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Found 131 with Last Name = 'schmidt' and Initial = 'jb'
LigandPNGBDBM50106179(CHEMBL125327 | Enantiomer-4-(3-Butyl-[1,2,4]oxadia...)
Affinity DataIC50:  2nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106169(CHEMBL338973 | Enantiomer-4-(3-Butyl-[1,2,4]oxadia...)
Affinity DataIC50:  9nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106167(CHEMBL125000 | Enantiomer-4-(3-Cyclopropylmethyl-[...)
Affinity DataIC50:  18nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106167(CHEMBL125000 | Enantiomer-4-(3-Cyclopropylmethyl-[...)
Affinity DataIC50:  18nMAssay Description:Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106178(4-(3-Butyl-[1,2,4]oxadiazol-5-yl)-N-(3,3-dimethyl-...)
Affinity DataIC50:  23nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106168(CHEMBL124448 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  27nMAssay Description:Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106168(CHEMBL124448 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  27nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404297(CHEMBL269080)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0 ATP hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50061218((E)-3-(2,4-Dichloro-phenyl)-N-((R)-1-methyl-2-oxo-...)
Affinity DataIC50:  31nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404288(CHEMBL269369)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0-ATP synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404288(CHEMBL269369)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0 ATP hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106176(CHEMBL340681 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  40nMAssay Description:Bindind affinity values obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106176(CHEMBL340681 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  40nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404293(CHEMBL8024)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0 ATP hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106182(CHEMBL123085 | N-(3,3-Dimethyl-butyl)-4-(3-phenyl-...)
Affinity DataIC50:  130nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404286(CHEMBL7982)
Affinity DataIC50:  230nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0-ATP synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106166(CHEMBL122341 | N-(3,3-Dimethyl-butyl)-4-hexyloxy-b...)
Affinity DataIC50:  250nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106177(CHEMBL431682 | N-(3,3-Dimethyl-butyl)-4-indol-1-yl...)
Affinity DataIC50:  260nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404287(CHEMBL8116)
Affinity DataIC50:  280nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0-ATP synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287137(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  300nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287140(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  300nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50106184(CHEMBL121751 | N-(3,3-Dimethyl-cyclopentyl)-4-hexy...)
Affinity DataIC50:  360nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106180(CHEMBL124595 | N-(3,3-Dimethyl-cyclohexylmethyl)-4...)
Affinity DataIC50:  370nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287138(2-[(2-{[hydroxy(4-phenyl-butyl)phosphoryl]amino}-3...)
Affinity DataIC50:  400nMAssay Description:Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404289(CHEMBL8376)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0 ATP hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106181(Biphenyl-4-carboxylic acid (3,3-dimethyl-butyl)-am...)
Affinity DataIC50:  540nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106164(CHEMBL123569 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  580nMAssay Description:Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106164(CHEMBL123569 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  580nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404301(CHEMBL7871)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0-ATP synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404284(CHEMBL8064)
Affinity DataIC50:  660nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0 ATP hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404285(CHEMBL8025)
Affinity DataIC50:  710nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0 ATP hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106175(CHEMBL121750 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  710nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106175(CHEMBL121750 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  710nMAssay Description:Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287136(2-{(R)-2-Benzyl-3-[(1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  800nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287134(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  800nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287129(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  800nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  800nMAssay Description:Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287147(CHEMBL282158 | {2-Benzyl-3-[((R)-1-benzyloxycarbon...)
Affinity DataIC50:  900nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287130(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287130(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287150(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287130(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287130(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50106174(CHEMBL332297 | N-(2,2-Dimethyl-cyclohexylmethyl)-4...)
Affinity DataIC50:  1.40E+3nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404290(CHEMBL8473)
Affinity DataIC50:  2.23E+3nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0 ATP hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404300(CHEMBL7894)
Affinity DataIC50:  2.27E+3nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0 ATP hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287139(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287139(2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287141(3-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phe...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50404299(CHEMBL8199)
Affinity DataIC50:  2.41E+3nMAssay Description:Inhibitory activity against bovine mitochondrial F1F0-ATP synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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