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Found 241 with Last Name = 'schelkun' and Initial = 'rm'
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50080029(4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...)
Affinity DataIC50:  9nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 3A(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL
LigandPNGBDBM50079386(4-[2-(4-Benzyl-piperidin-1-yl)-ethoxy]-phenol | 4-...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibition of NMDA responses at NR1A/2B receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pgrd Michigan Laboratories

Curated by ChEMBL
LigandPNGBDBM50164279((S)-3-(aminomethyl)-5-methylhexanoic acid | (S)-3-...)
Affinity DataIC50:  73nMAssay Description:Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50032651(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)
Affinity DataIC50:  73nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50080011((2E)-3-(4-hydroxyphenyl)-N-(4-phenylbutyl)acrylami...)
Affinity DataIC50:  77nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 3A(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL
LigandPNGBDBM50088143(1-[3-(4-Benzyl-piperidin-1-yl)-propyl]-1,3-dihydro...)
Affinity DataIC50:  95nMAssay Description:In vitro inhibition of NMDA responses at NR1A/2B receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50080017((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4313((2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 3A(Rattus norvegicus (Rat))
Cocensys

Curated by ChEMBL
LigandPNGBDBM50088142(1-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-propyl}-...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibition of NMDA responses at NR1A/2B receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50080017((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Affinity DataIC50:  110nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50080016((E)-1-(4-Benzyl-piperidin-1-yl)-3-(4-hydroxy-pheny...)
Affinity DataIC50:  120nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50080018((2E)-N-[4-(4-chlorophenyl)butyl]-3-(4-hydroxypheny...)
Affinity DataIC50:  125nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50069778((2E)-3-(4-chlorophenyl)-N-[2-(4-hydroxyphenyl)ethy...)
Affinity DataIC50:  170nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pgrd Michigan Laboratories

Curated by ChEMBL
LigandPNGBDBM50171790((S)-3-(aminomethyl)-4-(furan-2-yl)butanoic acid | ...)
Affinity DataIC50:  178nMAssay Description:Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50080012((2E)-2-cyano-3-(4-hydroxyphenyl)-N-(4-phenylbutyl)...)
Affinity DataIC50:  290nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50069773((2E)-N-[2-(4-chlorophenyl)ethyl]-3-(4-hydroxypheny...)
Affinity DataIC50:  330nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030655((9S)-3-hydroxy-9-methyl-6-nitro-7,8,9,10-tetrahydr...)
Affinity DataIC50:  370nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030655((9S)-3-hydroxy-9-methyl-6-nitro-7,8,9,10-tetrahydr...)
Affinity DataIC50:  370nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pgrd Michigan Laboratories

Curated by ChEMBL
LigandPNGBDBM50171795(3-(aminomethyl)-4-(furan-2-yl)butanoic acid | CHEM...)
Affinity DataIC50:  421nMAssay Description:Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50080027(3-(4-Hydroxy-phenyl)-N-(4-phenyl-butyl)-propionami...)
Affinity DataIC50:  430nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080295(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  430nMAssay Description:Inhibition of N-type calcium channel in IMR-32 human neuroblastoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071611(6-Azepan-1-ylmethyl-2-(4,4-diphenyl-butyl)-1,2,3,4...)
Affinity DataIC50:  460nMAssay Description:Inhibition of N-type calcium channel in IMR-32 human neuroblastoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071611(6-Azepan-1-ylmethyl-2-(4,4-diphenyl-butyl)-1,2,3,4...)
Affinity DataIC50:  460nMAssay Description:Inhibition of N-type calcium channel in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080302(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  490nMAssay Description:Inhibition of N-type calcium channel in IMR-32 human neuroblastoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pgrd Michigan Laboratories

Curated by ChEMBL
LigandPNGBDBM50171794(3-(aminomethyl)-4-(furan-3-yl)butanoic acid | CHEM...)
Affinity DataIC50:  518nMAssay Description:Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4308((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbu...)
Affinity DataIC50:  560nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030670(6-Bromo-9-ethyl-1,4,7,8,9,10-hexahydro-pyrido[3,4-...)
Affinity DataIC50:  620nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030670(6-Bromo-9-ethyl-1,4,7,8,9,10-hexahydro-pyrido[3,4-...)
Affinity DataIC50:  620nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4303((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpr...)
Affinity DataIC50:  660nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM50069771((2E)-N-[2-(4-hydroxyphenyl)ethyl]-3-phenylacrylami...)
Affinity DataIC50:  680nMAssay Description:Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4303((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpr...)
Affinity DataIC50:  700nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080299(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  740nMAssay Description:Inhibition of N-type calcium channel in IMR-32 human neuroblastoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent calcium channel alpha-2 delta subunit(Sus scrofa)
Pgrd Michigan Laboratories

Curated by ChEMBL
LigandPNGBDBM50171796(3-(aminomethyl)-4-(thiophen-3-yl)butanoic acid | C...)
Affinity DataIC50:  832nMAssay Description:Displacement of [3H]gabapentin from alpha2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030663(9-(3-Methyl-butyl)-6-nitro-1,4,7,8,9,10-hexahydro-...)
Affinity DataIC50:  860nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030663(9-(3-Methyl-butyl)-6-nitro-1,4,7,8,9,10-hexahydro-...)
Affinity DataIC50:  860nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080302(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  900nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030654((9S)-3-hydroxy-9-isopropyl-6-nitro-7,8,9,10-tetrah...)
Affinity DataIC50:  930nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030654((9S)-3-hydroxy-9-isopropyl-6-nitro-7,8,9,10-tetrah...)
Affinity DataIC50:  930nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030669(9-sec-Butyl-6-nitro-1,4,7,8,9,10-hexahydro-pyrido[...)
Affinity DataIC50:  930nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030669(9-sec-Butyl-6-nitro-1,4,7,8,9,10-hexahydro-pyrido[...)
Affinity DataIC50:  930nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080296(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  970nMAssay Description:Inhibition of N-type calcium channel in IMR-32 human neuroblastoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030658(6-Bromo-1,4,7,8,9,10-hexahydro-pyrido[3,4-f]quinox...)
Affinity DataIC50:  1.00E+3nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030658(6-Bromo-1,4,7,8,9,10-hexahydro-pyrido[3,4-f]quinox...)
Affinity DataIC50:  1.00E+3nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071610(6-Azepan-1-ylmethyl-2-(6,6-diphenyl-hexyl)-1,2,3,4...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of N-type calcium channel in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oregon

Curated by ChEMBL
LigandPNGBDBM4304((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030641(1,4,7,8,9,10-Hexahydro-pyrido[2,3-f]quinoxaline-2,...)
Affinity DataIC50:  1.30E+3nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030636(9-(2-Methyl-butyl)-6-nitro-1,4,7,8,9,10-hexahydro-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50071607(6-Azepan-1-ylmethyl-2-[4,4-bis-(4-fluoro-phenyl)-b...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of N-type calcium channel in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030636(9-(2-Methyl-butyl)-6-nitro-1,4,7,8,9,10-hexahydro-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50030641(1,4,7,8,9,10-Hexahydro-pyrido[2,3-f]quinoxaline-2,...)
Affinity DataIC50:  1.30E+3nMAssay Description:Affinity for N-methyl-D-aspartate glutamate receptor 1 in rat brain synaptic membranes, using [3H]glycine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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