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Found 311 with Last Name = 'schmitt' and Initial = 'ac'
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511450(CHEMBL4436749)
Affinity DataKi:  0.00200nMAssay Description:Reversible inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511450(CHEMBL4436749)
Affinity DataKi:  0.00200nMAssay Description:Reversible inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGenome polyprotein(Hepatitis C virus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50125472(4-[2-carboxy-1-methylcarboxamido-(1S)-ethylcarboxa...)
Affinity DataKi:  4nMAssay Description:Inhibitory concentration of the compound against HCV NS3 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511450(CHEMBL4436749)
Affinity DataIC50:  0.0430nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511453(CHEMBL4451394)
Affinity DataIC50: <0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511431(CHEMBL4468099)
Affinity DataIC50: <0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511430(CHEMBL4455353)
Affinity DataIC50: <0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511452(CHEMBL4570266)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511454(CHEMBL4460228)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511432(CHEMBL4435945)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511466(CHEMBL4529335)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50152144(CHEMBL3781661)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511448(CHEMBL4460446)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511428(CHEMBL4435983)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511463(CHEMBL4577002)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511457(CHEMBL4537820)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511439(CHEMBL4565830)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using dGTP as substrate measured after 30 mins by mala...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511458(CHEMBL4534555)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111938(US8618107, 104)
Affinity DataIC50:  0.870nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111953(US8618107, 212)
Affinity DataIC50:  1nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111940(US8618107, 106)
Affinity DataIC50:  1nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511441(CHEMBL4464305)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111975(US8618107, 287)
Affinity DataIC50:  1.40nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111978(US8618107, 291)
Affinity DataIC50:  1.74nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111951(US8618107, 197)
Affinity DataIC50:  2nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111956(US8618107, 268)
Affinity DataIC50:  2nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111935(US8618107, 101)
Affinity DataIC50:  2nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50125474((6S,8R)-1-Chloro-8-(3-naphthalen-1-yl-propyl)-4-ox...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against HCV NS3 protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111949(US8618107, 131)
Affinity DataIC50:  2nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111976(US8618107, 288)
Affinity DataIC50:  2.10nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111964(US8618107, 276)
Affinity DataIC50:  2.20nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111982(US8618107, 295)
Affinity DataIC50:  2.20nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50255583(CHEMBL4096813)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111962(US8618107, 274)
Affinity DataIC50:  2.34nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111966(US8618107, 278)
Affinity DataIC50:  2.60nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111954(US8618107, 265)
Affinity DataIC50:  2.80nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111972(US8618107, 284)
Affinity DataIC50:  2.80nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111983(US8618107, 296)
Affinity DataIC50:  3nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111948(US8618107, 123)
Affinity DataIC50:  3nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111994(US8618107, 308)
Affinity DataIC50:  3.30nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111965(US8618107, 277)
Affinity DataIC50:  3.40nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111974(US8618107, 286)
Affinity DataIC50:  3.40nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111987(US8618107, 300)
Affinity DataIC50:  3.40nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111973(US8618107, 285)
Affinity DataIC50:  3.60nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511464(CHEMBL4437933)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111955(US8618107, 267)
Affinity DataIC50:  3.80nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111952(US8618107, 210)
Affinity DataIC50:  3.90nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111958(US8618107, 270)
Affinity DataIC50:  4nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut

US Patent
LigandPNGBDBM111970(US8618107, 282)
Affinity DataIC50:  4nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
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