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Found 215 with Last Name = 'schoeffter' and Initial = 'p'
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Affinity DataKi:  39.8nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataIC50:  9nM EC50:  0.0200nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataIC50:  12nM EC50:  0.0600nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  22nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  24nM EC50:  0.0200nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  24nM EC50:  0.0700nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20628(2-(4-hydroxyphenyl)-1-benzothiophen-6-ol | CHEMBL4...)
Affinity DataIC50:  114nM EC50:  17nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20629(2-(3-fluoro-4-hydroxyphenyl)-1-benzothiophen-6-ol ...)
Affinity DataIC50:  115nM EC50:  32nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20636(2-(4-hydroxy-2-methylphenyl)-1-benzothiophen-6-ol ...)
Affinity DataIC50:  129nM EC50:  15nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  200nM EC50:  4.10nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20633(4-(6-hydroxy-1-benzothiophen-2-yl)benzene-1,2-diol...)
Affinity DataIC50:  249nM EC50:  525nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  260nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20636(2-(4-hydroxy-2-methylphenyl)-1-benzothiophen-6-ol ...)
Affinity DataIC50:  341nM EC50:  48nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataIC50:  480nM EC50:  0.700nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20624((1S,10R,11S,14R,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  570nM EC50:  1.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20634(2-(3-hydroxyphenyl)-1-benzothiophen-6-ol | benzthi...)
Affinity DataIC50:  740nM EC50:  245nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20629(2-(3-fluoro-4-hydroxyphenyl)-1-benzothiophen-6-ol ...)
Affinity DataIC50:  1.03E+3nM EC50:  138nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataIC50:  1.14E+3nM EC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20624((1S,10R,11S,14R,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.23E+3nM EC50:  4.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50248347(3-((2-(9H-fluoren-9-yl)ethyl)(methyl)amino)-1-(4-(...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human CYP2D6 by microplate-based direct fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20628(2-(4-hydroxyphenyl)-1-benzothiophen-6-ol | CHEMBL4...)
Affinity DataIC50:  1.41E+3nM EC50:  50nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20630(2-(4-hydroxy-3-methylphenyl)-1-benzothiophen-6-ol ...)
Affinity DataIC50:  1.83E+3nM EC50:  302nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20634(2-(3-hydroxyphenyl)-1-benzothiophen-6-ol | benzthi...)
Affinity DataIC50:  2.21E+3nM EC50:  269nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20630(2-(4-hydroxy-3-methylphenyl)-1-benzothiophen-6-ol ...)
Affinity DataIC50:  3.65E+3nM EC50:  148nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20626(2-phenyl-1-benzothiophen-6-ol | benzthiophene comp...)
Affinity DataIC50:  3.71E+3nM EC50:  209nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  3.92E+3nM EC50:  48nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20632(2-(4-hydroxy-3-propylphenyl)-1-benzothiophen-6-ol ...)
Affinity DataIC50:  3.94E+3nM EC50:  186nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20626(2-phenyl-1-benzothiophen-6-ol | benzthiophene comp...)
Affinity DataIC50:  4.31E+3nM EC50:  166nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20631(2-(3-ethyl-4-hydroxyphenyl)-1-benzothiophen-6-ol |...)
Affinity DataIC50:  4.71E+3nM EC50:  257nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20633(4-(6-hydroxy-1-benzothiophen-2-yl)benzene-1,2-diol...)
Affinity DataIC50:  4.98E+3nM EC50:  363nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50312945((4-(3,4-difluorophenyl)piperazin-1-yl)((4S,4aS,8aR...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20631(2-(3-ethyl-4-hydroxyphenyl)-1-benzothiophen-6-ol |...)
Affinity DataIC50:  7.44E+3nM EC50:  191nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20637(2-(3-fluoro-4-hydroxyphenyl)-1-benzothiophene-4,6-...)
Affinity DataIC50:  7.47E+3nM EC50: >1.00E+3nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20638(2-(4-hydroxy-3-methylphenyl)-1-benzothiophene-4,6-...)
Affinity DataIC50: >1.00E+4nM EC50: >1.00E+3nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20627(2-(4-methylphenyl)-1-benzothiophen-6-ol | benzthio...)
Affinity DataIC50: >1.00E+4nM EC50:  178nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20635(1-[2-hydroxy-5-(6-hydroxy-1-benzothiophen-2-yl)phe...)
Affinity DataIC50: >1.00E+4nM EC50: >1.00E+3nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50248555(3-((2-(9H-xanthen-9-yl)ethyl)(methyl)amino)-1-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP1A2 by microplate-based direct fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50248555(3-((2-(9H-xanthen-9-yl)ethyl)(methyl)amino)-1-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP3A4 by microplate-based direct fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50248555(3-((2-(9H-xanthen-9-yl)ethyl)(methyl)amino)-1-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2C19 by microplate-based direct fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20638(2-(4-hydroxy-3-methylphenyl)-1-benzothiophene-4,6-...)
Affinity DataIC50: >1.00E+4nM EC50: >1.00E+3nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50248347(3-((2-(9H-fluoren-9-yl)ethyl)(methyl)amino)-1-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP3A4 by microplate-based direct fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50248347(3-((2-(9H-fluoren-9-yl)ethyl)(methyl)amino)-1-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2C19 by microplate-based direct fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20635(1-[2-hydroxy-5-(6-hydroxy-1-benzothiophen-2-yl)phe...)
Affinity DataIC50: >1.00E+4nM EC50: >1.00E+3nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20627(2-(4-methylphenyl)-1-benzothiophen-6-ol | benzthio...)
Affinity DataIC50: >1.00E+4nM EC50:  174nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20632(2-(4-hydroxy-3-propylphenyl)-1-benzothiophen-6-ol ...)
Affinity DataIC50: >1.00E+4nM EC50:  162nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20637(2-(3-fluoro-4-hydroxyphenyl)-1-benzothiophene-4,6-...)
Affinity DataIC50: >1.00E+4nM EC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50248347(3-((2-(9H-fluoren-9-yl)ethyl)(methyl)amino)-1-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP1A2 by microplate-based direct fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(RAT)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50423294(CHEMBL248908)
Affinity DataKd:  1.00E+4nMAssay Description:Displacement of [125I]SRIF14 from sst2 receptor in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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