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Found 101 with Last Name = 'scholz' and Initial = 't'
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26810((5S,7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4...)
Affinity DataKi:  1.25E+3nM ΔG°:  -33.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26809((5R,7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4...)
Affinity DataKi:  1.36E+3nM ΔG°:  -33.5kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26809((5R,7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4...)
Affinity DataKi:  1.45E+3nM ΔG°:  -33.3kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26810((5S,7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4...)
Affinity DataKi:  1.92E+3nM ΔG°:  -32.6kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataKi: >2.13E+3nM ΔG°: >-32.4kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataKi:  2.80E+3nM ΔG°:  -31.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26810((5S,7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4...)
Affinity DataKi: >4.95E+3nM ΔG°: >-30.3kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataKi: >4.95E+3nM ΔG°: >-30.3kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26809((5R,7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4...)
Affinity DataKi: >4.95E+3nM ΔG°: >-30.3kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369371(CHEMBL1790750)
Affinity DataIC50:  0.123nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

LigandPNGBDBM26810((5S,7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

LigandPNGBDBM26808((7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4-yl...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

LigandPNGBDBM26809((5R,7S,8R)-7-N-hydroxy-8-N-{4-[(2-methylquinolin-4...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366557(CHEMBL1790748)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369364(CHEMBL1790760)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044312(CHEMBL302780 | Fluoro-(octane-1-sulfonyl)-methanes...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of purified human erythrocyte carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369370(CHEMBL1790745)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031179((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031169((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031167((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031170((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369371(CHEMBL1790750)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of purified human erythrocyte carbonic anhydrase IIMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044313(CHEMBL304131 | Chloro-(octane-1-sulfonyl)-methanes...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of purified human erythrocyte carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044311(CHEMBL67511 | TRIFLUOROMETHANE SULFONAMIDE | Trifl...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of purified human erythrocyte carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50407296(CHEMBL2052018 | L-731735)
Affinity DataIC50:  20nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369368(CHEMBL1790744)
Affinity DataIC50:  21nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031168((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044309((Octane-1-sulfonyl)-methanesulfonamide | CHEMBL421...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of purified human erythrocyte carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031169((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  23nMAssay Description:In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras protein by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369372(CHEMBL1790756)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369366(CHEMBL1790752)
Affinity DataIC50:  26nMAssay Description:Inhibition of bovine brain Farnesyltransferase at 1 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369375(CHEMBL1790753)
Affinity DataIC50:  27nMAssay Description:Inhibition of bovine brain Farnesyltransferase at 10 pMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031178((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369367(CHEMBL1790757)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031167((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  40nMAssay Description:In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras protein by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369363(CHEMBL1790747)
Affinity DataIC50:  42nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031179((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  46nMAssay Description:In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras protein by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031175((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  60nMAssay Description:In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras protein by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031176((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  70nMAssay Description:In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras protein by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369365(CHEMBL1790754)
Affinity DataIC50:  83nMAssay Description:Inhibition of bovine brain Farnesyltransferase at 10 pMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031162((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  86nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031170((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  97nMAssay Description:In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras protein by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-N-acetylglucosamine 1-carboxyvinyltransferase(Escherichia coli K-12 (Enterobacteria))
Heidelberg University

Curated by ChEMBL
LigandPNGBDBM50024894((1R, 2S)-1,2-epoxypropyl-phosphonic acid | (2R,3S)...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lamdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044317((2-Phenyl-ethanesulfonyl)-methanesulfonamide | CHE...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of purified human erythrocyte carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50065394((S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylami...)
Affinity DataIC50:  100nMAssay Description:Inhibition of post-translational processing of v-Ras protein in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031163((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  100nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50369369(CHEMBL1790759)
Affinity DataIC50:  110nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50031178((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  120nMAssay Description:In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras protein by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044320((3-Phenyl-propane-1-sulfonyl)-methanesulfonamide |...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibition of purified human erythrocyte carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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