoxymethyl]-phenoxy}-...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory potency compared to TNF-alpha induced Intercellular adhesion molecule-1 in human endothelial cells (ELISA assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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